Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
<div><p>Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyz...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513518720516096 |
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| author | Fayaz Ahmad Mir (11828354) |
| author2 | Ehsan Ullah (2698921) Raghvendra Mall (581171) Ahmad Iskandarani (3520067) Tareq A. Samra (9440765) Farhan Cyprian (12829466) Aijaz Parray (290256) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Faisal Farooq (13134579) Abdul-Badi Abou-Samra (3411167) |
| author2_role | author author author author author author author author author author |
| author_facet | Fayaz Ahmad Mir (11828354) Ehsan Ullah (2698921) Raghvendra Mall (581171) Ahmad Iskandarani (3520067) Tareq A. Samra (9440765) Farhan Cyprian (12829466) Aijaz Parray (290256) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Faisal Farooq (13134579) Abdul-Badi Abou-Samra (3411167) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fayaz Ahmad Mir (11828354) Ehsan Ullah (2698921) Raghvendra Mall (581171) Ahmad Iskandarani (3520067) Tareq A. Samra (9440765) Farhan Cyprian (12829466) Aijaz Parray (290256) Meis Alkasem (9440768) Ibrahem Abdalhakam (13134576) Faisal Farooq (13134579) Abdul-Badi Abou-Samra (3411167) |
| dc.date.none.fl_str_mv | 2022-08-29T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms23179821 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Dysregulated_Metabolic_Pathways_in_Subjects_with_Obesity_and_Metabolic_Syndrome/25662654 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Chemical sciences Inorganic chemistry Organic chemistry Physical chemistry Theoretical and computational chemistry metabolomics obesity metabolic syndrome inflammation sphingomyelins |
| dc.title.none.fl_str_mv | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms23179821" target="_blank">https://dx.doi.org/10.3390/ijms23179821</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f5c0d490f3e5d77da41540a776a05273 |
| identifier_str_mv | 10.3390/ijms23179821 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25662654 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic SyndromeFayaz Ahmad Mir (11828354)Ehsan Ullah (2698921)Raghvendra Mall (581171)Ahmad Iskandarani (3520067)Tareq A. Samra (9440765)Farhan Cyprian (12829466)Aijaz Parray (290256)Meis Alkasem (9440768)Ibrahem Abdalhakam (13134576)Faisal Farooq (13134579)Abdul-Badi Abou-Samra (3411167)Chemical sciencesInorganic chemistryOrganic chemistryPhysical chemistryTheoretical and computational chemistrymetabolomicsobesitymetabolic syndromeinflammationsphingomyelins<div><p>Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms23179821" target="_blank">https://dx.doi.org/10.3390/ijms23179821</a></p>2022-08-29T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms23179821https://figshare.com/articles/journal_contribution/Dysregulated_Metabolic_Pathways_in_Subjects_with_Obesity_and_Metabolic_Syndrome/25662654CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256626542022-08-29T03:00:00Z |
| spellingShingle | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome Fayaz Ahmad Mir (11828354) Chemical sciences Inorganic chemistry Organic chemistry Physical chemistry Theoretical and computational chemistry metabolomics obesity metabolic syndrome inflammation sphingomyelins |
| status_str | publishedVersion |
| title | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| title_full | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| title_fullStr | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| title_full_unstemmed | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| title_short | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| title_sort | Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome |
| topic | Chemical sciences Inorganic chemistry Organic chemistry Physical chemistry Theoretical and computational chemistry metabolomics obesity metabolic syndrome inflammation sphingomyelins |