Applications of polydopaminic nanomaterials in mucosal drug delivery
<p dir="ltr">Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic capacity due to their abundant surface chemist...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2023
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513542573522944 |
|---|---|
| author | Takwa Bedhiafi (14153460) |
| author2 | Sourour Idoudi (14153457) Areej Ali Alhams (17337664) Queenie Fernandes (14557388) Heba Iqbal (17337667) Renuka Basineni (17337670) Shahab Uddin (154400) Said Dermime (79420) Maysaloun Merhi (4246147) Nashiru Billa (4375261) |
| author2_role | author author author author author author author author author |
| author_facet | Takwa Bedhiafi (14153460) Sourour Idoudi (14153457) Areej Ali Alhams (17337664) Queenie Fernandes (14557388) Heba Iqbal (17337667) Renuka Basineni (17337670) Shahab Uddin (154400) Said Dermime (79420) Maysaloun Merhi (4246147) Nashiru Billa (4375261) |
| author_role | author |
| dc.creator.none.fl_str_mv | Takwa Bedhiafi (14153460) Sourour Idoudi (14153457) Areej Ali Alhams (17337664) Queenie Fernandes (14557388) Heba Iqbal (17337667) Renuka Basineni (17337670) Shahab Uddin (154400) Said Dermime (79420) Maysaloun Merhi (4246147) Nashiru Billa (4375261) |
| dc.date.none.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jconrel.2022.12.037 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Applications_of_polydopaminic_nanomaterials_in_mucosal_drug_delivery/24501028 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Polydopamine Cancer therapy Muco-adhesion Muco-penetration Mucosal drug delivery |
| dc.title.none.fl_str_mv | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic capacity due to their abundant surface chemistry. Thus, PDA is used for a myriad of applications including drug delivery, biosensing, imaging and cancer therapy. Recent reports present a new functionality of PDA as a coating nanomaterial, with major implications in mucosal drug delivery applications, particularly muco-adhesion and muco-penetration. However, this application has received minimal traction in the literature. In this review, we present the physicochemical and functional properties of PDA and highlight its key biomedical applications, especially in cancer therapy. A detailed presentation of the role of PDA as a promising coating material for nanoparticulate carriers intended for mucosal delivery forms the core aspect of the review. Finally, a reflection on key considerations and challenges in the utilizing PDA for mucosal drug delivery, along with the possibilities of translation to clinical studies is expounded.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Controlled Release<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jconrel.2022.12.037" target="_blank">https://dx.doi.org/10.1016/j.jconrel.2022.12.037</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e37971f59894167ec65637052f0ca553 |
| identifier_str_mv | 10.1016/j.jconrel.2022.12.037 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24501028 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Applications of polydopaminic nanomaterials in mucosal drug deliveryTakwa Bedhiafi (14153460)Sourour Idoudi (14153457)Areej Ali Alhams (17337664)Queenie Fernandes (14557388)Heba Iqbal (17337667)Renuka Basineni (17337670)Shahab Uddin (154400)Said Dermime (79420)Maysaloun Merhi (4246147)Nashiru Billa (4375261)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesPolydopamineCancer therapyMuco-adhesionMuco-penetrationMucosal drug delivery<p dir="ltr">Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic capacity due to their abundant surface chemistry. Thus, PDA is used for a myriad of applications including drug delivery, biosensing, imaging and cancer therapy. Recent reports present a new functionality of PDA as a coating nanomaterial, with major implications in mucosal drug delivery applications, particularly muco-adhesion and muco-penetration. However, this application has received minimal traction in the literature. In this review, we present the physicochemical and functional properties of PDA and highlight its key biomedical applications, especially in cancer therapy. A detailed presentation of the role of PDA as a promising coating material for nanoparticulate carriers intended for mucosal delivery forms the core aspect of the review. Finally, a reflection on key considerations and challenges in the utilizing PDA for mucosal drug delivery, along with the possibilities of translation to clinical studies is expounded.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Controlled Release<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jconrel.2022.12.037" target="_blank">https://dx.doi.org/10.1016/j.jconrel.2022.12.037</a></p>2023-01-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jconrel.2022.12.037https://figshare.com/articles/journal_contribution/Applications_of_polydopaminic_nanomaterials_in_mucosal_drug_delivery/24501028CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245010282023-01-01T00:00:00Z |
| spellingShingle | Applications of polydopaminic nanomaterials in mucosal drug delivery Takwa Bedhiafi (14153460) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Polydopamine Cancer therapy Muco-adhesion Muco-penetration Mucosal drug delivery |
| status_str | publishedVersion |
| title | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| title_full | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| title_fullStr | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| title_full_unstemmed | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| title_short | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| title_sort | Applications of polydopaminic nanomaterials in mucosal drug delivery |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Polydopamine Cancer therapy Muco-adhesion Muco-penetration Mucosal drug delivery |