Metabolomics in the Diagnosis and Prognosis of COVID-19
<p dir="ltr">Coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented global effort in developing rapid and inexpensive diagnostic and prognostic tools. Since the genome of SARS-CoV-2 was uncovered, detection of viral RNA by RT-qPCR has played the most significant role...
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2021
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| author | Mohammad Rubayet Hasan (8602080) |
| author2 | Mohammed Suleiman (9626402) Andrés Pérez-López (16554387) |
| author2_role | author author |
| author_facet | Mohammad Rubayet Hasan (8602080) Mohammed Suleiman (9626402) Andrés Pérez-López (16554387) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohammad Rubayet Hasan (8602080) Mohammed Suleiman (9626402) Andrés Pérez-López (16554387) |
| dc.date.none.fl_str_mv | 2021-06-23T12:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fgene.2021.721556 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolomics_in_the_Diagnosis_and_Prognosis_of_COVID-19/28930799 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics COVID-19 SARS-CoV-2 metabolomics diagnosis prognosis volatile organic compounds mass-spectrometry nuclear magnetic resonance |
| dc.title.none.fl_str_mv | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented global effort in developing rapid and inexpensive diagnostic and prognostic tools. Since the genome of SARS-CoV-2 was uncovered, detection of viral RNA by RT-qPCR has played the most significant role in preventing the spread of the virus through early detection and tracing of suspected COVID-19 cases and through screening of at-risk population. However, a large number of alternative test methods based on SARS-CoV-2 RNA or proteins or host factors associated with SARS-CoV-2 infection have been developed and evaluated. The application of metabolomics in infectious disease diagnostics is an evolving area of science that was boosted by the urgency of COVID-19 pandemic. Metabolomics approaches that rely on the analysis of volatile organic compounds exhaled by COVID-19 patients hold promise for applications in a large-scale screening of population in point-of-care (POC) setting. On the other hand, successful application of mass-spectrometry to detect specific spectral signatures associated with COVID-19 in nasopharyngeal swab specimens may significantly save the cost and turnaround time of COVID-19 testing in the diagnostic microbiology and virology laboratories. Active research is also ongoing on the discovery of potential metabolomics-based prognostic markers for the disease that can be applied to serum or plasma specimens. Several metabolic pathways related to amino acid, lipid and energy metabolism were found to be affected by severe disease with COVID-19. In particular, tryptophan metabolism via the kynurenine pathway were persistently dysregulated in several independent studies, suggesting the roles of several metabolites of this pathway such as tryptophan, kynurenine and 3-hydroxykynurenine as potential prognostic markers of the disease. However, standardization of the test methods and large-scale clinical validation are necessary before these tests can be applied in a clinical setting. With rapidly expanding data on the metabolic profiles of COVID-19 patients with varying degrees of severity, it is likely that metabolomics will play an important role in near future in predicting the outcome of the disease with a greater degree of certainty.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2021.721556" target="_blank">https://dx.doi.org/10.3389/fgene.2021.721556</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e5ed787b7c5e1742ce8a32d10818e327 |
| identifier_str_mv | 10.3389/fgene.2021.721556 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28930799 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolomics in the Diagnosis and Prognosis of COVID-19Mohammad Rubayet Hasan (8602080)Mohammed Suleiman (9626402)Andrés Pérez-López (16554387)Biological sciencesMicrobiologyBiomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsCOVID-19SARS-CoV-2metabolomicsdiagnosisprognosisvolatile organic compoundsmass-spectrometrynuclear magnetic resonance<p dir="ltr">Coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented global effort in developing rapid and inexpensive diagnostic and prognostic tools. Since the genome of SARS-CoV-2 was uncovered, detection of viral RNA by RT-qPCR has played the most significant role in preventing the spread of the virus through early detection and tracing of suspected COVID-19 cases and through screening of at-risk population. However, a large number of alternative test methods based on SARS-CoV-2 RNA or proteins or host factors associated with SARS-CoV-2 infection have been developed and evaluated. The application of metabolomics in infectious disease diagnostics is an evolving area of science that was boosted by the urgency of COVID-19 pandemic. Metabolomics approaches that rely on the analysis of volatile organic compounds exhaled by COVID-19 patients hold promise for applications in a large-scale screening of population in point-of-care (POC) setting. On the other hand, successful application of mass-spectrometry to detect specific spectral signatures associated with COVID-19 in nasopharyngeal swab specimens may significantly save the cost and turnaround time of COVID-19 testing in the diagnostic microbiology and virology laboratories. Active research is also ongoing on the discovery of potential metabolomics-based prognostic markers for the disease that can be applied to serum or plasma specimens. Several metabolic pathways related to amino acid, lipid and energy metabolism were found to be affected by severe disease with COVID-19. In particular, tryptophan metabolism via the kynurenine pathway were persistently dysregulated in several independent studies, suggesting the roles of several metabolites of this pathway such as tryptophan, kynurenine and 3-hydroxykynurenine as potential prognostic markers of the disease. However, standardization of the test methods and large-scale clinical validation are necessary before these tests can be applied in a clinical setting. With rapidly expanding data on the metabolic profiles of COVID-19 patients with varying degrees of severity, it is likely that metabolomics will play an important role in near future in predicting the outcome of the disease with a greater degree of certainty.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2021.721556" target="_blank">https://dx.doi.org/10.3389/fgene.2021.721556</a></p>2021-06-23T12:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fgene.2021.721556https://figshare.com/articles/journal_contribution/Metabolomics_in_the_Diagnosis_and_Prognosis_of_COVID-19/28930799CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/289307992021-06-23T12:00:00Z |
| spellingShingle | Metabolomics in the Diagnosis and Prognosis of COVID-19 Mohammad Rubayet Hasan (8602080) Biological sciences Microbiology Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics COVID-19 SARS-CoV-2 metabolomics diagnosis prognosis volatile organic compounds mass-spectrometry nuclear magnetic resonance |
| status_str | publishedVersion |
| title | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| title_full | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| title_fullStr | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| title_full_unstemmed | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| title_short | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| title_sort | Metabolomics in the Diagnosis and Prognosis of COVID-19 |
| topic | Biological sciences Microbiology Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics COVID-19 SARS-CoV-2 metabolomics diagnosis prognosis volatile organic compounds mass-spectrometry nuclear magnetic resonance |