WNT signaling at the intersection between neurogenesis and brain tumorigenesis
<div><p>Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a tightly regulated process that secures the accuracy of cell division and eliminates cells that undergo m...
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2022
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| _version_ | 1864513519073886208 |
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| author | Maisa I. Alkailani (15070764) |
| author2 | Mohamed Aittaleb (18007087) Fadel Tissir (245153) |
| author2_role | author author |
| author_facet | Maisa I. Alkailani (15070764) Mohamed Aittaleb (18007087) Fadel Tissir (245153) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maisa I. Alkailani (15070764) Mohamed Aittaleb (18007087) Fadel Tissir (245153) |
| dc.date.none.fl_str_mv | 2022-10-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnmol.2022.1017568 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/WNT_signaling_at_the_intersection_between_neurogenesis_and_brain_tumorigenesis/25659090 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Wnt/β-catenin Wnt/PCP WNT/calcium neural progenitor cells neurogenesis glioma glioblastoma therapy |
| dc.title.none.fl_str_mv | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a tightly regulated process that secures the accuracy of cell division and eliminates cells that undergo mitotic errors. Abnormalities in the molecular mechanisms controlling this process can trigger aneuploidy and genome instability, leading to neoplastic transformation. Mutations that affect cell adhesion, polarity, or migration enhance the invasive potential and favor the progression of tumors. Here, we review recent evidence of the WNT pathway’s involvement in both neurogenesis and tumorigenesis and discuss the experimental progress on therapeutic opportunities targeting components of this pathway.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Frontiers in Molecular Neuroscience<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnmol.2022.1017568" target="_blank">https://dx.doi.org/10.3389/fnmol.2022.1017568</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e8967e446538a8a6a62a21e692f4addc |
| identifier_str_mv | 10.3389/fnmol.2022.1017568 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25659090 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | WNT signaling at the intersection between neurogenesis and brain tumorigenesisMaisa I. Alkailani (15070764)Mohamed Aittaleb (18007087)Fadel Tissir (245153)Biomedical and clinical sciencesNeurosciencesWnt/β-cateninWnt/PCPWNT/calciumneural progenitor cellsneurogenesisgliomaglioblastoma therapy<div><p>Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a tightly regulated process that secures the accuracy of cell division and eliminates cells that undergo mitotic errors. Abnormalities in the molecular mechanisms controlling this process can trigger aneuploidy and genome instability, leading to neoplastic transformation. Mutations that affect cell adhesion, polarity, or migration enhance the invasive potential and favor the progression of tumors. Here, we review recent evidence of the WNT pathway’s involvement in both neurogenesis and tumorigenesis and discuss the experimental progress on therapeutic opportunities targeting components of this pathway.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Frontiers in Molecular Neuroscience<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnmol.2022.1017568" target="_blank">https://dx.doi.org/10.3389/fnmol.2022.1017568</a></p>2022-10-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fnmol.2022.1017568https://figshare.com/articles/journal_contribution/WNT_signaling_at_the_intersection_between_neurogenesis_and_brain_tumorigenesis/25659090CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256590902022-10-04T03:00:00Z |
| spellingShingle | WNT signaling at the intersection between neurogenesis and brain tumorigenesis Maisa I. Alkailani (15070764) Biomedical and clinical sciences Neurosciences Wnt/β-catenin Wnt/PCP WNT/calcium neural progenitor cells neurogenesis glioma glioblastoma therapy |
| status_str | publishedVersion |
| title | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| title_full | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| title_fullStr | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| title_full_unstemmed | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| title_short | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| title_sort | WNT signaling at the intersection between neurogenesis and brain tumorigenesis |
| topic | Biomedical and clinical sciences Neurosciences Wnt/β-catenin Wnt/PCP WNT/calcium neural progenitor cells neurogenesis glioma glioblastoma therapy |