BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells

<h3>Introduction</h3><p dir="ltr">Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma. However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic agents against...

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Bibliographic Details
Main Author: Ali Alhoshani (3720718) (author)
Other Authors: Fahad O Alatawi (16555622) (author), Fawaz E Al-Anazi (16555625) (author), Ibraheem M. Attafi (14151735) (author), Asad Zeidan (8879705) (author), Abdelali Agouni (181926) (author), Heba M El Gamal (16555631) (author), Licia S Shamoon (16555641) (author), Sarah Khalaf (16555642) (author), Hesham M Korashy (16555645) (author)
Published: 2020
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
venetoclax
MDA-MB-231 cells
breast cancer
apoptosis
BCL-2
cell cycle
autophagy
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