Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends
<p dir="ltr">Alzheimer's disease (AD), a type of dementia, severely distresses different brain regions. Characterized by various neuropathologies, it interferes with cognitive functions and neuropsychiatrical controls. This progressive deterioration has negative impacts not only...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513545425649664 |
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| author | Prajakta A. Dhage (17302789) |
| author2 | Archana A. Sharbidre (17302792) Sarada P. Dakua (17302795) Shidin Balakrishnan (14150580) |
| author2_role | author author author |
| author_facet | Prajakta A. Dhage (17302789) Archana A. Sharbidre (17302792) Sarada P. Dakua (17302795) Shidin Balakrishnan (14150580) |
| author_role | author |
| dc.creator.none.fl_str_mv | Prajakta A. Dhage (17302789) Archana A. Sharbidre (17302792) Sarada P. Dakua (17302795) Shidin Balakrishnan (14150580) |
| dc.date.none.fl_str_mv | 2021-07-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.biopha.2021.111634 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Leveraging_hallmark_Alzheimer_s_molecular_targets_using_phytoconstituents_Current_perspective_and_emerging_trends/24459112 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Alzheimer's disease Phytoconstituents Tau Acetylcholine esterase Clinical trials Drug development |
| dc.title.none.fl_str_mv | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Alzheimer's disease (AD), a type of dementia, severely distresses different brain regions. Characterized by various neuropathologies, it interferes with cognitive functions and neuropsychiatrical controls. This progressive deterioration has negative impacts not only on an individual's daily activity but also on social and occupational life. The pharmacological approach has always remained in the limelight for the treatment of AD. However, this approach is condemned with several side effects. Henceforth, a change in treatment approach has become crucial. Plant-based natural products are garnering special attention due to lesser side effects associated with their use. The current review emphasizes the anti-AD properties of phytoconstituents, throws light on those under clinical trials, and compiles information on their specific mode of actions against AD-related different neuropathologies. The phytoconstituents alone or in combinations will surely help discover new potent drugs for the effective treatment of AD with lesser side effects than the currently available pharmacological treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2021.111634" target="_blank">https://dx.doi.org/10.1016/j.biopha.2021.111634</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e5f6acca81f3c840d93b8ca5af6d39e1 |
| identifier_str_mv | 10.1016/j.biopha.2021.111634 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24459112 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trendsPrajakta A. Dhage (17302789)Archana A. Sharbidre (17302792)Sarada P. Dakua (17302795)Shidin Balakrishnan (14150580)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesAlzheimer's diseasePhytoconstituentsTauAcetylcholine esteraseClinical trialsDrug development<p dir="ltr">Alzheimer's disease (AD), a type of dementia, severely distresses different brain regions. Characterized by various neuropathologies, it interferes with cognitive functions and neuropsychiatrical controls. This progressive deterioration has negative impacts not only on an individual's daily activity but also on social and occupational life. The pharmacological approach has always remained in the limelight for the treatment of AD. However, this approach is condemned with several side effects. Henceforth, a change in treatment approach has become crucial. Plant-based natural products are garnering special attention due to lesser side effects associated with their use. The current review emphasizes the anti-AD properties of phytoconstituents, throws light on those under clinical trials, and compiles information on their specific mode of actions against AD-related different neuropathologies. The phytoconstituents alone or in combinations will surely help discover new potent drugs for the effective treatment of AD with lesser side effects than the currently available pharmacological treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2021.111634" target="_blank">https://dx.doi.org/10.1016/j.biopha.2021.111634</a></p>2021-07-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.biopha.2021.111634https://figshare.com/articles/journal_contribution/Leveraging_hallmark_Alzheimer_s_molecular_targets_using_phytoconstituents_Current_perspective_and_emerging_trends/24459112CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244591122021-07-01T00:00:00Z |
| spellingShingle | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends Prajakta A. Dhage (17302789) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Alzheimer's disease Phytoconstituents Tau Acetylcholine esterase Clinical trials Drug development |
| status_str | publishedVersion |
| title | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| title_full | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| title_fullStr | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| title_full_unstemmed | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| title_short | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| title_sort | Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Alzheimer's disease Phytoconstituents Tau Acetylcholine esterase Clinical trials Drug development |