Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo
<p dir="ltr">Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart‘s pumping power, ventricles are particularly affected by developmental abnormalities, such as...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2022
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| _version_ | 1864513548760121344 |
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| author | Maha Alser (6695090) |
| author2 | Huseyin Enes Salman (18131794) Azza Naïja (19137067) Thomas Daniel Seers (21324155) Talha Khan (8862323) Huseyin Cagatay Yalcin (14149953) |
| author2_role | author author author author author |
| author_facet | Maha Alser (6695090) Huseyin Enes Salman (18131794) Azza Naïja (19137067) Thomas Daniel Seers (21324155) Talha Khan (8862323) Huseyin Cagatay Yalcin (14149953) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maha Alser (6695090) Huseyin Enes Salman (18131794) Azza Naïja (19137067) Thomas Daniel Seers (21324155) Talha Khan (8862323) Huseyin Cagatay Yalcin (14149953) |
| dc.date.none.fl_str_mv | 2022-04-14T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fphys.2022.849603 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Blood_Flow_Disturbance_and_Morphological_Alterations_Following_the_Right_Atrial_Ligation_in_the_Chick_Embryo/29022731 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Engineering Biomedical engineering congenital heart defects ventricle chick embryo right atrial ligation ultrasound micro-CT hemodynamics computational fluid dynamics |
| dc.title.none.fl_str_mv | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart‘s pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Physiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphys.2022.849603" target="_blank">https://dx.doi.org/10.3389/fphys.2022.849603</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e4fc602adb5277b46efbd393e330c05e |
| identifier_str_mv | 10.3389/fphys.2022.849603 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29022731 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick EmbryoMaha Alser (6695090)Huseyin Enes Salman (18131794)Azza Naïja (19137067)Thomas Daniel Seers (21324155)Talha Khan (8862323)Huseyin Cagatay Yalcin (14149953)Biomedical and clinical sciencesCardiovascular medicine and haematologyEngineeringBiomedical engineeringcongenital heart defectsventriclechick embryoright atrial ligationultrasoundmicro-CThemodynamicscomputational fluid dynamics<p dir="ltr">Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart‘s pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Physiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphys.2022.849603" target="_blank">https://dx.doi.org/10.3389/fphys.2022.849603</a></p>2022-04-14T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fphys.2022.849603https://figshare.com/articles/journal_contribution/Blood_Flow_Disturbance_and_Morphological_Alterations_Following_the_Right_Atrial_Ligation_in_the_Chick_Embryo/29022731CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290227312022-04-14T09:00:00Z |
| spellingShingle | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo Maha Alser (6695090) Biomedical and clinical sciences Cardiovascular medicine and haematology Engineering Biomedical engineering congenital heart defects ventricle chick embryo right atrial ligation ultrasound micro-CT hemodynamics computational fluid dynamics |
| status_str | publishedVersion |
| title | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| title_full | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| title_fullStr | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| title_full_unstemmed | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| title_short | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| title_sort | Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Engineering Biomedical engineering congenital heart defects ventricle chick embryo right atrial ligation ultrasound micro-CT hemodynamics computational fluid dynamics |