Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
<p dir="ltr">Glutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various pathological con...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , , |
| Published: |
2025
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513533671112704 |
|---|---|
| author | Mudasir A. Kumar (21633080) |
| author2 | Sana Khurshid Baba (22502891) Inamu Rashid Khan (22502894) Mohd Shahnawaz Khan (5561069) Fohad Mabood Husain (5561072) Saheem Ahmad (285632) Mohammad Haris (564809) Mayank Singh (793077) Ammira S. Al‐Shabeeb Akil (22502897) Muzafar A. Macha (11605200) Ajaz A. Bhat (12984701) |
| author2_role | author author author author author author author author author author |
| author_facet | Mudasir A. Kumar (21633080) Sana Khurshid Baba (22502891) Inamu Rashid Khan (22502894) Mohd Shahnawaz Khan (5561069) Fohad Mabood Husain (5561072) Saheem Ahmad (285632) Mohammad Haris (564809) Mayank Singh (793077) Ammira S. Al‐Shabeeb Akil (22502897) Muzafar A. Macha (11605200) Ajaz A. Bhat (12984701) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mudasir A. Kumar (21633080) Sana Khurshid Baba (22502891) Inamu Rashid Khan (22502894) Mohd Shahnawaz Khan (5561069) Fohad Mabood Husain (5561072) Saheem Ahmad (285632) Mohammad Haris (564809) Mayank Singh (793077) Ammira S. Al‐Shabeeb Akil (22502897) Muzafar A. Macha (11605200) Ajaz A. Bhat (12984701) |
| dc.date.none.fl_str_mv | 2025-06-25T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/mco2.70120 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Glutamine_Metabolism_Molecular_Regulation_Biological_Functions_and_Diseases/30455018 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis cancer circular RNAs glutaminolysis glutamine metabolism long noncoding RNAs therapeutic targeting |
| dc.title.none.fl_str_mv | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Glutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various pathological conditions, including cancers and metabolic and neurological diseases. Emerging evidence shows that long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and oncogenic alterations in glutamine transporters and enzymes enhance glutamine's role as an alternative energy source, supporting cell survival and proliferation under nutrient and oxygen deprivation conditions. To combat the pathogenic effects of altered glutamine metabolism, researchers are developing targeted inhibitors of key enzymes and transporters involved in glutaminolysis. By interfering with the mechanisms that support the growth of cancer cells, these inhibitors may be able to stop the growth of tumors and treat metabolic and neurological conditions. This review provides a comprehensive overview of existing inhibitors and ongoing clinical trials targeting glutamine metabolism, focusing on its potential as a cancer therapeutic strategy. Additionally, the role of lncRNAs and circRNAs in regulating glutamine metabolism is explored, revealing novel avenues for therapeutic intervention in cancer and other diseases.</p><h2>Other Information</h2><p dir="ltr">Published in: MedComm<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/mco2.70120" target="_blank">https://dx.doi.org/10.1002/mco2.70120</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f044b0a476a5f770bcd45f08b0b4d04f |
| identifier_str_mv | 10.1002/mco2.70120 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30455018 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Glutamine Metabolism: Molecular Regulation, Biological Functions, and DiseasesMudasir A. Kumar (21633080)Sana Khurshid Baba (22502891)Inamu Rashid Khan (22502894)Mohd Shahnawaz Khan (5561069)Fohad Mabood Husain (5561072)Saheem Ahmad (285632)Mohammad Haris (564809)Mayank Singh (793077)Ammira S. Al‐Shabeeb Akil (22502897)Muzafar A. Macha (11605200)Ajaz A. Bhat (12984701)Biomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesiscancercircular RNAsglutaminolysisglutamine metabolismlong noncoding RNAstherapeutic targeting<p dir="ltr">Glutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various pathological conditions, including cancers and metabolic and neurological diseases. Emerging evidence shows that long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and oncogenic alterations in glutamine transporters and enzymes enhance glutamine's role as an alternative energy source, supporting cell survival and proliferation under nutrient and oxygen deprivation conditions. To combat the pathogenic effects of altered glutamine metabolism, researchers are developing targeted inhibitors of key enzymes and transporters involved in glutaminolysis. By interfering with the mechanisms that support the growth of cancer cells, these inhibitors may be able to stop the growth of tumors and treat metabolic and neurological conditions. This review provides a comprehensive overview of existing inhibitors and ongoing clinical trials targeting glutamine metabolism, focusing on its potential as a cancer therapeutic strategy. Additionally, the role of lncRNAs and circRNAs in regulating glutamine metabolism is explored, revealing novel avenues for therapeutic intervention in cancer and other diseases.</p><h2>Other Information</h2><p dir="ltr">Published in: MedComm<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/mco2.70120" target="_blank">https://dx.doi.org/10.1002/mco2.70120</a></p>2025-06-25T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/mco2.70120https://figshare.com/articles/journal_contribution/Glutamine_Metabolism_Molecular_Regulation_Biological_Functions_and_Diseases/30455018CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304550182025-06-25T09:00:00Z |
| spellingShingle | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases Mudasir A. Kumar (21633080) Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis cancer circular RNAs glutaminolysis glutamine metabolism long noncoding RNAs therapeutic targeting |
| status_str | publishedVersion |
| title | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| title_full | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| title_fullStr | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| title_full_unstemmed | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| title_short | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| title_sort | Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis cancer circular RNAs glutaminolysis glutamine metabolism long noncoding RNAs therapeutic targeting |