Ion Transporters, Channelopathies, and Glucose Disorders
<p dir="ltr">Ion channels and transporters play essential roles in excitable cells including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, for example, potassium KATP channels link the metabolic signals generated inside the cell to...
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2019
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| _version_ | 1864513523105660928 |
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| author | Huseyin Demirbilek (566044) |
| author2 | Sonya Galcheva (14172121) Dogus Vuralli (18112807) Sara Al-Khawaga (4792761) Khalid Hussain (110443) |
| author2_role | author author author author |
| author_facet | Huseyin Demirbilek (566044) Sonya Galcheva (14172121) Dogus Vuralli (18112807) Sara Al-Khawaga (4792761) Khalid Hussain (110443) |
| author_role | author |
| dc.creator.none.fl_str_mv | Huseyin Demirbilek (566044) Sonya Galcheva (14172121) Dogus Vuralli (18112807) Sara Al-Khawaga (4792761) Khalid Hussain (110443) |
| dc.date.none.fl_str_mv | 2019-05-27T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms20102590 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Ion_Transporters_Channelopathies_and_Glucose_Disorders/25348279 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Clinical sciences Medical physiology beta cell KATP channel voltage-gated calcium channels membrane transporters neonatal diabetes hyperinsulinaemic hypoglycaemia |
| dc.title.none.fl_str_mv | Ion Transporters, Channelopathies, and Glucose Disorders |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Ion channels and transporters play essential roles in excitable cells including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, for example, potassium KATP channels link the metabolic signals generated inside the cell to changes in the beta-cell membrane potential, and ultimately regulate insulin secretion. Mutations in the genes encoding some ion transporter and channel proteins lead to disorders of glucose homeostasis (hyperinsulinaemic hypoglycaemia and different forms of diabetes mellitus). Pancreatic KATP, Non-KATP, and some calcium channelopathies and MCT1 transporter defects can lead to various forms of hyperinsulinaemic hypoglycaemia (HH). Mutations in the genes encoding the pancreatic KATP channels can also lead to different types of diabetes (including neonatal diabetes mellitus (NDM) and Maturity Onset Diabetes of the Young, MODY), and defects in the solute carrier family 2 member 2 (SLC2A2) leads to diabetes mellitus as part of the Fanconi–Bickel syndrome. Variants or polymorphisms in some ion channel genes and transporters have been reported in association with type 2 diabetes mellitus.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms20102590" target="_blank">https://dx.doi.org/10.3390/ijms20102590</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_e89b079b2ce61f26a3820f608f1bb2a6 |
| identifier_str_mv | 10.3390/ijms20102590 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25348279 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Ion Transporters, Channelopathies, and Glucose DisordersHuseyin Demirbilek (566044)Sonya Galcheva (14172121)Dogus Vuralli (18112807)Sara Al-Khawaga (4792761)Khalid Hussain (110443)Biological sciencesBiochemistry and cell biologyGeneticsBiomedical and clinical sciencesClinical sciencesMedical physiologybeta cellKATP channelvoltage-gated calcium channelsmembrane transportersneonatal diabeteshyperinsulinaemic hypoglycaemia<p dir="ltr">Ion channels and transporters play essential roles in excitable cells including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, for example, potassium KATP channels link the metabolic signals generated inside the cell to changes in the beta-cell membrane potential, and ultimately regulate insulin secretion. Mutations in the genes encoding some ion transporter and channel proteins lead to disorders of glucose homeostasis (hyperinsulinaemic hypoglycaemia and different forms of diabetes mellitus). Pancreatic KATP, Non-KATP, and some calcium channelopathies and MCT1 transporter defects can lead to various forms of hyperinsulinaemic hypoglycaemia (HH). Mutations in the genes encoding the pancreatic KATP channels can also lead to different types of diabetes (including neonatal diabetes mellitus (NDM) and Maturity Onset Diabetes of the Young, MODY), and defects in the solute carrier family 2 member 2 (SLC2A2) leads to diabetes mellitus as part of the Fanconi–Bickel syndrome. Variants or polymorphisms in some ion channel genes and transporters have been reported in association with type 2 diabetes mellitus.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms20102590" target="_blank">https://dx.doi.org/10.3390/ijms20102590</a></p>2019-05-27T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms20102590https://figshare.com/articles/journal_contribution/Ion_Transporters_Channelopathies_and_Glucose_Disorders/25348279CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253482792019-05-27T03:00:00Z |
| spellingShingle | Ion Transporters, Channelopathies, and Glucose Disorders Huseyin Demirbilek (566044) Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Clinical sciences Medical physiology beta cell KATP channel voltage-gated calcium channels membrane transporters neonatal diabetes hyperinsulinaemic hypoglycaemia |
| status_str | publishedVersion |
| title | Ion Transporters, Channelopathies, and Glucose Disorders |
| title_full | Ion Transporters, Channelopathies, and Glucose Disorders |
| title_fullStr | Ion Transporters, Channelopathies, and Glucose Disorders |
| title_full_unstemmed | Ion Transporters, Channelopathies, and Glucose Disorders |
| title_short | Ion Transporters, Channelopathies, and Glucose Disorders |
| title_sort | Ion Transporters, Channelopathies, and Glucose Disorders |
| topic | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Clinical sciences Medical physiology beta cell KATP channel voltage-gated calcium channels membrane transporters neonatal diabetes hyperinsulinaemic hypoglycaemia |