<i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
<p dir="ltr">Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, complementary alternative medicine has become popular du...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2022
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| _version_ | 1864513548309233664 |
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| author | Nouralhuda Alateyah (21363215) |
| author2 | Salma M. S. Ahmad (21363218) Ishita Gupta (9203073) Arij Fouzat (21363221) Mahmoud Ibrahim Thaher (17787554) Probir Das (14151690) Ala-Eddin Al Moustafa (14153205) Allal Ouhtit (526) |
| author2_role | author author author author author author author |
| author_facet | Nouralhuda Alateyah (21363215) Salma M. S. Ahmad (21363218) Ishita Gupta (9203073) Arij Fouzat (21363221) Mahmoud Ibrahim Thaher (17787554) Probir Das (14151690) Ala-Eddin Al Moustafa (14153205) Allal Ouhtit (526) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nouralhuda Alateyah (21363215) Salma M. S. Ahmad (21363218) Ishita Gupta (9203073) Arij Fouzat (21363221) Mahmoud Ibrahim Thaher (17787554) Probir Das (14151690) Ala-Eddin Al Moustafa (14153205) Allal Ouhtit (526) |
| dc.date.none.fl_str_mv | 2022-05-11T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2022.882956 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/_i_Haematococcus_pluvialis_i_Microalgae_Extract_Inhibits_Proliferation_Invasion_and_Induces_Apoptosis_in_Breast_Cancer_Cells/29069447 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Haematococcus pluvialis microalgae, breast cancer cell proliferation apoptosis invasion |
| dc.title.none.fl_str_mv | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, complementary alternative medicine has become popular due to its safety and efficacy. <i>Haematococcus pluvialis (H. pulvialis</i>) is a green microalga living in fresh water, and its crude extract is rich of bioactives, including carotenoids, known to inhibit cancer cell growth. In the present study, we investigated the effects of a methanol crude extract called “T1” of <i>H. pulvialis</i> on cell growth and migration/invasion of the BC cell line MDA-MB-231 in comparison to the fibroblast control cells. TI significantly suppressed BC cell growth, inhibited migration and invasion and induced apoptosis. Interestingly, apoptosis was mediated by a significant loss of mutant p53 protein, and increased Bax/Bcl2 ratio. Our findings support our hypothesis that T1 exerts its anti-cancer effects by inhibiting BC invasion and inducing apoptosis mediated, at least, <i>via</i> the p53/Bax/Bcl2 pathway. Ongoing experiments aim to identify the molecular mechanisms underpinning T1-inhibited BC cell invasion using pre-designed metastasis gene-based array method.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2022.882956" target="_blank">https://dx.doi.org/10.3389/fnut.2022.882956</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ecee37f653221b1b67294383a70dd15a |
| identifier_str_mv | 10.3389/fnut.2022.882956 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29069447 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer CellsNouralhuda Alateyah (21363215)Salma M. S. Ahmad (21363218)Ishita Gupta (9203073)Arij Fouzat (21363221)Mahmoud Ibrahim Thaher (17787554)Probir Das (14151690)Ala-Eddin Al Moustafa (14153205)Allal Ouhtit (526)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesHaematococcus pluvialis microalgae,breast cancercell proliferationapoptosisinvasion<p dir="ltr">Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, complementary alternative medicine has become popular due to its safety and efficacy. <i>Haematococcus pluvialis (H. pulvialis</i>) is a green microalga living in fresh water, and its crude extract is rich of bioactives, including carotenoids, known to inhibit cancer cell growth. In the present study, we investigated the effects of a methanol crude extract called “T1” of <i>H. pulvialis</i> on cell growth and migration/invasion of the BC cell line MDA-MB-231 in comparison to the fibroblast control cells. TI significantly suppressed BC cell growth, inhibited migration and invasion and induced apoptosis. Interestingly, apoptosis was mediated by a significant loss of mutant p53 protein, and increased Bax/Bcl2 ratio. Our findings support our hypothesis that T1 exerts its anti-cancer effects by inhibiting BC invasion and inducing apoptosis mediated, at least, <i>via</i> the p53/Bax/Bcl2 pathway. Ongoing experiments aim to identify the molecular mechanisms underpinning T1-inhibited BC cell invasion using pre-designed metastasis gene-based array method.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2022.882956" target="_blank">https://dx.doi.org/10.3389/fnut.2022.882956</a></p>2022-05-11T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fnut.2022.882956https://figshare.com/articles/journal_contribution/_i_Haematococcus_pluvialis_i_Microalgae_Extract_Inhibits_Proliferation_Invasion_and_Induces_Apoptosis_in_Breast_Cancer_Cells/29069447CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290694472022-05-11T06:00:00Z |
| spellingShingle | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells Nouralhuda Alateyah (21363215) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Haematococcus pluvialis microalgae, breast cancer cell proliferation apoptosis invasion |
| status_str | publishedVersion |
| title | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| title_full | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| title_fullStr | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| title_full_unstemmed | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| title_short | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| title_sort | <i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Haematococcus pluvialis microalgae, breast cancer cell proliferation apoptosis invasion |