Modulation of SLFN11 induces changes in DNA Damage response in breast cancer

Modulation of SLFN11 induces changes in DNA Damage response in breast cancer

<h3>Background</h3><p dir="ltr">Lack of Schlafen family member 11 (SLFN11) expression has been recently identified as a dominant genomic determinant of response to DNA damaging agents in numerous cancer types. Thus, several strategies aimed at increasing SLFN11 are explor...

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Main Author: Christophe Michel Raynaud (17449906) (author)
Other Authors: Eiman I. Ahmed (6595514) (author), Ayesha Jabeen (5438063) (author), Apryl Sanchez (17449909) (author), Shimaa Sherif (12862990) (author), Tatiana C. Carneiro-Lobo (17449912) (author), Amany Awad (17449915) (author), Dina Awartani (17449918) (author), Adviti Naik (673163) (author), Remy Thomas (702843) (author), Julie Decock (44558) (author), Gabriele Zoppoli (201733) (author), Davide Bedongnetti (17449921) (author), Wouter R. L. Hendrickx (17449924) (author)
Published: 2023
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
SLFN11
Breast cancer
Chemosensitivity
UNISAM
KRAB
Cisplatin
Epirubicin
Olaparib
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