Epigenetic Risks of Medically Assisted Reproduction
<div><p>Since the birth of Louise Joy Brown, the first baby conceived via in vitro fertilization, more than 9 million children have been born worldwide using assisted reproductive technologies (ART). In vivo fertilization takes place in the maternal oviduct, where the unique physiologica...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513517943521280 |
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| author | Romualdo Sciorio (18441111) |
| author2 | Nady El Hajj (686554) |
| author2_role | author |
| author_facet | Romualdo Sciorio (18441111) Nady El Hajj (686554) |
| author_role | author |
| dc.creator.none.fl_str_mv | Romualdo Sciorio (18441111) Nady El Hajj (686554) |
| dc.date.none.fl_str_mv | 2022-04-12T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/jcm11082151 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epigenetic_Risks_of_Medically_Assisted_Reproduction/25688784 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Reproductive medicine human in vitro fertilization assisted reproductive technology epigenetics imprinting disorders |
| dc.title.none.fl_str_mv | Epigenetic Risks of Medically Assisted Reproduction |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Since the birth of Louise Joy Brown, the first baby conceived via in vitro fertilization, more than 9 million children have been born worldwide using assisted reproductive technologies (ART). In vivo fertilization takes place in the maternal oviduct, where the unique physiological conditions guarantee the healthy development of the embryo. During early embryogenesis, a major wave of epigenetic reprogramming takes place that is crucial for the correct development of the embryo. Epigenetic reprogramming is susceptible to environmental changes and non-physiological conditions such as those applied during in vitro culture, including shift in pH and temperature, oxygen tension, controlled ovarian stimulation, intracytoplasmic sperm injection, as well as preimplantation embryo manipulations for genetic testing. In the last decade, concerns were raised of a possible link between ART and increased incidence of imprinting disorders, as well as epigenetic alterations in the germ cells of infertile parents that are transmitted to the offspring following ART. The aim of this review was to present evidence from the literature regarding epigenetic errors linked to assisted reproduction treatments and their consequences on the conceived children. Furthermore, we provide an overview of disease risk associated with epigenetic or imprinting alterations in children born via ART.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Clinical Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/jcm11082151" target="_blank">https://dx.doi.org/10.3390/jcm11082151</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e7860b4dddfd5592f34c730162c98bbd |
| identifier_str_mv | 10.3390/jcm11082151 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25688784 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epigenetic Risks of Medically Assisted ReproductionRomualdo Sciorio (18441111)Nady El Hajj (686554)Biomedical and clinical sciencesReproductive medicinehuman in vitro fertilizationassisted reproductive technologyepigeneticsimprinting disorders<div><p>Since the birth of Louise Joy Brown, the first baby conceived via in vitro fertilization, more than 9 million children have been born worldwide using assisted reproductive technologies (ART). In vivo fertilization takes place in the maternal oviduct, where the unique physiological conditions guarantee the healthy development of the embryo. During early embryogenesis, a major wave of epigenetic reprogramming takes place that is crucial for the correct development of the embryo. Epigenetic reprogramming is susceptible to environmental changes and non-physiological conditions such as those applied during in vitro culture, including shift in pH and temperature, oxygen tension, controlled ovarian stimulation, intracytoplasmic sperm injection, as well as preimplantation embryo manipulations for genetic testing. In the last decade, concerns were raised of a possible link between ART and increased incidence of imprinting disorders, as well as epigenetic alterations in the germ cells of infertile parents that are transmitted to the offspring following ART. The aim of this review was to present evidence from the literature regarding epigenetic errors linked to assisted reproduction treatments and their consequences on the conceived children. Furthermore, we provide an overview of disease risk associated with epigenetic or imprinting alterations in children born via ART.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Clinical Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/jcm11082151" target="_blank">https://dx.doi.org/10.3390/jcm11082151</a></p>2022-04-12T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/jcm11082151https://figshare.com/articles/journal_contribution/Epigenetic_Risks_of_Medically_Assisted_Reproduction/25688784CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256887842022-04-12T03:00:00Z |
| spellingShingle | Epigenetic Risks of Medically Assisted Reproduction Romualdo Sciorio (18441111) Biomedical and clinical sciences Reproductive medicine human in vitro fertilization assisted reproductive technology epigenetics imprinting disorders |
| status_str | publishedVersion |
| title | Epigenetic Risks of Medically Assisted Reproduction |
| title_full | Epigenetic Risks of Medically Assisted Reproduction |
| title_fullStr | Epigenetic Risks of Medically Assisted Reproduction |
| title_full_unstemmed | Epigenetic Risks of Medically Assisted Reproduction |
| title_short | Epigenetic Risks of Medically Assisted Reproduction |
| title_sort | Epigenetic Risks of Medically Assisted Reproduction |
| topic | Biomedical and clinical sciences Reproductive medicine human in vitro fertilization assisted reproductive technology epigenetics imprinting disorders |