The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome
<p dir="ltr">The SARS-CoV-2 coronavirus enters target cells via the angiotensin-converting enzyme 2 (ACE2) receptor; however, ACE2 expression does not match SARS-CoV-2 tissue load, suggesting additional co-factors are required for viral entry [1]. Neuropilin-1 (NRP1) is such a co-fac...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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| الموضوعات: | |
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| _version_ | 1864513511937277952 |
|---|---|
| author | Abu Saleh Md Moin (6189512) |
| author2 | Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| author2_role | author author author |
| author_facet | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| dc.date.none.fl_str_mv | 2021-03-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.metop.2021.100079 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_relationship_of_soluble_neuropilin-1_to_severe_COVID-19_risk_factors_in_polycystic_ovary_syndrome/26114350 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Reproductive medicine Neuropilin-1 Polycystic ovary syndrome COVID-19 SARS-CoV-2 |
| dc.title.none.fl_str_mv | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The SARS-CoV-2 coronavirus enters target cells via the angiotensin-converting enzyme 2 (ACE2) receptor; however, ACE2 expression does not match SARS-CoV-2 tissue load, suggesting additional co-factors are required for viral entry [1]. Neuropilin-1 (NRP1) is such a co-factor that, when expressed alone shows minimal viral infectivity, but when co-expressed with ACE2 markedly increases viral infectivity [1]. NRP1 is a transmembrane glycoprotein, which is expressed in endothelial cells, and serves as a receptor for vascular endothelial growth factor (VEGF) [2], and both NRP1 and VEGF expression are increased in COVID-19 patients [3,4]. SARS-CoV-2 uses the viral spike protein for cell entry, cleaving the protein that then attaches to NRP1 [5]. Therefore, tissues enriched for NRP1 have increased infectivity risk [1] and subjects expressing increased NRP1 may have increased risk.</p><h2>Other Information</h2><p dir="ltr">Published in: Metabolism Open<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.metop.2021.100079" target="_blank">https://dx.doi.org/10.1016/j.metop.2021.100079</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e505988b051cf42856bf97b4b2c3030e |
| identifier_str_mv | 10.1016/j.metop.2021.100079 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114350 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndromeAbu Saleh Md Moin (6189512)Thozhukat Sathyapalan (704787)Stephen L. Atkin (6684368)Alexandra E. Butler (6189536)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsReproductive medicineNeuropilin-1Polycystic ovary syndromeCOVID-19SARS-CoV-2<p dir="ltr">The SARS-CoV-2 coronavirus enters target cells via the angiotensin-converting enzyme 2 (ACE2) receptor; however, ACE2 expression does not match SARS-CoV-2 tissue load, suggesting additional co-factors are required for viral entry [1]. Neuropilin-1 (NRP1) is such a co-factor that, when expressed alone shows minimal viral infectivity, but when co-expressed with ACE2 markedly increases viral infectivity [1]. NRP1 is a transmembrane glycoprotein, which is expressed in endothelial cells, and serves as a receptor for vascular endothelial growth factor (VEGF) [2], and both NRP1 and VEGF expression are increased in COVID-19 patients [3,4]. SARS-CoV-2 uses the viral spike protein for cell entry, cleaving the protein that then attaches to NRP1 [5]. Therefore, tissues enriched for NRP1 have increased infectivity risk [1] and subjects expressing increased NRP1 may have increased risk.</p><h2>Other Information</h2><p dir="ltr">Published in: Metabolism Open<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.metop.2021.100079" target="_blank">https://dx.doi.org/10.1016/j.metop.2021.100079</a></p>2021-03-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.metop.2021.100079https://figshare.com/articles/journal_contribution/The_relationship_of_soluble_neuropilin-1_to_severe_COVID-19_risk_factors_in_polycystic_ovary_syndrome/26114350CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261143502021-03-01T00:00:00Z |
| spellingShingle | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome Abu Saleh Md Moin (6189512) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Reproductive medicine Neuropilin-1 Polycystic ovary syndrome COVID-19 SARS-CoV-2 |
| status_str | publishedVersion |
| title | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| title_full | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| title_fullStr | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| title_full_unstemmed | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| title_short | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| title_sort | The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Reproductive medicine Neuropilin-1 Polycystic ovary syndrome COVID-19 SARS-CoV-2 |