Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size
<h3>Background</h3><p dir="ltr">Functional hypogonadism is a condition in which some, but not all, older men have low testosterone levels. Rather than chronological age per se, the causality of hypogonadism includes obesity and impaired general health (e.g., metabolic syn...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2023
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| الموضوعات: | |
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| _version_ | 1864513530586202112 |
|---|---|
| author | Aksam Yassin (14779204) |
| author2 | Mustafa Alwani (17787566) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) Raidh Talib (14779198) Joanne Nettleship (29762) Daniel Kelly (7412216) Bassam Albaba (17787569) |
| author2_role | author author author author author author author |
| author_facet | Aksam Yassin (14779204) Mustafa Alwani (17787566) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) Raidh Talib (14779198) Joanne Nettleship (29762) Daniel Kelly (7412216) Bassam Albaba (17787569) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aksam Yassin (14779204) Mustafa Alwani (17787566) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) Raidh Talib (14779198) Joanne Nettleship (29762) Daniel Kelly (7412216) Bassam Albaba (17787569) |
| dc.date.none.fl_str_mv | 2023-05-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11255-023-03602-4 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Voiding_function_improves_under_long-term_testosterone_treatment_TTh_in_hypogonadal_men_independent_of_prostate_size/24997709 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Hypogonadism Testosterone LUTS Benign prostate hyperplasia Prostate cancer |
| dc.title.none.fl_str_mv | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Functional hypogonadism is a condition in which some, but not all, older men have low testosterone levels. Rather than chronological age per se, the causality of hypogonadism includes obesity and impaired general health (e.g., metabolic syndrome). An association between testosterone deficiency and lower urinary tract symptoms (LUTS) has been reported, yet due to prostate safety concerns, men with severe LUTS (IPSS score > 19) have invariably been excluded from entering testosterone trials. Irrespective, exogenous testosterone has not been demonstrated to cause de novo or worsen mild to moderate LUTS.</p><h3>Objective</h3><p dir="ltr">This study investigated whether long-term testosterone therapy (TTh) could have a protective effect on improving the symptoms of LUTS in hypogonadal men. However, the exact mechanism by which testosterone exerts is beneficial effect remains uncertain.</p><h3>Patients and methods</h3><p dir="ltr">In this study 321 hypogonadal patients with an average age of 58.9 ± 9.52 years received testosterone undecanoate in 12-week intervals for 12 years. One hundred and forty-seven of these males had the testosterone treatment interrupted for a mean of 16.9 months before it was resumed. Total testosterone, International Prostate Symptom Scale (IPSS), post-voiding residual bladder volume and aging male symptoms (AMS) were measured over the study period.</p><h3>Results</h3><p dir="ltr">Prior to TTh interruption, it was observed that testosterone stimulation improved the men’s IPSS, AMS and post-voiding residual bladder volume, while their prostate volume significantly increased. During the TTh interruption, there was a significant worsening in these parameters, although the increase in prostate volume continued. When TTh was resumed, these effects were reversed, implying that hypogonadism may require lifelong treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: International Urology and Nephrology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11255-023-03602-4" target="_blank">https://dx.doi.org/10.1007/s11255-023-03602-4</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f2b1e01d60f565f40c538baa4aa0af24 |
| identifier_str_mv | 10.1007/s11255-023-03602-4 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24997709 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate sizeAksam Yassin (14779204)Mustafa Alwani (17787566)Raed M. Al-Zoubi (2037490)Omar M. Aboumarzouk (14779240)Raidh Talib (14779198)Joanne Nettleship (29762)Daniel Kelly (7412216)Bassam Albaba (17787569)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisHypogonadismTestosteroneLUTSBenign prostate hyperplasiaProstate cancer<h3>Background</h3><p dir="ltr">Functional hypogonadism is a condition in which some, but not all, older men have low testosterone levels. Rather than chronological age per se, the causality of hypogonadism includes obesity and impaired general health (e.g., metabolic syndrome). An association between testosterone deficiency and lower urinary tract symptoms (LUTS) has been reported, yet due to prostate safety concerns, men with severe LUTS (IPSS score > 19) have invariably been excluded from entering testosterone trials. Irrespective, exogenous testosterone has not been demonstrated to cause de novo or worsen mild to moderate LUTS.</p><h3>Objective</h3><p dir="ltr">This study investigated whether long-term testosterone therapy (TTh) could have a protective effect on improving the symptoms of LUTS in hypogonadal men. However, the exact mechanism by which testosterone exerts is beneficial effect remains uncertain.</p><h3>Patients and methods</h3><p dir="ltr">In this study 321 hypogonadal patients with an average age of 58.9 ± 9.52 years received testosterone undecanoate in 12-week intervals for 12 years. One hundred and forty-seven of these males had the testosterone treatment interrupted for a mean of 16.9 months before it was resumed. Total testosterone, International Prostate Symptom Scale (IPSS), post-voiding residual bladder volume and aging male symptoms (AMS) were measured over the study period.</p><h3>Results</h3><p dir="ltr">Prior to TTh interruption, it was observed that testosterone stimulation improved the men’s IPSS, AMS and post-voiding residual bladder volume, while their prostate volume significantly increased. During the TTh interruption, there was a significant worsening in these parameters, although the increase in prostate volume continued. When TTh was resumed, these effects were reversed, implying that hypogonadism may require lifelong treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: International Urology and Nephrology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11255-023-03602-4" target="_blank">https://dx.doi.org/10.1007/s11255-023-03602-4</a></p>2023-05-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11255-023-03602-4https://figshare.com/articles/journal_contribution/Voiding_function_improves_under_long-term_testosterone_treatment_TTh_in_hypogonadal_men_independent_of_prostate_size/24997709CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249977092023-05-01T00:00:00Z |
| spellingShingle | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size Aksam Yassin (14779204) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Hypogonadism Testosterone LUTS Benign prostate hyperplasia Prostate cancer |
| status_str | publishedVersion |
| title | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| title_full | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| title_fullStr | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| title_full_unstemmed | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| title_short | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| title_sort | Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Hypogonadism Testosterone LUTS Benign prostate hyperplasia Prostate cancer |