Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis
<h3>Purpose</h3><p dir="ltr">Intraocular pressure (IOP) control is paramount during ophthalmic surgeries to ensure successful outcomes and prevent complications. Intravenous mannitol has been explored for its ability to manage IOP fluctuations in both vitrectomized and no...
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2024
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| author | HASHEM ABU SERHAN (19737499) |
| author2 | PARUL CHAWLA GUPTA (19737502) MAHALAQUA NAZLI KHATIB (19737505) BIJAYA K. PADHI (19737508) SHILPA GAIDHANE (19737511) QUAZI SYED ZAHIRUDDIN (19737514) ABHAY M. GAIDHANE (19737517) NEELIMA KUKRETI (19737520) SARVESH RUSTAGI (19737523) PRAKASINI SATAPATHY (19737526) |
| author2_role | author author author author author author author author author |
| author_facet | HASHEM ABU SERHAN (19737499) PARUL CHAWLA GUPTA (19737502) MAHALAQUA NAZLI KHATIB (19737505) BIJAYA K. PADHI (19737508) SHILPA GAIDHANE (19737511) QUAZI SYED ZAHIRUDDIN (19737514) ABHAY M. GAIDHANE (19737517) NEELIMA KUKRETI (19737520) SARVESH RUSTAGI (19737523) PRAKASINI SATAPATHY (19737526) |
| author_role | author |
| dc.creator.none.fl_str_mv | HASHEM ABU SERHAN (19737499) PARUL CHAWLA GUPTA (19737502) MAHALAQUA NAZLI KHATIB (19737505) BIJAYA K. PADHI (19737508) SHILPA GAIDHANE (19737511) QUAZI SYED ZAHIRUDDIN (19737514) ABHAY M. GAIDHANE (19737517) NEELIMA KUKRETI (19737520) SARVESH RUSTAGI (19737523) PRAKASINI SATAPATHY (19737526) |
| dc.date.none.fl_str_mv | 2024-08-13T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ajo.2024.07.013 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Effect_of_Intravenous_Mannitol_on_Intraocular_Pressure_Changes_in_Vitrectomized_and_Non-Vitrectomized_Eyes_A_Systematic_Review_and_Meta-Analysis/27101080 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Ophthalmology and optometry Pharmacology and pharmaceutical sciences Intraocular pressure (IOP) Ophthalmic surgery Intravenous mannitol Vitrectomized eyes Non-vitrectomized eyes Meta-analysis Systematic review Pharmacology |
| dc.title.none.fl_str_mv | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">Intraocular pressure (IOP) control is paramount during ophthalmic surgeries to ensure successful outcomes and prevent complications. Intravenous mannitol has been explored for its ability to manage IOP fluctuations in both vitrectomized and non-vitrectomized eyes. This meta-analysis aimed to assess the efficacy of mannitol in controlling IOP across these patient groups.</p><h3>Design</h3><p dir="ltr">Systematic review and meta-analysis.</p><h3>Methods</h3><p dir="ltr">A literature search was conducted across PubMed, EMBASE, Scopus, and Web of Science from inception up to March 1, 2024, focusing on studies investigating mannitol's impact on IOP in vitrectomized and non-vitrectomized eyes. Randomized controlled trials, cohort studies, and case-control studies were included, while case reports and review articles were excluded. The primary outcome was the change in IOP following mannitol administration. Meta-analysis was performed using a random-effects model. R software (V 4.3) was used for statistical analysis.</p><h3>Results</h3><p dir="ltr">Our search included five studies of both vitrectomized (145 eyes) and non-vitrectomized eyes (91 eyes). The meta-analysis demonstrated significant IOP reductions following mannitol administration across multiple time points. Three studies were included at 30 min and 2 studies at all other time points in the analysis. In vitrectomized eyes, notable decreases were observed: at 30 min, the Ratio of Means (ROM) was 0.81 (95% CI: 0.53; 1.24), indicating a 19% reduction; at 60 min, the ROM of 0.833 (95% CI: 0.77; 0.89) showed a 16.7% reduction; at 90 min, the ROM of 0.757 (95% CI: 0.755; 0.758) corresponded to a 24.3% reduction; at 2 h, the ROM of 0.726 (95% CI: 0.642; 0.820) reflected a 27.4% reduction; at 3 h, the ROM of 0.692 (95% CI: 0.600; 0.797) resulted in a 30.8% reduction; and at 4 h, the ROM of 0.700 (95% CI: 0.363; 1.350) indicated a 30% reduction. No significant changes were observed on IOP with mannitol administration when comparing vitrectomized versus non- vitrectomized eyes.</p><h3>Conclusion</h3><p dir="ltr">Intravenous mannitol effectively reduces IOP in both vitrectomized and non-vitrectomized eyes, demonstrating its utility in the acute management of elevated IOP during and after ophthalmic surgeries. These findings support the integration of mannitol into perioperative care protocols. However, further research, particularly randomized controlled trials and studies with broader demographic representation, is needed to optimize mannitol's usage and fully understand its long-term safety and efficacy.</p><h2>Other Information</h2><p dir="ltr">Published in: American Journal of Ophthalmology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ajo.2024.07.013" target="_blank">https://dx.doi.org/10.1016/j.ajo.2024.07.013</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_eb7cd6c40ad251d70b931341ef3efb02 |
| identifier_str_mv | 10.1016/j.ajo.2024.07.013 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27101080 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-AnalysisHASHEM ABU SERHAN (19737499)PARUL CHAWLA GUPTA (19737502)MAHALAQUA NAZLI KHATIB (19737505)BIJAYA K. PADHI (19737508)SHILPA GAIDHANE (19737511)QUAZI SYED ZAHIRUDDIN (19737514)ABHAY M. GAIDHANE (19737517)NEELIMA KUKRETI (19737520)SARVESH RUSTAGI (19737523)PRAKASINI SATAPATHY (19737526)Biomedical and clinical sciencesClinical sciencesOphthalmology and optometryPharmacology and pharmaceutical sciencesIntraocular pressure (IOP)Ophthalmic surgeryIntravenous mannitolVitrectomized eyesNon-vitrectomized eyesMeta-analysisSystematic reviewPharmacology<h3>Purpose</h3><p dir="ltr">Intraocular pressure (IOP) control is paramount during ophthalmic surgeries to ensure successful outcomes and prevent complications. Intravenous mannitol has been explored for its ability to manage IOP fluctuations in both vitrectomized and non-vitrectomized eyes. This meta-analysis aimed to assess the efficacy of mannitol in controlling IOP across these patient groups.</p><h3>Design</h3><p dir="ltr">Systematic review and meta-analysis.</p><h3>Methods</h3><p dir="ltr">A literature search was conducted across PubMed, EMBASE, Scopus, and Web of Science from inception up to March 1, 2024, focusing on studies investigating mannitol's impact on IOP in vitrectomized and non-vitrectomized eyes. Randomized controlled trials, cohort studies, and case-control studies were included, while case reports and review articles were excluded. The primary outcome was the change in IOP following mannitol administration. Meta-analysis was performed using a random-effects model. R software (V 4.3) was used for statistical analysis.</p><h3>Results</h3><p dir="ltr">Our search included five studies of both vitrectomized (145 eyes) and non-vitrectomized eyes (91 eyes). The meta-analysis demonstrated significant IOP reductions following mannitol administration across multiple time points. Three studies were included at 30 min and 2 studies at all other time points in the analysis. In vitrectomized eyes, notable decreases were observed: at 30 min, the Ratio of Means (ROM) was 0.81 (95% CI: 0.53; 1.24), indicating a 19% reduction; at 60 min, the ROM of 0.833 (95% CI: 0.77; 0.89) showed a 16.7% reduction; at 90 min, the ROM of 0.757 (95% CI: 0.755; 0.758) corresponded to a 24.3% reduction; at 2 h, the ROM of 0.726 (95% CI: 0.642; 0.820) reflected a 27.4% reduction; at 3 h, the ROM of 0.692 (95% CI: 0.600; 0.797) resulted in a 30.8% reduction; and at 4 h, the ROM of 0.700 (95% CI: 0.363; 1.350) indicated a 30% reduction. No significant changes were observed on IOP with mannitol administration when comparing vitrectomized versus non- vitrectomized eyes.</p><h3>Conclusion</h3><p dir="ltr">Intravenous mannitol effectively reduces IOP in both vitrectomized and non-vitrectomized eyes, demonstrating its utility in the acute management of elevated IOP during and after ophthalmic surgeries. These findings support the integration of mannitol into perioperative care protocols. However, further research, particularly randomized controlled trials and studies with broader demographic representation, is needed to optimize mannitol's usage and fully understand its long-term safety and efficacy.</p><h2>Other Information</h2><p dir="ltr">Published in: American Journal of Ophthalmology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ajo.2024.07.013" target="_blank">https://dx.doi.org/10.1016/j.ajo.2024.07.013</a></p>2024-08-13T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ajo.2024.07.013https://figshare.com/articles/journal_contribution/Effect_of_Intravenous_Mannitol_on_Intraocular_Pressure_Changes_in_Vitrectomized_and_Non-Vitrectomized_Eyes_A_Systematic_Review_and_Meta-Analysis/27101080CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/271010802024-08-13T18:00:00Z |
| spellingShingle | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis HASHEM ABU SERHAN (19737499) Biomedical and clinical sciences Clinical sciences Ophthalmology and optometry Pharmacology and pharmaceutical sciences Intraocular pressure (IOP) Ophthalmic surgery Intravenous mannitol Vitrectomized eyes Non-vitrectomized eyes Meta-analysis Systematic review Pharmacology |
| status_str | publishedVersion |
| title | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| title_full | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| title_short | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| title_sort | Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis |
| topic | Biomedical and clinical sciences Clinical sciences Ophthalmology and optometry Pharmacology and pharmaceutical sciences Intraocular pressure (IOP) Ophthalmic surgery Intravenous mannitol Vitrectomized eyes Non-vitrectomized eyes Meta-analysis Systematic review Pharmacology |