Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas
<h3>Purpose</h3><p dir="ltr">We report the clinical outcomes of patients with soft tissue sarcomas (STS) arising in extremities treated with image-guided intensity modulated radiotherapy (IG-IMRT) at our institute. Local control of the tumors treated with RT was the prima...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513540535091200 |
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| author | Venkada Manickam Gurusamy (17346805) |
| author2 | Noora Al-Hammadi (17346808) Palmira Caparrotti (17346811) Saju Raveendran Divakar (17346814) Rabih Wafiq Hammoud (17346817) Ghazia Shaikh (17346820) |
| author2_role | author author author author author |
| author_facet | Venkada Manickam Gurusamy (17346805) Noora Al-Hammadi (17346808) Palmira Caparrotti (17346811) Saju Raveendran Divakar (17346814) Rabih Wafiq Hammoud (17346817) Ghazia Shaikh (17346820) |
| author_role | author |
| dc.creator.none.fl_str_mv | Venkada Manickam Gurusamy (17346805) Noora Al-Hammadi (17346808) Palmira Caparrotti (17346811) Saju Raveendran Divakar (17346814) Rabih Wafiq Hammoud (17346817) Ghazia Shaikh (17346820) |
| dc.date.none.fl_str_mv | 2022-11-02T15:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ctarc.2022.100655 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Real-world_clinical_outcomes_with_daily_image-guided_IMRT_in_extremity_soft_tissue_sarcomas/24516403 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Radiotherapy IMRT Sarcomas IGRT Soft tissue sarcomas |
| dc.title.none.fl_str_mv | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">We report the clinical outcomes of patients with soft tissue sarcomas (STS) arising in extremities treated with image-guided intensity modulated radiotherapy (IG-IMRT) at our institute. Local control of the tumors treated with RT was the primary end point of this study. Analyzing overall survival and long-term toxicities were the secondary objectives.</p><h3>Methods and materials</h3><p dir="ltr">The database of the patients with STS who received wide local excision and IG-IMRT at our institution from January 2012 to December 2020 was reviewed. Radiation was offered either preoperatively or postoperatively as part of multi-modality treatment.</p><h3>Results</h3><p dir="ltr">Thirty-three consecutive patients were identified and included for analysis. Twenty-eight patients (84.8%) received postoperative adjuvant radiotherapy. Dedicated MRI simulation studies were performed in 31 patients (93.9%) in the treatment position. RapidArc IMRT technique was used in 31 patients (93.9%). A total of 2954 images were acquired during 991 treatment sessions. Errors exceeding 1 mm in the x, y and z directions were corrected online before the treatment. With a median follow-up of 36 months, two patients (6.1%) developed local recurrence. The 3-year local control was 90.9% (95% CI, 0.76 - 0.98), and the 5-year overall survival was 71.7% (95% CI, 0.44 – 0.88). One patient (3.03%) sustained a pathological fracture during the follow-up period.</p><h3>Conclusion</h3><p dir="ltr">Our results showed that IMRT with daily imaging offered excellent local control with acceptable long-term toxicity, as well as being feasible and practical to implement in our routine clinical practice.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Treatment and Research Communications<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ctarc.2022.100655" target="_blank">https://dx.doi.org/10.1016/j.ctarc.2022.100655</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ebc31b542e9c39583462fca93c64f8d6 |
| identifier_str_mv | 10.1016/j.ctarc.2022.100655 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516403 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomasVenkada Manickam Gurusamy (17346805)Noora Al-Hammadi (17346808)Palmira Caparrotti (17346811)Saju Raveendran Divakar (17346814)Rabih Wafiq Hammoud (17346817)Ghazia Shaikh (17346820)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisRadiotherapyIMRTSarcomasIGRTSoft tissue sarcomas<h3>Purpose</h3><p dir="ltr">We report the clinical outcomes of patients with soft tissue sarcomas (STS) arising in extremities treated with image-guided intensity modulated radiotherapy (IG-IMRT) at our institute. Local control of the tumors treated with RT was the primary end point of this study. Analyzing overall survival and long-term toxicities were the secondary objectives.</p><h3>Methods and materials</h3><p dir="ltr">The database of the patients with STS who received wide local excision and IG-IMRT at our institution from January 2012 to December 2020 was reviewed. Radiation was offered either preoperatively or postoperatively as part of multi-modality treatment.</p><h3>Results</h3><p dir="ltr">Thirty-three consecutive patients were identified and included for analysis. Twenty-eight patients (84.8%) received postoperative adjuvant radiotherapy. Dedicated MRI simulation studies were performed in 31 patients (93.9%) in the treatment position. RapidArc IMRT technique was used in 31 patients (93.9%). A total of 2954 images were acquired during 991 treatment sessions. Errors exceeding 1 mm in the x, y and z directions were corrected online before the treatment. With a median follow-up of 36 months, two patients (6.1%) developed local recurrence. The 3-year local control was 90.9% (95% CI, 0.76 - 0.98), and the 5-year overall survival was 71.7% (95% CI, 0.44 – 0.88). One patient (3.03%) sustained a pathological fracture during the follow-up period.</p><h3>Conclusion</h3><p dir="ltr">Our results showed that IMRT with daily imaging offered excellent local control with acceptable long-term toxicity, as well as being feasible and practical to implement in our routine clinical practice.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Treatment and Research Communications<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ctarc.2022.100655" target="_blank">https://dx.doi.org/10.1016/j.ctarc.2022.100655</a></p>2022-11-02T15:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ctarc.2022.100655https://figshare.com/articles/journal_contribution/Real-world_clinical_outcomes_with_daily_image-guided_IMRT_in_extremity_soft_tissue_sarcomas/24516403CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245164032022-11-02T15:00:00Z |
| spellingShingle | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas Venkada Manickam Gurusamy (17346805) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Radiotherapy IMRT Sarcomas IGRT Soft tissue sarcomas |
| status_str | publishedVersion |
| title | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| title_full | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| title_fullStr | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| title_full_unstemmed | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| title_short | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| title_sort | Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Radiotherapy IMRT Sarcomas IGRT Soft tissue sarcomas |