In silico characterization of the novel SDR42E1 as a potential vitamin D modulator
<p dir="ltr">The short-chain dehydrogenase/reductase (SDR) superfamily encompasses enzymes that play essential roles in the metabolism of steroid hormones and lipids. Despite an enigmatic function, recent genetic studies have linked the novel SDR 42 extended-1 (SDR42E1) gene to 25-hy...
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2024
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| _version_ | 1864513510334005248 |
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| author | Nagham Nafiz Hendi (17064261) |
| author2 | Georges Nemer (295984) |
| author2_role | author |
| author_facet | Nagham Nafiz Hendi (17064261) Georges Nemer (295984) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nagham Nafiz Hendi (17064261) Georges Nemer (295984) |
| dc.date.none.fl_str_mv | 2024-01-08T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jsbmb.2023.106447 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/In_silico_characterization_of_the_novel_SDR42E1_as_a_potential_vitamin_D_modulator/26355064 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Bioinformatics and computational biology SDR42E1 Vitamin D skin biosynthesis Bioinformatics Molecular docking Evolutionary conservation |
| dc.title.none.fl_str_mv | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The short-chain dehydrogenase/reductase (SDR) superfamily encompasses enzymes that play essential roles in the metabolism of steroid hormones and lipids. Despite an enigmatic function, recent genetic studies have linked the novel SDR 42 extended-1 (SDR42E1) gene to 25-hydroxyvitamin D levels. This study investigated the potential <i>SDR42E1</i> functions and interactions with vitamin D using bioinformatics and molecular docking studies. Phylogenetic analysis unveiled that the nucleotide sequences of human SDR42E1 exhibit high evolutionary conservation across nematodes and fruit flies. Molecular docking analysis identified strong binding affinities between SDR42E1 and its orthologs with vitamin D3 and essential precursors, 8-dehydrocholesterol, followed by 7-dehydrocholesterol and 25-hydroxyvitamin D. The hydrophobic interactions observed between the protein residues and vitamin D compounds supported the predicted transmembrane localization of SDR42E1. Our investigation provides valuable insights into the potential role of SDR42E1 in skin vitamin D biosynthesis throughout species. This provides the foundation for future research and development of targeted therapies for vitamin D deficiency and related health conditions.</p><h2>Other Information</h2><p dir="ltr">Published in: The Journal of Steroid Biochemistry and Molecular Biology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jsbmb.2023.106447" target="_blank">https://dx.doi.org/10.1016/j.jsbmb.2023.106447</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e82a2b0c103e62257caf9fc97710f426 |
| identifier_str_mv | 10.1016/j.jsbmb.2023.106447 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26355064 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | In silico characterization of the novel SDR42E1 as a potential vitamin D modulatorNagham Nafiz Hendi (17064261)Georges Nemer (295984)Biological sciencesBiochemistry and cell biologyBioinformatics and computational biologySDR42E1Vitamin D skin biosynthesisBioinformaticsMolecular dockingEvolutionary conservation<p dir="ltr">The short-chain dehydrogenase/reductase (SDR) superfamily encompasses enzymes that play essential roles in the metabolism of steroid hormones and lipids. Despite an enigmatic function, recent genetic studies have linked the novel SDR 42 extended-1 (SDR42E1) gene to 25-hydroxyvitamin D levels. This study investigated the potential <i>SDR42E1</i> functions and interactions with vitamin D using bioinformatics and molecular docking studies. Phylogenetic analysis unveiled that the nucleotide sequences of human SDR42E1 exhibit high evolutionary conservation across nematodes and fruit flies. Molecular docking analysis identified strong binding affinities between SDR42E1 and its orthologs with vitamin D3 and essential precursors, 8-dehydrocholesterol, followed by 7-dehydrocholesterol and 25-hydroxyvitamin D. The hydrophobic interactions observed between the protein residues and vitamin D compounds supported the predicted transmembrane localization of SDR42E1. Our investigation provides valuable insights into the potential role of SDR42E1 in skin vitamin D biosynthesis throughout species. This provides the foundation for future research and development of targeted therapies for vitamin D deficiency and related health conditions.</p><h2>Other Information</h2><p dir="ltr">Published in: The Journal of Steroid Biochemistry and Molecular Biology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jsbmb.2023.106447" target="_blank">https://dx.doi.org/10.1016/j.jsbmb.2023.106447</a></p>2024-01-08T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jsbmb.2023.106447https://figshare.com/articles/journal_contribution/In_silico_characterization_of_the_novel_SDR42E1_as_a_potential_vitamin_D_modulator/26355064CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/263550642024-01-08T06:00:00Z |
| spellingShingle | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator Nagham Nafiz Hendi (17064261) Biological sciences Biochemistry and cell biology Bioinformatics and computational biology SDR42E1 Vitamin D skin biosynthesis Bioinformatics Molecular docking Evolutionary conservation |
| status_str | publishedVersion |
| title | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| title_full | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| title_fullStr | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| title_full_unstemmed | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| title_short | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| title_sort | In silico characterization of the novel SDR42E1 as a potential vitamin D modulator |
| topic | Biological sciences Biochemistry and cell biology Bioinformatics and computational biology SDR42E1 Vitamin D skin biosynthesis Bioinformatics Molecular docking Evolutionary conservation |