Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation
<p dir="ltr">Vitamin B<sub>12</sub>(cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B<sub>12</sub> exists in several forms: methylcobalamin (MeCbl), adenos...
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2024
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| _version_ | 1864513543086276608 |
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| author | Mazhar Salim Al Zoubi (18024364) |
| author2 | Mus’aab A. Al-Oun (21839387) Fatima Yacoub Abusahyoun (21839390) Manal Issam Abualarja (21839393) Asmaa Al Smadi (21839396) Bahaa Al-Trad (3574976) Sura A. Awadin (21839399) Khalid Al-Batayneh (21839402) Mai Elaarag (17807390) Raed M. Al-Zoubi (2037490) |
| author2_role | author author author author author author author author author |
| author_facet | Mazhar Salim Al Zoubi (18024364) Mus’aab A. Al-Oun (21839387) Fatima Yacoub Abusahyoun (21839390) Manal Issam Abualarja (21839393) Asmaa Al Smadi (21839396) Bahaa Al-Trad (3574976) Sura A. Awadin (21839399) Khalid Al-Batayneh (21839402) Mai Elaarag (17807390) Raed M. Al-Zoubi (2037490) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mazhar Salim Al Zoubi (18024364) Mus’aab A. Al-Oun (21839387) Fatima Yacoub Abusahyoun (21839390) Manal Issam Abualarja (21839393) Asmaa Al Smadi (21839396) Bahaa Al-Trad (3574976) Sura A. Awadin (21839399) Khalid Al-Batayneh (21839402) Mai Elaarag (17807390) Raed M. Al-Zoubi (2037490) |
| dc.date.none.fl_str_mv | 2024-04-18T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2024/8827402 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Exploring_the_Impact_of_Cigarette_Smoke_Extracts_on_Vitamin_B_sub_12_sub_Insights_into_the_Transformation_of_Methylcobalamin_and_Hydroxycobalamin_to_Cyanocobalamin_through_i_In_Vitro_i_Evaluation/29713826 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Vitamin B12 Cobalamin Methylcobalamin (MeCbl) Hydroxycobalamin (OHCbl) Cyanocobalamin (CNCbl) Adenosylcobalamin (AdoCbl) |
| dc.title.none.fl_str_mv | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Vitamin B<sub>12</sub>(cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B<sub>12</sub> exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). This study aimed to evaluate the effect of cigarette smoke on the chemical structure of methylcobalamin and hydroxycobalamin forms of vitamin B<sub>12</sub>. MeCbl and OHCbl were markedly affected by exposure to cigarette smoke. The resemblance of the Rt between MeCbl and OHCbl and CNCbl indicates that exposure to cigarette smoke extracts chemically alters MeCbl and OHCbl to CNCbl, warranting <i>in vivo</i> research investigations.</p><p><br></p><h2>Other Information</h2><p dir="ltr">Published in: Biochemistry Research International<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2024/8827402" target="_blank">https://dx.doi.org/10.1155/2024/8827402</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e88b188865de766d08f9fb5502a23668 |
| identifier_str_mv | 10.1155/2024/8827402 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29713826 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>EvaluationMazhar Salim Al Zoubi (18024364)Mus’aab A. Al-Oun (21839387)Fatima Yacoub Abusahyoun (21839390)Manal Issam Abualarja (21839393)Asmaa Al Smadi (21839396)Bahaa Al-Trad (3574976)Sura A. Awadin (21839399)Khalid Al-Batayneh (21839402)Mai Elaarag (17807390)Raed M. Al-Zoubi (2037490)Biomedical and clinical sciencesMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencesVitamin B12CobalaminMethylcobalamin (MeCbl)Hydroxycobalamin (OHCbl)Cyanocobalamin (CNCbl)Adenosylcobalamin (AdoCbl)<p dir="ltr">Vitamin B<sub>12</sub>(cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B<sub>12</sub> exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). This study aimed to evaluate the effect of cigarette smoke on the chemical structure of methylcobalamin and hydroxycobalamin forms of vitamin B<sub>12</sub>. MeCbl and OHCbl were markedly affected by exposure to cigarette smoke. The resemblance of the Rt between MeCbl and OHCbl and CNCbl indicates that exposure to cigarette smoke extracts chemically alters MeCbl and OHCbl to CNCbl, warranting <i>in vivo</i> research investigations.</p><p><br></p><h2>Other Information</h2><p dir="ltr">Published in: Biochemistry Research International<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2024/8827402" target="_blank">https://dx.doi.org/10.1155/2024/8827402</a></p>2024-04-18T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2024/8827402https://figshare.com/articles/journal_contribution/Exploring_the_Impact_of_Cigarette_Smoke_Extracts_on_Vitamin_B_sub_12_sub_Insights_into_the_Transformation_of_Methylcobalamin_and_Hydroxycobalamin_to_Cyanocobalamin_through_i_In_Vitro_i_Evaluation/29713826CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297138262024-04-18T09:00:00Z |
| spellingShingle | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation Mazhar Salim Al Zoubi (18024364) Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Vitamin B12 Cobalamin Methylcobalamin (MeCbl) Hydroxycobalamin (OHCbl) Cyanocobalamin (CNCbl) Adenosylcobalamin (AdoCbl) |
| status_str | publishedVersion |
| title | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| title_full | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| title_fullStr | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| title_full_unstemmed | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| title_short | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| title_sort | Exploring the Impact of Cigarette Smoke Extracts on Vitamin B<sub>12</sub>: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through <i>In Vitro </i>Evaluation |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Vitamin B12 Cobalamin Methylcobalamin (MeCbl) Hydroxycobalamin (OHCbl) Cyanocobalamin (CNCbl) Adenosylcobalamin (AdoCbl) |