The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis
<p dir="ltr">Maternal anaemia is a significant global health issue that adversely affects both maternal and foetal outcomes, particularly, intrauterine growth restriction (IUGR). This systematic review and meta‐analysis aimed to consolidate existing evidence on the impact of maternal...
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2025
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| _version_ | 1864513534560305152 |
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| author | Rajeev Jayalakshmi (22466752) |
| author2 | Shilpa Gaidhane (745829) Suhas Ballal (19463612) Sanjay Kumar (8853) Mahakshit Bhat (22391929) Shilpa Sharma (2098804) M. Ravi Kumar (592077) Sarvesh Rustagi (17471712) Mahalaqua Nazli Khatib (9714860) Nishant Rai (20436608) Sanjit Sah (19709571) Sorabh Lakhanpal (19709577) Hashem Abu Serhan (15993651) Ganesh Bushi (19709574) Muhammed Shabil (16677981) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Rajeev Jayalakshmi (22466752) Shilpa Gaidhane (745829) Suhas Ballal (19463612) Sanjay Kumar (8853) Mahakshit Bhat (22391929) Shilpa Sharma (2098804) M. Ravi Kumar (592077) Sarvesh Rustagi (17471712) Mahalaqua Nazli Khatib (9714860) Nishant Rai (20436608) Sanjit Sah (19709571) Sorabh Lakhanpal (19709577) Hashem Abu Serhan (15993651) Ganesh Bushi (19709574) Muhammed Shabil (16677981) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rajeev Jayalakshmi (22466752) Shilpa Gaidhane (745829) Suhas Ballal (19463612) Sanjay Kumar (8853) Mahakshit Bhat (22391929) Shilpa Sharma (2098804) M. Ravi Kumar (592077) Sarvesh Rustagi (17471712) Mahalaqua Nazli Khatib (9714860) Nishant Rai (20436608) Sanjit Sah (19709571) Sorabh Lakhanpal (19709577) Hashem Abu Serhan (15993651) Ganesh Bushi (19709574) Muhammed Shabil (16677981) |
| dc.date.none.fl_str_mv | 2025-04-15T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/mcn.13787 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Effect_of_Maternal_Haemoglobinopathies_and_Iron_Deficiency_Anaemia_on_Foetal_Growth_Restriction_A_Systematic_Review_and_Meta_Analysis/30405619 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Reproductive medicine Health sciences Epidemiology Public health anaemia good health and well‐being intrauterine growth restriction meta‐analysis |
| dc.title.none.fl_str_mv | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Maternal anaemia is a significant global health issue that adversely affects both maternal and foetal outcomes, particularly, intrauterine growth restriction (IUGR). This systematic review and meta‐analysis aimed to consolidate existing evidence on the impact of maternal anaemia on the risk of IUGR. We conducted a comprehensive search across PubMed, Embase, Cochrane and Web of Science until 28 February 2024. Eligible studies included observational designs that reported maternal anaemia and its association with IUGR or small for gestational age (SGA) outcomes. The pooled odds ratios (ORs) were calculated using a random‐effects model and heterogeneity was assessed with the <i>I²</i> statistic. The R software (version 4.3) was used for statistical analyses. A total of 38 studies involving 3,871,849 anaemic and 27,978,450 non‐anaemic pregnant women were included. The pooled analysis demonstrated that anaemia in pregnancy is associated with a significantly increased risk of IUGR (OR = 1.30, 95% CI: 1.05–1.62, <i>I²</i> = 97%). Subgroup analyses by anaemia severity showed non‐significant associations for mild (OR = 0.84, 95% CI: 0.58–1.23) and moderate anaemia (OR = 0.98, 95% CI: 0.48–1.98), while severe anaemia indicated a higher, though non‐significant, risk of IUGR (OR = 1.42, 95% CI: 0.69–2.93). Maternal anaemia is associated with a heightened risk of IUGR, highlighting the critical need for effective management and early intervention strategies within prenatal care settings. Future research should focus on elucidating the effects of different severities of anaemia on birth outcomes, including IUGR and long‐term effects later in life.</p><h2>Other Information</h2><p dir="ltr">Published in: Maternal & Child Nutrition<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/mcn.13787" target="_blank">https://dx.doi.org/10.1111/mcn.13787</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_eb0e4bdc2aad727650c615c15fad3283 |
| identifier_str_mv | 10.1111/mcn.13787 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30405619 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐AnalysisRajeev Jayalakshmi (22466752)Shilpa Gaidhane (745829)Suhas Ballal (19463612)Sanjay Kumar (8853)Mahakshit Bhat (22391929)Shilpa Sharma (2098804)M. Ravi Kumar (592077)Sarvesh Rustagi (17471712)Mahalaqua Nazli Khatib (9714860)Nishant Rai (20436608)Sanjit Sah (19709571)Sorabh Lakhanpal (19709577)Hashem Abu Serhan (15993651)Ganesh Bushi (19709574)Muhammed Shabil (16677981)Biomedical and clinical sciencesReproductive medicineHealth sciencesEpidemiologyPublic healthanaemiagood health and well‐beingintrauterine growth restrictionmeta‐analysis<p dir="ltr">Maternal anaemia is a significant global health issue that adversely affects both maternal and foetal outcomes, particularly, intrauterine growth restriction (IUGR). This systematic review and meta‐analysis aimed to consolidate existing evidence on the impact of maternal anaemia on the risk of IUGR. We conducted a comprehensive search across PubMed, Embase, Cochrane and Web of Science until 28 February 2024. Eligible studies included observational designs that reported maternal anaemia and its association with IUGR or small for gestational age (SGA) outcomes. The pooled odds ratios (ORs) were calculated using a random‐effects model and heterogeneity was assessed with the <i>I²</i> statistic. The R software (version 4.3) was used for statistical analyses. A total of 38 studies involving 3,871,849 anaemic and 27,978,450 non‐anaemic pregnant women were included. The pooled analysis demonstrated that anaemia in pregnancy is associated with a significantly increased risk of IUGR (OR = 1.30, 95% CI: 1.05–1.62, <i>I²</i> = 97%). Subgroup analyses by anaemia severity showed non‐significant associations for mild (OR = 0.84, 95% CI: 0.58–1.23) and moderate anaemia (OR = 0.98, 95% CI: 0.48–1.98), while severe anaemia indicated a higher, though non‐significant, risk of IUGR (OR = 1.42, 95% CI: 0.69–2.93). Maternal anaemia is associated with a heightened risk of IUGR, highlighting the critical need for effective management and early intervention strategies within prenatal care settings. Future research should focus on elucidating the effects of different severities of anaemia on birth outcomes, including IUGR and long‐term effects later in life.</p><h2>Other Information</h2><p dir="ltr">Published in: Maternal & Child Nutrition<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/mcn.13787" target="_blank">https://dx.doi.org/10.1111/mcn.13787</a></p>2025-04-15T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/mcn.13787https://figshare.com/articles/journal_contribution/The_Effect_of_Maternal_Haemoglobinopathies_and_Iron_Deficiency_Anaemia_on_Foetal_Growth_Restriction_A_Systematic_Review_and_Meta_Analysis/30405619CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304056192025-04-15T09:00:00Z |
| spellingShingle | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis Rajeev Jayalakshmi (22466752) Biomedical and clinical sciences Reproductive medicine Health sciences Epidemiology Public health anaemia good health and well‐being intrauterine growth restriction meta‐analysis |
| status_str | publishedVersion |
| title | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| title_full | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| title_fullStr | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| title_short | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| title_sort | The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta‐Analysis |
| topic | Biomedical and clinical sciences Reproductive medicine Health sciences Epidemiology Public health anaemia good health and well‐being intrauterine growth restriction meta‐analysis |