Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

<p dir="ltr">Natural human knockouts of genes associated with desirable outcomes, such as <i>PCSK9</i> with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homoz...

Full description

Saved in:
Bibliographic Details
Main Author: Aziz Belkadi (779313) (author)
Other Authors: Gaurav Thareja (459188) (author), Fatemeh Abbaszadeh (13841344) (author), Ramin Badii (491543) (author), Eric Fauman (3900379) (author), Omar M.E. Albagha (18508167) (author), Karsten Suhre (67967) (author)
Published: 2023
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Pharmacology and pharmaceutical sciences
human gene knockouts
metabolomicsproteomics
whole-genome sequencing
consanguineous population
drug target validation
drug target identification
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items