Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months
<h3>Background</h3><p dir="ltr">Evidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations.</p><p><br></p><h3>Aim</h3><p dir="ltr"...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , , , |
| منشور في: |
2023
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إضافة وسم
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| _version_ | 1864513528846614528 |
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| author | Salma Younes (6424865) |
| author2 | Eleonora Nicolai (496034) Duaa W. Al-Sadeq (10976754) Nadin Younes (4863280) Nader Al-Dewik (4166527) Haissam Abou-Saleh (497840) Bushra Y. Abo-Halawa (17863883) Ali Hussein Eid (13355211) Massimo Pieri (5023022) Na Liu (102929) Hanin I. Daas (17863886) Hadi M. Yassine (4675846) Parveen B. Nizamuddin (14590613) Laith J. Abu-Raddad (9262524) Gheyath K. Nasrallah (9200525) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Salma Younes (6424865) Eleonora Nicolai (496034) Duaa W. Al-Sadeq (10976754) Nadin Younes (4863280) Nader Al-Dewik (4166527) Haissam Abou-Saleh (497840) Bushra Y. Abo-Halawa (17863883) Ali Hussein Eid (13355211) Massimo Pieri (5023022) Na Liu (102929) Hanin I. Daas (17863886) Hadi M. Yassine (4675846) Parveen B. Nizamuddin (14590613) Laith J. Abu-Raddad (9262524) Gheyath K. Nasrallah (9200525) |
| author_role | author |
| dc.creator.none.fl_str_mv | Salma Younes (6424865) Eleonora Nicolai (496034) Duaa W. Al-Sadeq (10976754) Nadin Younes (4863280) Nader Al-Dewik (4166527) Haissam Abou-Saleh (497840) Bushra Y. Abo-Halawa (17863883) Ali Hussein Eid (13355211) Massimo Pieri (5023022) Na Liu (102929) Hanin I. Daas (17863886) Hadi M. Yassine (4675846) Parveen B. Nizamuddin (14590613) Laith J. Abu-Raddad (9262524) Gheyath K. Nasrallah (9200525) |
| dc.date.none.fl_str_mv | 2023-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jiph.2023.08.009 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Follow_up_and_comparative_assessment_of_IgG_IgA_and_neutralizing_antibody_responses_to_SARS-CoV-2_between_mRNA-vaccinated_na_ve_and_unvaccinated_naturally_infected_individuals_over_10_months/25101905 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences COVID-19 MRNA vaccines Waning Neutralizing antibodies Anti-S-RBD-IgG Anti-S1-IgA |
| dc.title.none.fl_str_mv | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Evidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations.</p><p><br></p><h3>Aim</h3><p dir="ltr">In this study, we aimed to conduct a comparative assessment of antibody responses between vaccinated naïve (VN) and unvaccinated naturally infected individuals (NI) over 10 Months.</p><p><br></p><h3>Method</h3><p dir="ltr">The study comprised fully-vaccinated naïve individuals (VN; n = 596) who had no history of SARS-CoV-2 infection, and received two doses of either BNT162b2 or mRNA-1273, and naturally infected individuals who had a documented history of SARS-CoV-2 infection and no vaccination record (NI cohort; n = 218). We measured the levels of neutralizing total antibodies (NtAbs), anti-S-RBD IgG, and anti-S1 IgA titers among VN and NI up to ∼10 months from administration of the first dose, and up to ∼7 months from SARS-CoV-2 infection, respectively. To explore the relationship between the antibody responses and time, Spearman's correlation coefficient was computed. Furthermore, correlations between the levels of NtAbs/anti-S-RBD IgG and NtAbs/anti-S1 IgA were examined through pairwise correlation analysis.</p><p><br></p><h3>Results</h3><p dir="ltr">Up to six months, VN individuals had a significantly higher NtAb and anti-S-RBD IgG antibody responses compared to NI individuals. At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. After 10 months, the most significant decline among VN individuals was observed for S-RBD-IgG (30.0-fold; P < 0.001), followed by NtAb (15.7-fold; P < 0.001) and S-IgA (3.7-fold; P < 0.001) (most stable). Moreover, after 5 months, there was no significant difference in the IgA response between the two groups.</p><p><br></p><h3>Conclusion</h3><p dir="ltr">These findings have important implications for policymakers in the development of vaccination strategies, particularly in the consideration of booster doses to sustain long-lasting protection against COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Infection and Public Health<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jiph.2023.08.009" target="_blank">https://dx.doi.org/10.1016/j.jiph.2023.08.009</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ed8ce6f3b384c4e827d687f21b92401e |
| identifier_str_mv | 10.1016/j.jiph.2023.08.009 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25101905 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 monthsSalma Younes (6424865)Eleonora Nicolai (496034)Duaa W. Al-Sadeq (10976754)Nadin Younes (4863280)Nader Al-Dewik (4166527)Haissam Abou-Saleh (497840)Bushra Y. Abo-Halawa (17863883)Ali Hussein Eid (13355211)Massimo Pieri (5023022)Na Liu (102929)Hanin I. Daas (17863886)Hadi M. Yassine (4675846)Parveen B. Nizamuddin (14590613)Laith J. Abu-Raddad (9262524)Gheyath K. Nasrallah (9200525)Biomedical and clinical sciencesClinical sciencesCOVID-19MRNA vaccinesWaningNeutralizing antibodiesAnti-S-RBD-IgGAnti-S1-IgA<h3>Background</h3><p dir="ltr">Evidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations.</p><p><br></p><h3>Aim</h3><p dir="ltr">In this study, we aimed to conduct a comparative assessment of antibody responses between vaccinated naïve (VN) and unvaccinated naturally infected individuals (NI) over 10 Months.</p><p><br></p><h3>Method</h3><p dir="ltr">The study comprised fully-vaccinated naïve individuals (VN; n = 596) who had no history of SARS-CoV-2 infection, and received two doses of either BNT162b2 or mRNA-1273, and naturally infected individuals who had a documented history of SARS-CoV-2 infection and no vaccination record (NI cohort; n = 218). We measured the levels of neutralizing total antibodies (NtAbs), anti-S-RBD IgG, and anti-S1 IgA titers among VN and NI up to ∼10 months from administration of the first dose, and up to ∼7 months from SARS-CoV-2 infection, respectively. To explore the relationship between the antibody responses and time, Spearman's correlation coefficient was computed. Furthermore, correlations between the levels of NtAbs/anti-S-RBD IgG and NtAbs/anti-S1 IgA were examined through pairwise correlation analysis.</p><p><br></p><h3>Results</h3><p dir="ltr">Up to six months, VN individuals had a significantly higher NtAb and anti-S-RBD IgG antibody responses compared to NI individuals. At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). Among VN individuals, anti-S1 IgA levels began to decrease significantly (1.4-fold; p = 0.007) after two months, and both NtAb and S-RBD IgG levels began to decline significantly (NtAb: 2.0-fold; p = 0.042, S-RBD IgG: 2.4-fold; p = 0.035) after three months. After 10 months, the most significant decline among VN individuals was observed for S-RBD-IgG (30.0-fold; P < 0.001), followed by NtAb (15.7-fold; P < 0.001) and S-IgA (3.7-fold; P < 0.001) (most stable). Moreover, after 5 months, there was no significant difference in the IgA response between the two groups.</p><p><br></p><h3>Conclusion</h3><p dir="ltr">These findings have important implications for policymakers in the development of vaccination strategies, particularly in the consideration of booster doses to sustain long-lasting protection against COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Infection and Public Health<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jiph.2023.08.009" target="_blank">https://dx.doi.org/10.1016/j.jiph.2023.08.009</a></p>2023-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jiph.2023.08.009https://figshare.com/articles/journal_contribution/Follow_up_and_comparative_assessment_of_IgG_IgA_and_neutralizing_antibody_responses_to_SARS-CoV-2_between_mRNA-vaccinated_na_ve_and_unvaccinated_naturally_infected_individuals_over_10_months/25101905CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/251019052023-11-01T00:00:00Z |
| spellingShingle | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months Salma Younes (6424865) Biomedical and clinical sciences Clinical sciences COVID-19 MRNA vaccines Waning Neutralizing antibodies Anti-S-RBD-IgG Anti-S1-IgA |
| status_str | publishedVersion |
| title | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| title_full | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| title_fullStr | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| title_full_unstemmed | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| title_short | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| title_sort | Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months |
| topic | Biomedical and clinical sciences Clinical sciences COVID-19 MRNA vaccines Waning Neutralizing antibodies Anti-S-RBD-IgG Anti-S1-IgA |