Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target
<p dir="ltr"><u>Fatty acid synthase</u> (FASN) is a critical <u>enzyme</u> essential for the production of fats in the body. The abnormal expression of FASN is associated with different types of <u>malignancies</u>, including <u>ovarian cance...
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2024
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| _version_ | 1864513513474490368 |
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| author | Nuha Ahmad (22302754) |
| author2 | Safwan Moton (17347027) Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Tariq Masoodi (8117702) Sarfraz Ahmad (11841817) Shahab Uddin (154400) |
| author2_role | author author author author author author |
| author_facet | Nuha Ahmad (22302754) Safwan Moton (17347027) Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Tariq Masoodi (8117702) Sarfraz Ahmad (11841817) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nuha Ahmad (22302754) Safwan Moton (17347027) Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Tariq Masoodi (8117702) Sarfraz Ahmad (11841817) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2024-07-16T12:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.prp.2024.155465 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Fatty_acid_synthase_A_key_driver_of_ovarian_cancer_metastasis_and_a_promising_therapeutic_target/30197065 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Reproductive medicine Ovarian cancer FASN Lipogenesis Metabolic oncogene Signaling pathways Therapeutic target |
| dc.title.none.fl_str_mv | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr"><u>Fatty acid synthase</u> (FASN) is a critical <u>enzyme</u> essential for the production of fats in the body. The abnormal expression of FASN is associated with different types of <u>malignancies</u>, including <u>ovarian cancer</u>. FASN plays a crucial role in cell growth and survival as a metabolic <u>oncogene</u>, although the specific processes that cause its dysregulation are still unknown. FASN interacts with <u>signaling pathways</u> linked to the progression of cancer. Pharmacologically inhibiting or inactivating the FASN gene has shown potential in causing the death of<u> cancer cells</u>, offering a possible treatment approach. This review examines the function of FASN in ovarian cancer, namely its level of expression, influence on the advancement of the disease, and its potential as a target for therapeutic interventions.</p><h2>Other Information</h2><p dir="ltr">Published in: Pathology - Research and Practice<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.prp.2024.155465" target="_blank">https://dx.doi.org/10.1016/j.prp.2024.155465</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f5cd61b7ac25c6410f0da3150330b778 |
| identifier_str_mv | 10.1016/j.prp.2024.155465 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30197065 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic targetNuha Ahmad (22302754)Safwan Moton (17347027)Shilpa Kuttikrishnan (3520079)Kirti S. Prabhu (4246144)Tariq Masoodi (8117702)Sarfraz Ahmad (11841817)Shahab Uddin (154400)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesReproductive medicineOvarian cancerFASNLipogenesisMetabolic oncogeneSignaling pathwaysTherapeutic target<p dir="ltr"><u>Fatty acid synthase</u> (FASN) is a critical <u>enzyme</u> essential for the production of fats in the body. The abnormal expression of FASN is associated with different types of <u>malignancies</u>, including <u>ovarian cancer</u>. FASN plays a crucial role in cell growth and survival as a metabolic <u>oncogene</u>, although the specific processes that cause its dysregulation are still unknown. FASN interacts with <u>signaling pathways</u> linked to the progression of cancer. Pharmacologically inhibiting or inactivating the FASN gene has shown potential in causing the death of<u> cancer cells</u>, offering a possible treatment approach. This review examines the function of FASN in ovarian cancer, namely its level of expression, influence on the advancement of the disease, and its potential as a target for therapeutic interventions.</p><h2>Other Information</h2><p dir="ltr">Published in: Pathology - Research and Practice<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.prp.2024.155465" target="_blank">https://dx.doi.org/10.1016/j.prp.2024.155465</a></p>2024-07-16T12:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.prp.2024.155465https://figshare.com/articles/journal_contribution/Fatty_acid_synthase_A_key_driver_of_ovarian_cancer_metastasis_and_a_promising_therapeutic_target/30197065CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301970652024-07-16T12:00:00Z |
| spellingShingle | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target Nuha Ahmad (22302754) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Reproductive medicine Ovarian cancer FASN Lipogenesis Metabolic oncogene Signaling pathways Therapeutic target |
| status_str | publishedVersion |
| title | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| title_full | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| title_fullStr | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| title_full_unstemmed | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| title_short | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| title_sort | Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Reproductive medicine Ovarian cancer FASN Lipogenesis Metabolic oncogene Signaling pathways Therapeutic target |