Flavonoids against the SARS-CoV-2 induced inflammatory storm
<p>The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, import...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , , , , , , |
| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513511927840768 |
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| author | Alena Liskova (11008851) |
| author2 | Marek Samec (14727823) Lenka Koklesova (18102994) Samson M. Samuel (4278691) Kevin Zhai (18877843) Raghad Khalid Al-Ishaq (18891598) Mariam Abotaleb (18808261) Vladimir Nosal (18891601) Karol Kajo (5926877) Milad Ashrafizadeh (12342797) Ali Zarrabi (6061781) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Peter Sabaka (16830192) Ioana Mozos (18891604) David Ullrich (18891607) Robert Prosecky (18891610) Giampiero La Rocca (338682) Martin Caprnda (18891613) Dietrich Büsselberg (11008857) Luis Rodrigo (363404) Peter Kruzliak (3565505) Peter Kubatka (11008854) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Alena Liskova (11008851) Marek Samec (14727823) Lenka Koklesova (18102994) Samson M. Samuel (4278691) Kevin Zhai (18877843) Raghad Khalid Al-Ishaq (18891598) Mariam Abotaleb (18808261) Vladimir Nosal (18891601) Karol Kajo (5926877) Milad Ashrafizadeh (12342797) Ali Zarrabi (6061781) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Peter Sabaka (16830192) Ioana Mozos (18891604) David Ullrich (18891607) Robert Prosecky (18891610) Giampiero La Rocca (338682) Martin Caprnda (18891613) Dietrich Büsselberg (11008857) Luis Rodrigo (363404) Peter Kruzliak (3565505) Peter Kubatka (11008854) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alena Liskova (11008851) Marek Samec (14727823) Lenka Koklesova (18102994) Samson M. Samuel (4278691) Kevin Zhai (18877843) Raghad Khalid Al-Ishaq (18891598) Mariam Abotaleb (18808261) Vladimir Nosal (18891601) Karol Kajo (5926877) Milad Ashrafizadeh (12342797) Ali Zarrabi (6061781) Aranka Brockmueller (11064675) Mehdi Shakibaei (325455) Peter Sabaka (16830192) Ioana Mozos (18891604) David Ullrich (18891607) Robert Prosecky (18891610) Giampiero La Rocca (338682) Martin Caprnda (18891613) Dietrich Büsselberg (11008857) Luis Rodrigo (363404) Peter Kruzliak (3565505) Peter Kubatka (11008854) |
| dc.date.none.fl_str_mv | 2021-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.biopha.2021.111430 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Flavonoids_against_the_SARS-CoV-2_induced_inflammatory_storm/26114323 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Medical microbiology Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry SARS-CoV-2 COVID-19 Inflammation Cytokine storm Phytochemicals Flavonoids Immunomodulation Anti-inflammatory effects |
| dc.title.none.fl_str_mv | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out by the regulation of inflammatory mediators, the inhibition of endothelial activation, NLRP3 inflammasome, toll-like receptors (TLRs) or bromodomain containing protein 4 (BRD4), and the activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2), might be beneficial in regulating the cytokine storm during SARS-CoV-2 infection. Moreover, the ability of flavonoids to inhibit dipeptidyl peptidase 4 (DPP4), neutralize 3-chymotrypsin-like protease (3CLpro) or to affect gut microbiota to maintain immune response, and the dual action of angiotensin-converting enzyme 2 (ACE-2) may potentially also be applied to the exaggerated inflammatory responses induced by SARS-CoV-2. Based on the previously proven effects of flavonoids in other diseases or on the basis of newly published studies associated with COVID-19 (bioinformatics, molecular docking), it is reasonable to assume positive effects of flavonoids on inflammatory changes associated with COVID-19. This review highlights the current state of knowledge of the utility of flavonoids in the management of COVID-19 and also points to the multiple biological effects of flavonoids on signaling pathways associated with the inflammation processes that are deregulated in the pathology induced by SARS-CoV-2. The identification of agents, including naturally occurring substances such as flavonoids, represents great approach potentially utilizable in the management of COVID-19. Although not clinically investigated yet, the applicability of flavonoids against COVID-19 could be a promising strategy due to a broad spectrum of their biological activities.</p><h2>Other Information</h2> <p> Published in: Biomedicine & Pharmacotherapy<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2021.111430" target="_blank">https://dx.doi.org/10.1016/j.biopha.2021.111430</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f85144a3fb3a991ba89569a1978e7078 |
| identifier_str_mv | 10.1016/j.biopha.2021.111430 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114323 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Flavonoids against the SARS-CoV-2 induced inflammatory stormAlena Liskova (11008851)Marek Samec (14727823)Lenka Koklesova (18102994)Samson M. Samuel (4278691)Kevin Zhai (18877843)Raghad Khalid Al-Ishaq (18891598)Mariam Abotaleb (18808261)Vladimir Nosal (18891601)Karol Kajo (5926877)Milad Ashrafizadeh (12342797)Ali Zarrabi (6061781)Aranka Brockmueller (11064675)Mehdi Shakibaei (325455)Peter Sabaka (16830192)Ioana Mozos (18891604)David Ullrich (18891607)Robert Prosecky (18891610)Giampiero La Rocca (338682)Martin Caprnda (18891613)Dietrich Büsselberg (11008857)Luis Rodrigo (363404)Peter Kruzliak (3565505)Peter Kubatka (11008854)Biomedical and clinical sciencesImmunologyMedical microbiologyPharmacology and pharmaceutical sciencesChemical sciencesMedicinal and biomolecular chemistrySARS-CoV-2COVID-19InflammationCytokine stormPhytochemicalsFlavonoidsImmunomodulationAnti-inflammatory effects<p>The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out by the regulation of inflammatory mediators, the inhibition of endothelial activation, NLRP3 inflammasome, toll-like receptors (TLRs) or bromodomain containing protein 4 (BRD4), and the activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2), might be beneficial in regulating the cytokine storm during SARS-CoV-2 infection. Moreover, the ability of flavonoids to inhibit dipeptidyl peptidase 4 (DPP4), neutralize 3-chymotrypsin-like protease (3CLpro) or to affect gut microbiota to maintain immune response, and the dual action of angiotensin-converting enzyme 2 (ACE-2) may potentially also be applied to the exaggerated inflammatory responses induced by SARS-CoV-2. Based on the previously proven effects of flavonoids in other diseases or on the basis of newly published studies associated with COVID-19 (bioinformatics, molecular docking), it is reasonable to assume positive effects of flavonoids on inflammatory changes associated with COVID-19. This review highlights the current state of knowledge of the utility of flavonoids in the management of COVID-19 and also points to the multiple biological effects of flavonoids on signaling pathways associated with the inflammation processes that are deregulated in the pathology induced by SARS-CoV-2. The identification of agents, including naturally occurring substances such as flavonoids, represents great approach potentially utilizable in the management of COVID-19. Although not clinically investigated yet, the applicability of flavonoids against COVID-19 could be a promising strategy due to a broad spectrum of their biological activities.</p><h2>Other Information</h2> <p> Published in: Biomedicine & Pharmacotherapy<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2021.111430" target="_blank">https://dx.doi.org/10.1016/j.biopha.2021.111430</a></p>2021-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.biopha.2021.111430https://figshare.com/articles/journal_contribution/Flavonoids_against_the_SARS-CoV-2_induced_inflammatory_storm/26114323CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261143232021-06-01T00:00:00Z |
| spellingShingle | Flavonoids against the SARS-CoV-2 induced inflammatory storm Alena Liskova (11008851) Biomedical and clinical sciences Immunology Medical microbiology Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry SARS-CoV-2 COVID-19 Inflammation Cytokine storm Phytochemicals Flavonoids Immunomodulation Anti-inflammatory effects |
| status_str | publishedVersion |
| title | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| title_full | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| title_fullStr | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| title_full_unstemmed | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| title_short | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| title_sort | Flavonoids against the SARS-CoV-2 induced inflammatory storm |
| topic | Biomedical and clinical sciences Immunology Medical microbiology Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry SARS-CoV-2 COVID-19 Inflammation Cytokine storm Phytochemicals Flavonoids Immunomodulation Anti-inflammatory effects |