Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era
<div><p>Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes patient cohort is highly heterogeneous, with individuals presenting wit...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2021
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| _version_ | 1864513516748144640 |
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| author | Ammira Al-Shabeeb Akil (15143925) |
| author2 | Esraa Yassin (11618606) Aljazi Al-Maraghi (14056975) Elbay Aliyev (14056972) Khulod Al-Malki (18324930) Khalid A. Fakhro (3158862) |
| author2_role | author author author author author |
| author_facet | Ammira Al-Shabeeb Akil (15143925) Esraa Yassin (11618606) Aljazi Al-Maraghi (14056975) Elbay Aliyev (14056972) Khulod Al-Malki (18324930) Khalid A. Fakhro (3158862) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ammira Al-Shabeeb Akil (15143925) Esraa Yassin (11618606) Aljazi Al-Maraghi (14056975) Elbay Aliyev (14056972) Khulod Al-Malki (18324930) Khalid A. Fakhro (3158862) |
| dc.date.none.fl_str_mv | 2021-04-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12967-021-02778-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Diagnosis_and_treatment_of_type_1_diabetes_at_the_dawn_of_the_personalized_medicine_era/25764333 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Type 1 diabetes Autoimmunity Personalized medicine Personalized treatment Genomic Risk Score Insulin therapy Stem cells Gene polymorphism Gene therapy Pancreatic β cells |
| dc.title.none.fl_str_mv | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes patient cohort is highly heterogeneous, with individuals presenting with disease at different stages and severities, arising from distinct etiologies, and overlaying varied genetic backgrounds. At present, the “one-size-fits-all” treatment for type 1 diabetes is exogenic insulin substitution therapy, but this approach fails to achieve optimal blood glucose control in many individuals. With advances in our understanding of early-stage diabetes development, diabetes stratification, and the role of genetics, type 1 diabetes is a promising candidate for a personalized medicine approach, which aims to apply “the right therapy at the right time, to the right patient”. In the case of type 1 diabetes, great efforts are now being focused on risk stratification for diabetes development to enable pre-clinical detection, and the application of treatments such as gene therapy, to prevent pancreatic destruction in a sub-set of patients. Alongside this, breakthroughs in stem cell therapies hold great promise for the regeneration of pancreatic tissues in some individuals. Here we review the recent initiatives in the field of personalized medicine for type 1 diabetes, including the latest discoveries in stem cell and gene therapy for the disease, and current obstacles that must be overcome before the dream of personalized medicine for all type 1 diabetes patients can be realized.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Translational Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-021-02778-6" target="_blank">https://dx.doi.org/10.1186/s12967-021-02778-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e24c360f727673854dc35f048d93f4e3 |
| identifier_str_mv | 10.1186/s12967-021-02778-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25764333 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine eraAmmira Al-Shabeeb Akil (15143925)Esraa Yassin (11618606)Aljazi Al-Maraghi (14056975)Elbay Aliyev (14056972)Khulod Al-Malki (18324930)Khalid A. Fakhro (3158862)Biomedical and clinical sciencesClinical sciencesType 1 diabetesAutoimmunityPersonalized medicinePersonalized treatmentGenomic Risk ScoreInsulin therapyStem cellsGene polymorphismGene therapyPancreatic β cells<div><p>Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes patient cohort is highly heterogeneous, with individuals presenting with disease at different stages and severities, arising from distinct etiologies, and overlaying varied genetic backgrounds. At present, the “one-size-fits-all” treatment for type 1 diabetes is exogenic insulin substitution therapy, but this approach fails to achieve optimal blood glucose control in many individuals. With advances in our understanding of early-stage diabetes development, diabetes stratification, and the role of genetics, type 1 diabetes is a promising candidate for a personalized medicine approach, which aims to apply “the right therapy at the right time, to the right patient”. In the case of type 1 diabetes, great efforts are now being focused on risk stratification for diabetes development to enable pre-clinical detection, and the application of treatments such as gene therapy, to prevent pancreatic destruction in a sub-set of patients. Alongside this, breakthroughs in stem cell therapies hold great promise for the regeneration of pancreatic tissues in some individuals. Here we review the recent initiatives in the field of personalized medicine for type 1 diabetes, including the latest discoveries in stem cell and gene therapy for the disease, and current obstacles that must be overcome before the dream of personalized medicine for all type 1 diabetes patients can be realized.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Translational Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-021-02778-6" target="_blank">https://dx.doi.org/10.1186/s12967-021-02778-6</a></p>2021-04-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12967-021-02778-6https://figshare.com/articles/journal_contribution/Diagnosis_and_treatment_of_type_1_diabetes_at_the_dawn_of_the_personalized_medicine_era/25764333CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257643332021-04-01T00:00:00Z |
| spellingShingle | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era Ammira Al-Shabeeb Akil (15143925) Biomedical and clinical sciences Clinical sciences Type 1 diabetes Autoimmunity Personalized medicine Personalized treatment Genomic Risk Score Insulin therapy Stem cells Gene polymorphism Gene therapy Pancreatic β cells |
| status_str | publishedVersion |
| title | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| title_full | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| title_fullStr | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| title_full_unstemmed | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| title_short | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| title_sort | Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era |
| topic | Biomedical and clinical sciences Clinical sciences Type 1 diabetes Autoimmunity Personalized medicine Personalized treatment Genomic Risk Score Insulin therapy Stem cells Gene polymorphism Gene therapy Pancreatic β cells |