The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy
<p>Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that is responsible for tumor formation, progression and resistance to therapies. The interaction between CSCs/CICs and tumor microenvironment (TME) can sustain “stemness” properties and promote th...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2019
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513567186747392 |
|---|---|
| author | Shilpa Ravindran (3627299) |
| author2 | Saad Rasool (9764093) Cristina Maccalli (2632465) |
| author2_role | author author |
| author_facet | Shilpa Ravindran (3627299) Saad Rasool (9764093) Cristina Maccalli (2632465) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shilpa Ravindran (3627299) Saad Rasool (9764093) Cristina Maccalli (2632465) |
| dc.date.none.fl_str_mv | 2019-11-22T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s12307-019-00233-1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Cross_Talk_between_Cancer_Stem_Cells_Cancer_Initiating_Cells_and_Tumor_Microenvironment_The_Missing_Piece_of_the_Puzzle_for_the_Efficient_Targeting_of_these_Cells_with_Immunotherapy/21597672 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Medical biotechnology Oncology and carcinogenesis Cancer stem cells/Cancer initiating cells Immunosurveillance Adaptive immune responses Innate immune responses Tumor microenvironment Immunotherapy |
| dc.title.none.fl_str_mv | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that is responsible for tumor formation, progression and resistance to therapies. The interaction between CSCs/CICs and tumor microenvironment (TME) can sustain “stemness” properties and promote their survival and plasticity. This cross-talk is also pivotal in regulating and modulating CSC/CIC properties. This review will provide an overview of the mechanisms underlying the mutual interaction between CSCs/CICs and TME. Particular focus will be dedicated to the immunological profile of CSCs/CICs and its role in orchestrating cancer immunosurveillance. Moreover, the available immunotherapy strategies that can target CSCs/CICs and of their possible implementation will be discussed. Overall, the dissection of the mechanisms regulating the CSC/CIC-TME interaction is warranted to understand the plasticity and immunoregulatory properties of stem-like tumor cells and to achieve complete eradications of tumors through the optimization of immunotherapy.</p><h2>Other Information</h2> <p> Published in: Cancer Microenvironment<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s12307-019-00233-1" target="_blank">http://dx.doi.org/10.1007/s12307-019-00233-1</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ea660716c63b9d4584a2ae355955a44c |
| identifier_str_mv | 10.1007/s12307-019-00233-1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597672 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with ImmunotherapyShilpa Ravindran (3627299)Saad Rasool (9764093)Cristina Maccalli (2632465)Biomedical and clinical sciencesImmunologyMedical biotechnologyOncology and carcinogenesisCancer stem cells/Cancer initiating cellsImmunosurveillanceAdaptive immune responsesInnate immune responsesTumor microenvironmentImmunotherapy<p>Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that is responsible for tumor formation, progression and resistance to therapies. The interaction between CSCs/CICs and tumor microenvironment (TME) can sustain “stemness” properties and promote their survival and plasticity. This cross-talk is also pivotal in regulating and modulating CSC/CIC properties. This review will provide an overview of the mechanisms underlying the mutual interaction between CSCs/CICs and TME. Particular focus will be dedicated to the immunological profile of CSCs/CICs and its role in orchestrating cancer immunosurveillance. Moreover, the available immunotherapy strategies that can target CSCs/CICs and of their possible implementation will be discussed. Overall, the dissection of the mechanisms regulating the CSC/CIC-TME interaction is warranted to understand the plasticity and immunoregulatory properties of stem-like tumor cells and to achieve complete eradications of tumors through the optimization of immunotherapy.</p><h2>Other Information</h2> <p> Published in: Cancer Microenvironment<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s12307-019-00233-1" target="_blank">http://dx.doi.org/10.1007/s12307-019-00233-1</a></p>2019-11-22T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s12307-019-00233-1https://figshare.com/articles/journal_contribution/The_Cross_Talk_between_Cancer_Stem_Cells_Cancer_Initiating_Cells_and_Tumor_Microenvironment_The_Missing_Piece_of_the_Puzzle_for_the_Efficient_Targeting_of_these_Cells_with_Immunotherapy/21597672CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215976722019-11-22T06:00:00Z |
| spellingShingle | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy Shilpa Ravindran (3627299) Biomedical and clinical sciences Immunology Medical biotechnology Oncology and carcinogenesis Cancer stem cells/Cancer initiating cells Immunosurveillance Adaptive immune responses Innate immune responses Tumor microenvironment Immunotherapy |
| status_str | publishedVersion |
| title | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| title_full | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| title_fullStr | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| title_full_unstemmed | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| title_short | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| title_sort | The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy |
| topic | Biomedical and clinical sciences Immunology Medical biotechnology Oncology and carcinogenesis Cancer stem cells/Cancer initiating cells Immunosurveillance Adaptive immune responses Innate immune responses Tumor microenvironment Immunotherapy |