Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity
<div><p>Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies. Response rates are however suboptimal, and despite considerable efforts, predicting response to immune checkpoint inhibitors a...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513515347247104 |
|---|---|
| author | Allan Relecom (14153295) |
| author2 | Maysaloun Merhi (4246147) Varghese Inchakalody (15263530) Shahab Uddin (154400) Darawan Rinchai (742366) Davide Bedognetti (2632474) Said Dermime (79420) |
| author2_role | author author author author author author |
| author_facet | Allan Relecom (14153295) Maysaloun Merhi (4246147) Varghese Inchakalody (15263530) Shahab Uddin (154400) Darawan Rinchai (742366) Davide Bedognetti (2632474) Said Dermime (79420) |
| author_role | author |
| dc.creator.none.fl_str_mv | Allan Relecom (14153295) Maysaloun Merhi (4246147) Varghese Inchakalody (15263530) Shahab Uddin (154400) Darawan Rinchai (742366) Davide Bedognetti (2632474) Said Dermime (79420) |
| dc.date.none.fl_str_mv | 2021-02-18T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13046-021-01872-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Emerging_dynamics_pathways_of_response_and_resistance_to_PD-1_and_CTLA-4_blockade_tackling_uncertainty_by_confronting_complexity/25867672 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Dynamics biomarkers Immune checkpoint inhibitors PD-1 CTLA-4 Tregs MDSCs |
| dc.title.none.fl_str_mv | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies. Response rates are however suboptimal, and despite considerable efforts, predicting response to immune checkpoint inhibitors ahead of their administration in a given patient remains elusive. The study of the dynamics of the immune system and of the tumor under immune checkpoint blockade brought insight into the mechanisms of action of these therapeutic agents. Equally relevant are the mechanisms of adaptive resistance to immune checkpoint inhibitors that have been uncovered through this approach. In this review, we discuss the dynamics of the immune system and of the tumor under immune checkpoint blockade emanating from recent studies on animal models and humans. We will focus on mechanisms of action and of resistance conveying information predictive of therapeutic response.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Experimental & Clinical Cancer Research<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13046-021-01872-3" target="_blank">https://dx.doi.org/10.1186/s13046-021-01872-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f7897e980b40419a308d8f53af51e151 |
| identifier_str_mv | 10.1186/s13046-021-01872-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25867672 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexityAllan Relecom (14153295)Maysaloun Merhi (4246147)Varghese Inchakalody (15263530)Shahab Uddin (154400)Darawan Rinchai (742366)Davide Bedognetti (2632474)Said Dermime (79420)Biomedical and clinical sciencesImmunologyOncology and carcinogenesisDynamics biomarkersImmune checkpoint inhibitorsPD-1CTLA-4TregsMDSCs<div><p>Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies. Response rates are however suboptimal, and despite considerable efforts, predicting response to immune checkpoint inhibitors ahead of their administration in a given patient remains elusive. The study of the dynamics of the immune system and of the tumor under immune checkpoint blockade brought insight into the mechanisms of action of these therapeutic agents. Equally relevant are the mechanisms of adaptive resistance to immune checkpoint inhibitors that have been uncovered through this approach. In this review, we discuss the dynamics of the immune system and of the tumor under immune checkpoint blockade emanating from recent studies on animal models and humans. We will focus on mechanisms of action and of resistance conveying information predictive of therapeutic response.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Experimental & Clinical Cancer Research<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13046-021-01872-3" target="_blank">https://dx.doi.org/10.1186/s13046-021-01872-3</a></p>2021-02-18T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13046-021-01872-3https://figshare.com/articles/journal_contribution/Emerging_dynamics_pathways_of_response_and_resistance_to_PD-1_and_CTLA-4_blockade_tackling_uncertainty_by_confronting_complexity/25867672CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258676722021-02-18T03:00:00Z |
| spellingShingle | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity Allan Relecom (14153295) Biomedical and clinical sciences Immunology Oncology and carcinogenesis Dynamics biomarkers Immune checkpoint inhibitors PD-1 CTLA-4 Tregs MDSCs |
| status_str | publishedVersion |
| title | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| title_full | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| title_fullStr | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| title_full_unstemmed | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| title_short | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| title_sort | Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Dynamics biomarkers Immune checkpoint inhibitors PD-1 CTLA-4 Tregs MDSCs |