FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib
<h3>Introduction</h3><p dir="ltr">Eosinophilia associated with FIP1L1- platelet-derived growth factor receptor A (PDGFRA) rearrangement is one of a subgroup of chronic eosinophilic leukemia, The 2008 World Health Organization classification of tumors of hematopoietic and...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513553671651328 |
|---|---|
| author | Mohammad Abu-Tineh (14829313) |
| author2 | Esra’a Aljaloudi (20381517) Aliaa Amer (14150418) Firyal Ibrahim (8984078) Wanis H. Ibrahim (14136640) Hussam Alhasson (12289540) Mohamed A. Yassin (8361183) |
| author2_role | author author author author author author |
| author_facet | Mohammad Abu-Tineh (14829313) Esra’a Aljaloudi (20381517) Aliaa Amer (14150418) Firyal Ibrahim (8984078) Wanis H. Ibrahim (14136640) Hussam Alhasson (12289540) Mohamed A. Yassin (8361183) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohammad Abu-Tineh (14829313) Esra’a Aljaloudi (20381517) Aliaa Amer (14150418) Firyal Ibrahim (8984078) Wanis H. Ibrahim (14136640) Hussam Alhasson (12289540) Mohamed A. Yassin (8361183) |
| dc.date.none.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1097/md9.0000000000000019 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/FIP1L1-_platelet-derived_growth_factor_receptor_A_-positive_chronic_eosinophilic_leukemia_showing_dramatic_response_to_imatinib/27959100 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis chronic eosinophilic leukemia eosinophilia FIP1L1- platelet-derived growth factor receptor A imatinib |
| dc.title.none.fl_str_mv | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Eosinophilia associated with FIP1L1- platelet-derived growth factor receptor A (PDGFRA) rearrangement is one of a subgroup of chronic eosinophilic leukemia, The 2008 World Health Organization classification of tumors of hematopoietic and lymphoid tissues established a new category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities in PDGFRA, platelet-derived growth factor receptor Beta (PDGFRB) or Fibroblast growth factor receptor 1. The number of reported cases is limited worldwide, with limited data on the best modality of treatment of such disease.</p><h3>Patient concerns</h3><p dir="ltr">A 48-year-old male patient with recurrent visits to the hospital presenting with multiple vague symptoms but found to have persistent marked eosinophilia.</p><h3>Diagnosis</h3><p dir="ltr">The patient was diagnosed as a case of Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of <i>PDGFRA</i></p><h3>Interventions</h3><p dir="ltr">The patient was started on Tyrosine kinase inhibitor (Imatinib) 100 mg daily.</p><h3>Outcomes</h3><p dir="ltr">The patient eosinophilia has improved markedly, and the patient's eosinophils levels dropped to normal levels within 3 weeks period.</p><h3>Conclusion</h3><p dir="ltr">This case indicates that in the era of Tyrosine Kinase inhibitors such as imatinib, the prognosis of Eosinophilia associated with <i>FIP1L1-PDGFRA</i> rearrangement has significantly improved And Prompt treatment with imatinib can lead to complete hematological response and resolution of any organ damage involved with this disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine: Case Reports and Study Protocols<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md9.0000000000000019" target="_blank">https://dx.doi.org/10.1097/md9.0000000000000019</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ecab047cc9db56a87c40eb2b77009680 |
| identifier_str_mv | 10.1097/md9.0000000000000019 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27959100 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinibMohammad Abu-Tineh (14829313)Esra’a Aljaloudi (20381517)Aliaa Amer (14150418)Firyal Ibrahim (8984078)Wanis H. Ibrahim (14136640)Hussam Alhasson (12289540)Mohamed A. Yassin (8361183)Biomedical and clinical sciencesOncology and carcinogenesischronic eosinophilic leukemiaeosinophiliaFIP1L1- platelet-derived growth factor receptor Aimatinib<h3>Introduction</h3><p dir="ltr">Eosinophilia associated with FIP1L1- platelet-derived growth factor receptor A (PDGFRA) rearrangement is one of a subgroup of chronic eosinophilic leukemia, The 2008 World Health Organization classification of tumors of hematopoietic and lymphoid tissues established a new category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities in PDGFRA, platelet-derived growth factor receptor Beta (PDGFRB) or Fibroblast growth factor receptor 1. The number of reported cases is limited worldwide, with limited data on the best modality of treatment of such disease.</p><h3>Patient concerns</h3><p dir="ltr">A 48-year-old male patient with recurrent visits to the hospital presenting with multiple vague symptoms but found to have persistent marked eosinophilia.</p><h3>Diagnosis</h3><p dir="ltr">The patient was diagnosed as a case of Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of <i>PDGFRA</i></p><h3>Interventions</h3><p dir="ltr">The patient was started on Tyrosine kinase inhibitor (Imatinib) 100 mg daily.</p><h3>Outcomes</h3><p dir="ltr">The patient eosinophilia has improved markedly, and the patient's eosinophils levels dropped to normal levels within 3 weeks period.</p><h3>Conclusion</h3><p dir="ltr">This case indicates that in the era of Tyrosine Kinase inhibitors such as imatinib, the prognosis of Eosinophilia associated with <i>FIP1L1-PDGFRA</i> rearrangement has significantly improved And Prompt treatment with imatinib can lead to complete hematological response and resolution of any organ damage involved with this disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine: Case Reports and Study Protocols<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md9.0000000000000019" target="_blank">https://dx.doi.org/10.1097/md9.0000000000000019</a></p>2021-01-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1097/md9.0000000000000019https://figshare.com/articles/journal_contribution/FIP1L1-_platelet-derived_growth_factor_receptor_A_-positive_chronic_eosinophilic_leukemia_showing_dramatic_response_to_imatinib/27959100CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279591002021-01-01T00:00:00Z |
| spellingShingle | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib Mohammad Abu-Tineh (14829313) Biomedical and clinical sciences Oncology and carcinogenesis chronic eosinophilic leukemia eosinophilia FIP1L1- platelet-derived growth factor receptor A imatinib |
| status_str | publishedVersion |
| title | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| title_full | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| title_fullStr | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| title_full_unstemmed | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| title_short | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| title_sort | FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis chronic eosinophilic leukemia eosinophilia FIP1L1- platelet-derived growth factor receptor A imatinib |