DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases
<div><p>Background. Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here,...
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2018
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| _version_ | 1864513513368584192 |
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| author | Abdelkrim Khadir (437074) |
| author2 | Sina Kavalakatt (437073) Mohammed Dehbi (309033) Monira Alarouj (6540836) Abdullah Bennakhi (663186) Ali Tiss (437068) Naser Elkum (79418) |
| author2_role | author author author author author author |
| author_facet | Abdelkrim Khadir (437074) Sina Kavalakatt (437073) Mohammed Dehbi (309033) Monira Alarouj (6540836) Abdullah Bennakhi (663186) Ali Tiss (437068) Naser Elkum (79418) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdelkrim Khadir (437074) Sina Kavalakatt (437073) Mohammed Dehbi (309033) Monira Alarouj (6540836) Abdullah Bennakhi (663186) Ali Tiss (437068) Naser Elkum (79418) |
| dc.date.none.fl_str_mv | 2018-12-13T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2018/9529621 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/DUSP1_Is_a_Potential_Marker_of_Chronic_Inflammation_in_Arabs_with_Cardiovascular_Diseases/25921093 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Plasma levels Epidemiological studies Recurrent events Risk factors Multivariate logistic regression analysis Statin treatment Diabetes |
| dc.title.none.fl_str_mv | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Background. Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by assessing plasma dual-specificity phosphatase 1 (DUSP1) levels and comparing them to high-sensitivity CRP (hsCRP) and oxidized low-density lipoprotein (oxLDL) levels and their associations to conventional CVD risk factors in confirmed CVD patients.Methods. Human adults with reported CVD (n=207) and controls (n=70) living in Kuwait were used in this study. Anthropometric and classical biochemical parameters were determined. Plasma levels of DUSP1, oxLDL, and hsCRP were measured using human enzyme-linked immunosorbent assay kits.Results. DUSP1 and hsCRP plasma levels and their least square means were higher in CVD cases, while oxLDL plasma levels were lower (p<0.05). Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. In our study, DUSP1 levels were found to be associated with CVD despite statin treatment and diabetes status (p<0.05), whereas hsCRP mainly correlated with obesity markers.Conclusions. Circulating DUSP1 might be a predictor of chronic subclinical inflammation and residual risk in CVD patients, whereas our data suggest that the association between hsCRP and CVD is largely accounted for adiposity risk factors.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Disease Markers<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2018/9529621" target="_blank">https://dx.doi.org/10.1155/2018/9529621</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e42be05f1d0b60ab910b836e2457ab12 |
| identifier_str_mv | 10.1155/2018/9529621 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25921093 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular DiseasesAbdelkrim Khadir (437074)Sina Kavalakatt (437073)Mohammed Dehbi (309033)Monira Alarouj (6540836)Abdullah Bennakhi (663186)Ali Tiss (437068)Naser Elkum (79418)Biomedical and clinical sciencesCardiovascular medicine and haematologyPlasma levelsEpidemiological studiesRecurrent eventsRisk factorsMultivariate logistic regression analysisStatin treatmentDiabetes<div><p>Background. Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by assessing plasma dual-specificity phosphatase 1 (DUSP1) levels and comparing them to high-sensitivity CRP (hsCRP) and oxidized low-density lipoprotein (oxLDL) levels and their associations to conventional CVD risk factors in confirmed CVD patients.Methods. Human adults with reported CVD (n=207) and controls (n=70) living in Kuwait were used in this study. Anthropometric and classical biochemical parameters were determined. Plasma levels of DUSP1, oxLDL, and hsCRP were measured using human enzyme-linked immunosorbent assay kits.Results. DUSP1 and hsCRP plasma levels and their least square means were higher in CVD cases, while oxLDL plasma levels were lower (p<0.05). Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. In our study, DUSP1 levels were found to be associated with CVD despite statin treatment and diabetes status (p<0.05), whereas hsCRP mainly correlated with obesity markers.Conclusions. Circulating DUSP1 might be a predictor of chronic subclinical inflammation and residual risk in CVD patients, whereas our data suggest that the association between hsCRP and CVD is largely accounted for adiposity risk factors.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Disease Markers<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2018/9529621" target="_blank">https://dx.doi.org/10.1155/2018/9529621</a></p>2018-12-13T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2018/9529621https://figshare.com/articles/journal_contribution/DUSP1_Is_a_Potential_Marker_of_Chronic_Inflammation_in_Arabs_with_Cardiovascular_Diseases/25921093CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259210932018-12-13T03:00:00Z |
| spellingShingle | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases Abdelkrim Khadir (437074) Biomedical and clinical sciences Cardiovascular medicine and haematology Plasma levels Epidemiological studies Recurrent events Risk factors Multivariate logistic regression analysis Statin treatment Diabetes |
| status_str | publishedVersion |
| title | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| title_full | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| title_fullStr | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| title_full_unstemmed | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| title_short | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| title_sort | DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Plasma levels Epidemiological studies Recurrent events Risk factors Multivariate logistic regression analysis Statin treatment Diabetes |