Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword
<p dir="ltr">In order to reconstruct injured urinary tract tissues, biodegradable scaffolds with autologous seeded cells are explored in this work. However, when cells are obtained via biopsy from individuals who have damaged organs due to infection, congenital disorders, or cancer,...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2020
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513554889048064 |
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| author | Tariq O. Abbas (11247771) |
| author2 | Tayyiba A. Ali (18131836) Shahab Uddin (154400) |
| author2_role | author author |
| author_facet | Tariq O. Abbas (11247771) Tayyiba A. Ali (18131836) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tariq O. Abbas (11247771) Tayyiba A. Ali (18131836) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2020-02-26T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cells9030538 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Urine_as_a_Main_Effector_in_Urological_Tissue_Engineering_A_Double-Edged_Sword/27827382 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biotechnology Engineering Biomedical engineering urethra tissue engineering cytotoxicity urinary reconstruction urothelial cells |
| dc.title.none.fl_str_mv | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In order to reconstruct injured urinary tract tissues, biodegradable scaffolds with autologous seeded cells are explored in this work. However, when cells are obtained via biopsy from individuals who have damaged organs due to infection, congenital disorders, or cancer, this can result in unhealthy engineered cells and donor site morbidity. Thus, neo-organ construction through an alternative cell source might be useful. Significant advancements in the isolation and utilization of urine-derived stem cells have provided opportunities for this less invasive, limitless, and versatile source of cells to be employed in urologic tissue-engineered replacement. These cells have a high potential to differentiate into urothelial and smooth muscle cells. However, urinary tract reconstruction via tissue engineering is peculiar as it takes place in a milieu of urine that imposes certain risks on the implanted cells and scaffolds as a result of the highly cytotoxic nature of urine and its detrimental effect on both growth and differentiation of these cells. Both of these projections should be tackled thoughtfully when designing a suitable approach for repairing urinary tract defects and applying the needful precautions is vital.</p><h2>Other Information</h2><p dir="ltr">Published in: Cells<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells9030538" target="_blank">https://dx.doi.org/10.3390/cells9030538</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ecf34d39fa32c4f4ccf5a90f39be32c9 |
| identifier_str_mv | 10.3390/cells9030538 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27827382 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged SwordTariq O. Abbas (11247771)Tayyiba A. Ali (18131836)Shahab Uddin (154400)Biomedical and clinical sciencesClinical sciencesMedical biotechnologyEngineeringBiomedical engineeringurethratissue engineeringcytotoxicityurinary reconstructionurothelial cells<p dir="ltr">In order to reconstruct injured urinary tract tissues, biodegradable scaffolds with autologous seeded cells are explored in this work. However, when cells are obtained via biopsy from individuals who have damaged organs due to infection, congenital disorders, or cancer, this can result in unhealthy engineered cells and donor site morbidity. Thus, neo-organ construction through an alternative cell source might be useful. Significant advancements in the isolation and utilization of urine-derived stem cells have provided opportunities for this less invasive, limitless, and versatile source of cells to be employed in urologic tissue-engineered replacement. These cells have a high potential to differentiate into urothelial and smooth muscle cells. However, urinary tract reconstruction via tissue engineering is peculiar as it takes place in a milieu of urine that imposes certain risks on the implanted cells and scaffolds as a result of the highly cytotoxic nature of urine and its detrimental effect on both growth and differentiation of these cells. Both of these projections should be tackled thoughtfully when designing a suitable approach for repairing urinary tract defects and applying the needful precautions is vital.</p><h2>Other Information</h2><p dir="ltr">Published in: Cells<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells9030538" target="_blank">https://dx.doi.org/10.3390/cells9030538</a></p>2020-02-26T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cells9030538https://figshare.com/articles/journal_contribution/Urine_as_a_Main_Effector_in_Urological_Tissue_Engineering_A_Double-Edged_Sword/27827382CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/278273822020-02-26T03:00:00Z |
| spellingShingle | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword Tariq O. Abbas (11247771) Biomedical and clinical sciences Clinical sciences Medical biotechnology Engineering Biomedical engineering urethra tissue engineering cytotoxicity urinary reconstruction urothelial cells |
| status_str | publishedVersion |
| title | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| title_full | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| title_fullStr | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| title_full_unstemmed | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| title_short | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| title_sort | Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword |
| topic | Biomedical and clinical sciences Clinical sciences Medical biotechnology Engineering Biomedical engineering urethra tissue engineering cytotoxicity urinary reconstruction urothelial cells |