Stress granules counteract senescence by sequestration of PAI‐1
<p dir="ltr">Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data re...
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2018
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| _version_ | 1864513512973271040 |
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| author | Amr Omer (18629374) |
| author2 | Devang Patel (2432920) Xian Jin Lian (18711976) Jason Sadek (18629365) Sergio Di Marco (387749) Arnim Pause (265677) Myriam Gorospe (27942) Imed Eddine Gallouzi (14908101) |
| author2_role | author author author author author author author |
| author_facet | Amr Omer (18629374) Devang Patel (2432920) Xian Jin Lian (18711976) Jason Sadek (18629365) Sergio Di Marco (387749) Arnim Pause (265677) Myriam Gorospe (27942) Imed Eddine Gallouzi (14908101) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amr Omer (18629374) Devang Patel (2432920) Xian Jin Lian (18711976) Jason Sadek (18629365) Sergio Di Marco (387749) Arnim Pause (265677) Myriam Gorospe (27942) Imed Eddine Gallouzi (14908101) |
| dc.date.none.fl_str_mv | 2018-03-29T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.15252/embr.201744722 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Stress_granules_counteract_senescence_by_sequestration_of_PAI_1/25953607 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Psychology Applied and developmental psychology PAI-1 senescence stress granules stress response |
| dc.title.none.fl_str_mv | Stress granules counteract senescence by sequestration of PAI‐1 |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data reveal a novel interplay between senescence and the stress response that affects both the progression of senescence and the behavior of senescent cells. We show that constitutive exposure to stress induces the formation of stress granules (SGs) in proliferative and presenescent cells, but not in fully senescent cells. Stress granule assembly alone is sufficient to decrease the number of senescent cells without affecting the expression of bona fide senescence markers. SG‐mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor‐1 (PAI‐1), a known promoter of senescence, to these entities. PAI‐1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non‐senescent state. Together, our data indicate that SGs may be targets of intervention to modulate senescence in order to impair or prevent its deleterious effects.</p><h2>Other Information</h2><p dir="ltr">Published in: EMBO reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.15252/embr.201744722" target="_blank">https://dx.doi.org/10.15252/embr.201744722</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ea5938b3cb680acc0cb583765eeab4f1 |
| identifier_str_mv | 10.15252/embr.201744722 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25953607 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Stress granules counteract senescence by sequestration of PAI‐1Amr Omer (18629374)Devang Patel (2432920)Xian Jin Lian (18711976)Jason Sadek (18629365)Sergio Di Marco (387749)Arnim Pause (265677)Myriam Gorospe (27942)Imed Eddine Gallouzi (14908101)PsychologyApplied and developmental psychologyPAI-1senescencestress granulesstress response<p dir="ltr">Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data reveal a novel interplay between senescence and the stress response that affects both the progression of senescence and the behavior of senescent cells. We show that constitutive exposure to stress induces the formation of stress granules (SGs) in proliferative and presenescent cells, but not in fully senescent cells. Stress granule assembly alone is sufficient to decrease the number of senescent cells without affecting the expression of bona fide senescence markers. SG‐mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor‐1 (PAI‐1), a known promoter of senescence, to these entities. PAI‐1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non‐senescent state. Together, our data indicate that SGs may be targets of intervention to modulate senescence in order to impair or prevent its deleterious effects.</p><h2>Other Information</h2><p dir="ltr">Published in: EMBO reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.15252/embr.201744722" target="_blank">https://dx.doi.org/10.15252/embr.201744722</a></p>2018-03-29T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.15252/embr.201744722https://figshare.com/articles/journal_contribution/Stress_granules_counteract_senescence_by_sequestration_of_PAI_1/25953607CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259536072018-03-29T09:00:00Z |
| spellingShingle | Stress granules counteract senescence by sequestration of PAI‐1 Amr Omer (18629374) Psychology Applied and developmental psychology PAI-1 senescence stress granules stress response |
| status_str | publishedVersion |
| title | Stress granules counteract senescence by sequestration of PAI‐1 |
| title_full | Stress granules counteract senescence by sequestration of PAI‐1 |
| title_fullStr | Stress granules counteract senescence by sequestration of PAI‐1 |
| title_full_unstemmed | Stress granules counteract senescence by sequestration of PAI‐1 |
| title_short | Stress granules counteract senescence by sequestration of PAI‐1 |
| title_sort | Stress granules counteract senescence by sequestration of PAI‐1 |
| topic | Psychology Applied and developmental psychology PAI-1 senescence stress granules stress response |