Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population
<p dir="ltr">Natural human knockouts of genes associated with desirable outcomes, such as <i>PCSK9</i> with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homoz...
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2023
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