Lorcaserin vs. Phentermine among non-surgical and surgical obese patients: Anthropometric, glycemic, lipid, safety and cost outcomes
<h3>Background</h3><p dir="ltr">To evaluate effectiveness, safety, and costs of Lorcaserin <i>vs.</i> phentermine among obese non–surgical and surgical patients (post bariatric surgery).</p><h3>Methods</h3><p dir="ltr">This re...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2019
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إضافة وسم
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| الملخص: | <h3>Background</h3><p dir="ltr">To evaluate effectiveness, safety, and costs of Lorcaserin <i>vs.</i> phentermine among obese non–surgical and surgical patients (post bariatric surgery).</p><h3>Methods</h3><p dir="ltr">This retrospective study retrieved charts of all patients (January 2013–June 2016) who received Lorcaserin or phentermine for 3 months. The study assessed anthropometric, glycemic, and lipid changes, as well as side effects and cost of medications among overweight and obese non-surgical (n = 83) and surgical patients (n = 46). These two patient groups were compared using Chi-square (χ2) and unpaired‘t’ test for qualitative and quantitative variables respectively.</p><h3>Results</h3><p dir="ltr">At 3 months, among the non-surgical group, Phentermine patients had greater percentage of total weight loss (TWL%) (7.65 ± 8.26 <i>vs.</i> 2.99 ± 3.72%, P = 0.003), and greater BMI reduction (−3.16 ± 3.63 <i>vs.</i> −1.15 ± 1.53 kg/m <sup>2</sup> , P = 0.003) than Lorcaserin. Within the surgical group, Lorcaserin patients had significantly smaller TWL% (1.86 ± 5.06 <i>vs.</i> 7.62 ± 9.80%, P = 0.012), and smaller BMI reduction (−0.74 ± 1.80 <i>vs.</i> −3.06 ± 4.08 kg/m <sup>2</sup> , P = 0.012) than Phentermine. Lorcaserin exhibited significant total cholesterol and LDL improvements only among surgical patients with significant weight reduction (≥5% TW). Both medications were not associated with glycemic improvements among non-surgical and surgical groups. Phentermine had slightly more side effects but was less expensive.</p><h3>Conclusions</h3><p dir="ltr">Among both patient groups, phentermine was more effective in achieving weight loss. Lorcaserin showed dyslipidemia improvements only among surgical patients who achieved significant weight reduction. Anti-obesity medications as part of weight management programs can result in weight loss among non-surgical and surgical patients, or halt weight regain among surgical patients. This is the first study to evaluate the effectiveness and safety of two anti-obesity medications (lorcaserin vs. phentermine) among two distinct obese patient groups, non-surgical and surgical patients.</p><p><br></p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Medicine and Surgery<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.amsu.2019.07.024" target="_blank">https://dx.doi.org/10.1016/j.amsu.2019.07.024</a></p> |
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