The role of PAK4 in the immune system and its potential implication in cancer immunotherapy
<p dir="ltr">The p21 activated kinases (PAKs) are known to play a role in the regulation of cell morphology and functions. Among the various members of PAKs family, only the PAK4 protein has been shown to be overexpressed in cancer cells and its upregulation was associated with tumor...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
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| _version_ | 1864513547000610816 |
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| author | Azza Naїja (17280610) |
| author2 | Maysaloun Merhi (4246147) Varghese Inchakalody (15263530) Queenie Fernandes (14557388) Sarra Mestiri (14557379) Kirti S. Prabhu (4246144) Shahab Uddin (154400) Said Dermime (79420) |
| author2_role | author author author author author author author |
| author_facet | Azza Naїja (17280610) Maysaloun Merhi (4246147) Varghese Inchakalody (15263530) Queenie Fernandes (14557388) Sarra Mestiri (14557379) Kirti S. Prabhu (4246144) Shahab Uddin (154400) Said Dermime (79420) |
| author_role | author |
| dc.creator.none.fl_str_mv | Azza Naїja (17280610) Maysaloun Merhi (4246147) Varghese Inchakalody (15263530) Queenie Fernandes (14557388) Sarra Mestiri (14557379) Kirti S. Prabhu (4246144) Shahab Uddin (154400) Said Dermime (79420) |
| dc.date.none.fl_str_mv | 2021-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cellimm.2021.104408 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_role_of_PAK4_in_the_immune_system_and_its_potential_implication_in_cancer_immunotherapy/24433186 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis PAK4 Tumorigenesis PD-1 Immunotherapy |
| dc.title.none.fl_str_mv | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The p21 activated kinases (PAKs) are known to play a role in the regulation of cell morphology and functions. Among the various members of PAKs family, only the PAK4 protein has been shown to be overexpressed in cancer cells and its upregulation was associated with tumor development. Indeed, several studies have shown that PAK4 overexpression is implicated in carcinogenesis by different mechanisms including promotion of cell proliferation, invasion and migration, protection of cells from apoptosis, stimulation of the tumor-specific anchorage-independent cell growth and regulation of the cytoskeletal organisation and adhesion. Moreover, high PAK4 protein levels have been observed in several solid tumors and have been shown able to enhance cancer cell resistance to many treatments especially chemotherapy. Interestingly, it has been recently demonstrated that PAK4 downregulation can inhibit the PD-1/PD-L1 immune regulatory pathway. Taken together, these findings not only implicate PAK4 in oncogenic transformation and in prediction of tumor response to treatment but also suggest its role as an attractive target for immunotherapy. In the current review we will summarize the different mechanisms of PAK4 implication in tumor development, describe its role as a regulator of the immune response and as a potential novel target for cancer immunotherapy.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular Immunology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cellimm.2021.104408" target="_blank">https://dx.doi.org/10.1016/j.cellimm.2021.104408</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e471db7addf3bf0a6115b73a838be2c3 |
| identifier_str_mv | 10.1016/j.cellimm.2021.104408 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24433186 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The role of PAK4 in the immune system and its potential implication in cancer immunotherapyAzza Naїja (17280610)Maysaloun Merhi (4246147)Varghese Inchakalody (15263530)Queenie Fernandes (14557388)Sarra Mestiri (14557379)Kirti S. Prabhu (4246144)Shahab Uddin (154400)Said Dermime (79420)Biomedical and clinical sciencesImmunologyOncology and carcinogenesisPAK4TumorigenesisPD-1Immunotherapy<p dir="ltr">The p21 activated kinases (PAKs) are known to play a role in the regulation of cell morphology and functions. Among the various members of PAKs family, only the PAK4 protein has been shown to be overexpressed in cancer cells and its upregulation was associated with tumor development. Indeed, several studies have shown that PAK4 overexpression is implicated in carcinogenesis by different mechanisms including promotion of cell proliferation, invasion and migration, protection of cells from apoptosis, stimulation of the tumor-specific anchorage-independent cell growth and regulation of the cytoskeletal organisation and adhesion. Moreover, high PAK4 protein levels have been observed in several solid tumors and have been shown able to enhance cancer cell resistance to many treatments especially chemotherapy. Interestingly, it has been recently demonstrated that PAK4 downregulation can inhibit the PD-1/PD-L1 immune regulatory pathway. Taken together, these findings not only implicate PAK4 in oncogenic transformation and in prediction of tumor response to treatment but also suggest its role as an attractive target for immunotherapy. In the current review we will summarize the different mechanisms of PAK4 implication in tumor development, describe its role as a regulator of the immune response and as a potential novel target for cancer immunotherapy.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular Immunology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cellimm.2021.104408" target="_blank">https://dx.doi.org/10.1016/j.cellimm.2021.104408</a></p>2021-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cellimm.2021.104408https://figshare.com/articles/journal_contribution/The_role_of_PAK4_in_the_immune_system_and_its_potential_implication_in_cancer_immunotherapy/24433186CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244331862021-09-01T00:00:00Z |
| spellingShingle | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy Azza Naїja (17280610) Biomedical and clinical sciences Immunology Oncology and carcinogenesis PAK4 Tumorigenesis PD-1 Immunotherapy |
| status_str | publishedVersion |
| title | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| title_full | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| title_fullStr | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| title_full_unstemmed | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| title_short | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| title_sort | The role of PAK4 in the immune system and its potential implication in cancer immunotherapy |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis PAK4 Tumorigenesis PD-1 Immunotherapy |