Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies
<div><p>The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major ani...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2021
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| الموضوعات: | |
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| _version_ | 1864513516130533376 |
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| author | Maha Alser (6695090) |
| author2 | Samar Shurbaji (9938696) Huseyin C. Yalcin (6695099) |
| author2_role | author author |
| author_facet | Maha Alser (6695090) Samar Shurbaji (9938696) Huseyin C. Yalcin (6695099) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maha Alser (6695090) Samar Shurbaji (9938696) Huseyin C. Yalcin (6695099) |
| dc.date.none.fl_str_mv | 2021-03-26T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/jcdd8040032 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Mechanosensitive_Pathways_in_Heart_Development_Findings_from_Chick_Embryo_Studies/25780992 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology chick embryo hemodynamics mechanobiology mechanosensitive pathways surgical interferences left atrial ligation outflow tract banding vitelline vein ligation chemical treatment gene expression |
| dc.title.none.fl_str_mv | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. Such manipulations alter expressions of mechanosensitive genes which may anticipate induction of morphological changes in the developing heart. This paper aims to present different approaches for generating clinically relevant disturbed hemodynamics conditions using this embryonic chick model and to summarize identified mechanosensitive genes using the model, providing insights into embryonic origins of congenital heart defects.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Cardiovascular Development and Disease<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/jcdd8040032" target="_blank">https://dx.doi.org/10.3390/jcdd8040032</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e4eb22c95cdf04b512d3d762810e34a0 |
| identifier_str_mv | 10.3390/jcdd8040032 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25780992 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo StudiesMaha Alser (6695090)Samar Shurbaji (9938696)Huseyin C. Yalcin (6695099)Biomedical and clinical sciencesCardiovascular medicine and haematologychick embryohemodynamicsmechanobiologymechanosensitive pathwayssurgical interferencesleft atrial ligationoutflow tract bandingvitelline vein ligationchemical treatmentgene expression<div><p>The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. Such manipulations alter expressions of mechanosensitive genes which may anticipate induction of morphological changes in the developing heart. This paper aims to present different approaches for generating clinically relevant disturbed hemodynamics conditions using this embryonic chick model and to summarize identified mechanosensitive genes using the model, providing insights into embryonic origins of congenital heart defects.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Cardiovascular Development and Disease<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/jcdd8040032" target="_blank">https://dx.doi.org/10.3390/jcdd8040032</a></p>2021-03-26T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/jcdd8040032https://figshare.com/articles/journal_contribution/Mechanosensitive_Pathways_in_Heart_Development_Findings_from_Chick_Embryo_Studies/25780992CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257809922021-03-26T03:00:00Z |
| spellingShingle | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies Maha Alser (6695090) Biomedical and clinical sciences Cardiovascular medicine and haematology chick embryo hemodynamics mechanobiology mechanosensitive pathways surgical interferences left atrial ligation outflow tract banding vitelline vein ligation chemical treatment gene expression |
| status_str | publishedVersion |
| title | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| title_full | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| title_fullStr | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| title_full_unstemmed | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| title_short | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| title_sort | Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology chick embryo hemodynamics mechanobiology mechanosensitive pathways surgical interferences left atrial ligation outflow tract banding vitelline vein ligation chemical treatment gene expression |