Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota
<p dir="ltr">Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing incidence in the last decades. Although the genetic predisposition is a major risk factor, it cannot solely explain the complex etiology of T1D which is still not fully understood. In...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2020
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إضافة وسم
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| _version_ | 1864513513969418240 |
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| author | Elvira Verduci (3171957) |
| author2 | Chiara Mameli (4246564) Matilde Amatruda (18595237) Agnese Petitti (18595240) Sara Vizzuso (18595243) Farah El Assadi (16444666) Gianvincenzo Zuccotti (4732854) Shaikha Alabduljabbar (18595246) Annalisa Terranegra (3486953) |
| author2_role | author author author author author author author author |
| author_facet | Elvira Verduci (3171957) Chiara Mameli (4246564) Matilde Amatruda (18595237) Agnese Petitti (18595240) Sara Vizzuso (18595243) Farah El Assadi (16444666) Gianvincenzo Zuccotti (4732854) Shaikha Alabduljabbar (18595246) Annalisa Terranegra (3486953) |
| author_role | author |
| dc.creator.none.fl_str_mv | Elvira Verduci (3171957) Chiara Mameli (4246564) Matilde Amatruda (18595237) Agnese Petitti (18595240) Sara Vizzuso (18595243) Farah El Assadi (16444666) Gianvincenzo Zuccotti (4732854) Shaikha Alabduljabbar (18595246) Annalisa Terranegra (3486953) |
| dc.date.none.fl_str_mv | 2020-12-23T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2020.612377 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Early_Nutrition_and_Risk_of_Type_1_Diabetes_The_Role_of_Gut_Microbiota/25879579 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Nutrition and dietetics T1D early nutrition gut microbiota probiotics prebiotics post-biotics |
| dc.title.none.fl_str_mv | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing incidence in the last decades. Although the genetic predisposition is a major risk factor, it cannot solely explain the complex etiology of T1D which is still not fully understood. In this paper, we reviewed the most recent findings on the role of early nutrition and the involvement of the gut microbiota in the etiopathogenesis of T1D. The main conclusions that are withdrawn from the current literature regarding alleviating the risk of developing T1D through nutrition are the encouragement of long-term breast-feeding for at least the first 6 months of life and the avoidance of early complementary foods and gluten introduction (before 4 months of age) as well as cow milk introduction before 12 months of life. These detrimental feeding habits create a gut microbiota dysbiotic state that can contribute to the onset of T1D in infancy. Finally, we discussed the possibility to introduce probiotics, prebiotics and post-biotics in the prevention of T1D.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2020.612377" target="_blank">https://dx.doi.org/10.3389/fnut.2020.612377</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e2c8b8ab592d1607d093c5267688545f |
| identifier_str_mv | 10.3389/fnut.2020.612377 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25879579 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut MicrobiotaElvira Verduci (3171957)Chiara Mameli (4246564)Matilde Amatruda (18595237)Agnese Petitti (18595240)Sara Vizzuso (18595243)Farah El Assadi (16444666)Gianvincenzo Zuccotti (4732854)Shaikha Alabduljabbar (18595246)Annalisa Terranegra (3486953)Biomedical and clinical sciencesClinical sciencesNutrition and dieteticsT1Dearly nutritiongut microbiotaprobioticsprebioticspost-biotics<p dir="ltr">Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing incidence in the last decades. Although the genetic predisposition is a major risk factor, it cannot solely explain the complex etiology of T1D which is still not fully understood. In this paper, we reviewed the most recent findings on the role of early nutrition and the involvement of the gut microbiota in the etiopathogenesis of T1D. The main conclusions that are withdrawn from the current literature regarding alleviating the risk of developing T1D through nutrition are the encouragement of long-term breast-feeding for at least the first 6 months of life and the avoidance of early complementary foods and gluten introduction (before 4 months of age) as well as cow milk introduction before 12 months of life. These detrimental feeding habits create a gut microbiota dysbiotic state that can contribute to the onset of T1D in infancy. Finally, we discussed the possibility to introduce probiotics, prebiotics and post-biotics in the prevention of T1D.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2020.612377" target="_blank">https://dx.doi.org/10.3389/fnut.2020.612377</a></p>2020-12-23T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fnut.2020.612377https://figshare.com/articles/journal_contribution/Early_Nutrition_and_Risk_of_Type_1_Diabetes_The_Role_of_Gut_Microbiota/25879579CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258795792020-12-23T09:00:00Z |
| spellingShingle | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota Elvira Verduci (3171957) Biomedical and clinical sciences Clinical sciences Nutrition and dietetics T1D early nutrition gut microbiota probiotics prebiotics post-biotics |
| status_str | publishedVersion |
| title | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| title_full | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| title_fullStr | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| title_full_unstemmed | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| title_short | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| title_sort | Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota |
| topic | Biomedical and clinical sciences Clinical sciences Nutrition and dietetics T1D early nutrition gut microbiota probiotics prebiotics post-biotics |