Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study
<h3>Background</h3><p dir="ltr">Natalizumab dramatically reduces relapses and MRI inflammatory activity (new lesions and enhancing lesions) in multiple sclerosis (MS). Chemical exchange saturation transfer (CEST) MRI can explore brain tissue in vivo with high resolution a...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2023
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513550771290112 |
|---|---|
| author | Radu Tanasescu (439168) |
| author2 | Olivier Mougin (17541336) I-Jun Chou (671330) Ali Al-Radaideh (17930141) Oltita P. Jerca (17541342) Su-Yin Lim (17109253) Penny Gowland (615649) Cris S. Constantinescu (10649157) |
| author2_role | author author author author author author author |
| author_facet | Radu Tanasescu (439168) Olivier Mougin (17541336) I-Jun Chou (671330) Ali Al-Radaideh (17930141) Oltita P. Jerca (17541342) Su-Yin Lim (17109253) Penny Gowland (615649) Cris S. Constantinescu (10649157) |
| author_role | author |
| dc.creator.none.fl_str_mv | Radu Tanasescu (439168) Olivier Mougin (17541336) I-Jun Chou (671330) Ali Al-Radaideh (17930141) Oltita P. Jerca (17541342) Su-Yin Lim (17109253) Penny Gowland (615649) Cris S. Constantinescu (10649157) |
| dc.date.none.fl_str_mv | 2023-10-17T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/brainsci13101464 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Natalizumab_Treatment_for_Relapsing_Multiple_Sclerosis_Stabilises_Normal-Appearing_White_Matter_Microstructure_A_One-Year_Prospective_Ultra-High-Field_Quantitative_Imaging_Study/24717165 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Engineering Biomedical engineering multiple sclerosis ultra-high-field MRI natalizumab normal-appearing white matter |
| dc.title.none.fl_str_mv | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Natalizumab dramatically reduces relapses and MRI inflammatory activity (new lesions and enhancing lesions) in multiple sclerosis (MS). Chemical exchange saturation transfer (CEST) MRI can explore brain tissue in vivo with high resolution and sensitivity. We investigated if natalizumab can prevent microstructural tissue damage progression measured with MRI at ultra-high field (7 Tesla) over the first year of treatment. </p><h3>Methods </h3><p dir="ltr">In this one-year prospective longitudinal study, patients with active relapsing–remitting MS were assessed clinically and scanned at ultra-high-field MRI at the time of their first natalizumab infusion, at 6 and 12 months, with quantitative imaging aimed to detect microstructural changes in the normal-appearing white matter (NAWM), including sequences sensitive to magnetisation transfer (MT) effects from amide proton transfer (MTRAPT) and the nuclear Overhauser effect (MTRNOE). </p><h3>Results</h3><p dir="ltr">12 patients were recruited, and 10 patients completed the study. The difference in the T1 relaxation times at month 6 and month 12 of natalizumab treatment was not significant, suggesting the lack of accumulation of tissue damage, while improvements were seen in MTR (MTRAPT and MTRNOE measures) at month 12, suggesting a tissue repair effect. This paralleled the expected lack of clinical and radiological worsening of conventional MRI measures of disease activity (new lesions or gadolinium-enhancing lesions). </p><h3>Conclusion</h3><p dir="ltr">Natalizumab prevents microstructural brain damage and has effects suggesting an improved white matter microstructure measured at ultra-high field during the first year of treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/brainsci13101464" target="_blank">https://dx.doi.org/10.3390/brainsci13101464</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f583ba4a71d429dc030522a0a9ad61ee |
| identifier_str_mv | 10.3390/brainsci13101464 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24717165 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging StudyRadu Tanasescu (439168)Olivier Mougin (17541336)I-Jun Chou (671330)Ali Al-Radaideh (17930141)Oltita P. Jerca (17541342)Su-Yin Lim (17109253)Penny Gowland (615649)Cris S. Constantinescu (10649157)Biomedical and clinical sciencesClinical sciencesNeurosciencesEngineeringBiomedical engineeringmultiple sclerosisultra-high-field MRInatalizumabnormal-appearing white matter<h3>Background</h3><p dir="ltr">Natalizumab dramatically reduces relapses and MRI inflammatory activity (new lesions and enhancing lesions) in multiple sclerosis (MS). Chemical exchange saturation transfer (CEST) MRI can explore brain tissue in vivo with high resolution and sensitivity. We investigated if natalizumab can prevent microstructural tissue damage progression measured with MRI at ultra-high field (7 Tesla) over the first year of treatment. </p><h3>Methods </h3><p dir="ltr">In this one-year prospective longitudinal study, patients with active relapsing–remitting MS were assessed clinically and scanned at ultra-high-field MRI at the time of their first natalizumab infusion, at 6 and 12 months, with quantitative imaging aimed to detect microstructural changes in the normal-appearing white matter (NAWM), including sequences sensitive to magnetisation transfer (MT) effects from amide proton transfer (MTRAPT) and the nuclear Overhauser effect (MTRNOE). </p><h3>Results</h3><p dir="ltr">12 patients were recruited, and 10 patients completed the study. The difference in the T1 relaxation times at month 6 and month 12 of natalizumab treatment was not significant, suggesting the lack of accumulation of tissue damage, while improvements were seen in MTR (MTRAPT and MTRNOE measures) at month 12, suggesting a tissue repair effect. This paralleled the expected lack of clinical and radiological worsening of conventional MRI measures of disease activity (new lesions or gadolinium-enhancing lesions). </p><h3>Conclusion</h3><p dir="ltr">Natalizumab prevents microstructural brain damage and has effects suggesting an improved white matter microstructure measured at ultra-high field during the first year of treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/brainsci13101464" target="_blank">https://dx.doi.org/10.3390/brainsci13101464</a></p>2023-10-17T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/brainsci13101464https://figshare.com/articles/journal_contribution/Natalizumab_Treatment_for_Relapsing_Multiple_Sclerosis_Stabilises_Normal-Appearing_White_Matter_Microstructure_A_One-Year_Prospective_Ultra-High-Field_Quantitative_Imaging_Study/24717165CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247171652023-10-17T06:00:00Z |
| spellingShingle | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study Radu Tanasescu (439168) Biomedical and clinical sciences Clinical sciences Neurosciences Engineering Biomedical engineering multiple sclerosis ultra-high-field MRI natalizumab normal-appearing white matter |
| status_str | publishedVersion |
| title | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| title_full | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| title_fullStr | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| title_full_unstemmed | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| title_short | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| title_sort | Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Engineering Biomedical engineering multiple sclerosis ultra-high-field MRI natalizumab normal-appearing white matter |