Claustrum sparing sign in seronegative limbic encephalitis
<h3>Background</h3> <p>Limbic encephalitis (LE) is a rare variant of autoimmune encephalitis. It often manifests with subacute neuropsychiatric symptoms of agitation, delusions, variable seizure semiology, and short-term memory loss. Seronegative limbic encephalitis can pose a diag...
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| مؤلفون آخرون: | , , , , |
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2023
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| _version_ | 1864513564629270528 |
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| author | Abeer Sabry Safan (14777968) |
| author2 | Mohammad Al-Termanini (15901273) Mohamed Abdelhady (15901276) Yasir Osman (9401848) Abdel-Nasser Y. Awad Elzouki (15901280) Ahmed Lutfe Abdussalam (15901286) |
| author2_role | author author author author author |
| author_facet | Abeer Sabry Safan (14777968) Mohammad Al-Termanini (15901273) Mohamed Abdelhady (15901276) Yasir Osman (9401848) Abdel-Nasser Y. Awad Elzouki (15901280) Ahmed Lutfe Abdussalam (15901286) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abeer Sabry Safan (14777968) Mohammad Al-Termanini (15901273) Mohamed Abdelhady (15901276) Yasir Osman (9401848) Abdel-Nasser Y. Awad Elzouki (15901280) Ahmed Lutfe Abdussalam (15901286) |
| dc.date.none.fl_str_mv | 2023-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ensci.2023.100465 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Claustrum_sparing_sign_in_seronegative_limbic_encephalitis/23176250 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Limbic encephalitis Seizure Claustrum sparing sign Seronegative |
| dc.title.none.fl_str_mv | Claustrum sparing sign in seronegative limbic encephalitis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3> <p>Limbic encephalitis (LE) is a rare variant of autoimmune encephalitis. It often manifests with subacute neuropsychiatric symptoms of agitation, delusions, variable seizure semiology, and short-term memory loss. Seronegative limbic encephalitis can pose a diagnostic conundrum owing to its inadequately understood pathophysiology.</p> <h3>Case presentation</h3> <p>We report a rare case of a young male with subacute neuropsychiatric manifestations of delusions, agitations and seizures. He was diagnosed with seronegative limbic encephalitis (SNLE). Brain MRI demonstrated bilateral Claustrum sparing sign. An EEG showed continuous left-sided epileptiform discharges in periodic to predominantly left middle temporal. Patient condition gradually improved with pulsed methylprednisolone, intravenous immunoglobulins and anti-seizure medications.</p> <h3>Conclusion</h3> <p>Claustrum remains one of the least understood neuroanatomical structures. Claustrum sign has been reported in febrile infection-related epilepsy syndrome (FIRES), LE, and autoimmune refractory epilepsy. To the best of our knowledge, we report the first case in literature with Claustrum sparing sign in seronegative Limbic Encephalitis. Further experimental models and researches are warranted to better understand the unique function of the claustrum and unravel possible other attributable auto-antibodies, which could alter treatment and prognosis.</p> <h2>Other Information</h2> <p>Published in: eNeurologicalSci<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://doi.org/10.1016/j.ensci.2023.100465" target="_blank">https://doi.org/10.1016/j.ensci.2023.100465</a> </p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e45e653f9fb55eb6f52ee462e2628596 |
| identifier_str_mv | 10.1016/j.ensci.2023.100465 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23176250 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Claustrum sparing sign in seronegative limbic encephalitisAbeer Sabry Safan (14777968)Mohammad Al-Termanini (15901273)Mohamed Abdelhady (15901276)Yasir Osman (9401848)Abdel-Nasser Y. Awad Elzouki (15901280)Ahmed Lutfe Abdussalam (15901286)Biomedical and clinical sciencesNeurosciencesLimbic encephalitisSeizureClaustrum sparing signSeronegative<h3>Background</h3> <p>Limbic encephalitis (LE) is a rare variant of autoimmune encephalitis. It often manifests with subacute neuropsychiatric symptoms of agitation, delusions, variable seizure semiology, and short-term memory loss. Seronegative limbic encephalitis can pose a diagnostic conundrum owing to its inadequately understood pathophysiology.</p> <h3>Case presentation</h3> <p>We report a rare case of a young male with subacute neuropsychiatric manifestations of delusions, agitations and seizures. He was diagnosed with seronegative limbic encephalitis (SNLE). Brain MRI demonstrated bilateral Claustrum sparing sign. An EEG showed continuous left-sided epileptiform discharges in periodic to predominantly left middle temporal. Patient condition gradually improved with pulsed methylprednisolone, intravenous immunoglobulins and anti-seizure medications.</p> <h3>Conclusion</h3> <p>Claustrum remains one of the least understood neuroanatomical structures. Claustrum sign has been reported in febrile infection-related epilepsy syndrome (FIRES), LE, and autoimmune refractory epilepsy. To the best of our knowledge, we report the first case in literature with Claustrum sparing sign in seronegative Limbic Encephalitis. Further experimental models and researches are warranted to better understand the unique function of the claustrum and unravel possible other attributable auto-antibodies, which could alter treatment and prognosis.</p> <h2>Other Information</h2> <p>Published in: eNeurologicalSci<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://doi.org/10.1016/j.ensci.2023.100465" target="_blank">https://doi.org/10.1016/j.ensci.2023.100465</a> </p>2023-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ensci.2023.100465https://figshare.com/articles/journal_contribution/Claustrum_sparing_sign_in_seronegative_limbic_encephalitis/23176250CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/231762502023-06-01T00:00:00Z |
| spellingShingle | Claustrum sparing sign in seronegative limbic encephalitis Abeer Sabry Safan (14777968) Biomedical and clinical sciences Neurosciences Limbic encephalitis Seizure Claustrum sparing sign Seronegative |
| status_str | publishedVersion |
| title | Claustrum sparing sign in seronegative limbic encephalitis |
| title_full | Claustrum sparing sign in seronegative limbic encephalitis |
| title_fullStr | Claustrum sparing sign in seronegative limbic encephalitis |
| title_full_unstemmed | Claustrum sparing sign in seronegative limbic encephalitis |
| title_short | Claustrum sparing sign in seronegative limbic encephalitis |
| title_sort | Claustrum sparing sign in seronegative limbic encephalitis |
| topic | Biomedical and clinical sciences Neurosciences Limbic encephalitis Seizure Claustrum sparing sign Seronegative |