Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
<h3>Background</h3><p dir="ltr">Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigene...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2023
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| الموضوعات: | |
| الوسوم: |
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| _version_ | 1864513507170451456 |
|---|---|
| author | Yosra Bejaoui (8552574) |
| author2 | Fathima Humaira Amanullah (17472986) Mohamad Saad (214545) Sara Taleb (11264352) Martina Bradic (4923361) Andre Megarbane (3485465) Ali Ait Hssain (9538617) Charbel Abi Khalil (781797) Nady El Hajj (686554) |
| author2_role | author author author author author author author author |
| author_facet | Yosra Bejaoui (8552574) Fathima Humaira Amanullah (17472986) Mohamad Saad (214545) Sara Taleb (11264352) Martina Bradic (4923361) Andre Megarbane (3485465) Ali Ait Hssain (9538617) Charbel Abi Khalil (781797) Nady El Hajj (686554) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yosra Bejaoui (8552574) Fathima Humaira Amanullah (17472986) Mohamad Saad (214545) Sara Taleb (11264352) Martina Bradic (4923361) Andre Megarbane (3485465) Ali Ait Hssain (9538617) Charbel Abi Khalil (781797) Nady El Hajj (686554) |
| dc.date.none.fl_str_mv | 2023-11-28T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13148-023-01597-4 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epigenetic_age_acceleration_in_surviving_versus_deceased_COVID-19_patients_with_acute_respiratory_distress_syndrome_following_hospitalization/26827789 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Health sciences Public health COVID-19 Epigenetic clocks Epigenetic age acceleration SARS-CoV-2 |
| dc.title.none.fl_str_mv | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic clocks have been shown to be valuable tools for measuring biological age in various tissues and samples. As such, these epigenetic clocks can determine accelerated biological aging and time-to-mortality across various tissues. Previous reports have shown accelerated biological aging and telomere attrition acceleration following SARS-CoV-2 infection. However, the effect of accelerated epigenetic aging on outcome (death/recovery) in COVID-19 patients with acute respiratory distress syndrome (ARDS) has not been well investigated.</p><h3>Results</h3><p dir="ltr">In this study, we measured DNA methylation age and telomere attrition in 87 severe COVID-19 cases with ARDS under mechanical ventilation. Furthermore, we compared dynamic changes in epigenetic aging across multiple time points until recovery or death. Epigenetic age was measured using the Horvath, Hannum, DNAm skin and blood, GrimAge, and PhenoAge clocks, whereas telomere length was calculated using the surrogate marker DNAmTL. Our analysis revealed significant accelerated epigenetic aging but no telomere attrition acceleration in severe COVID-19 cases. In addition, we observed epigenetic age deceleration at inclusion versus end of follow-up in recovered but not in deceased COVID-19 cases using certain clocks. When comparing dynamic changes in epigenetic age acceleration (EAA), we detected higher EAA using both the Horvath and PhenoAge clocks in deceased versus recovered patients. The DNAmTL measurements revealed telomere attrition acceleration in deceased COVID-19 patients between inclusion and end of follow-up and a significant change in dynamic telomere attrition acceleration when comparing patients who recovered versus those who died.</p><h3>Conclusions</h3><p dir="ltr">EAA and telomere attrition acceleration were associated with treatment outcomes in hospitalized COVID-19 patients with ARDS. A better understanding of the long-term effects of EAA in COVID-19 patients and how they might contribute to long COVID symptoms in recovered individuals is urgently needed.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Epigenetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13148-023-01597-4" target="_blank">https://dx.doi.org/10.1186/s13148-023-01597-4</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_f8d1c0e59adda0e9afc083c15195fd48 |
| identifier_str_mv | 10.1186/s13148-023-01597-4 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26827789 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalizationYosra Bejaoui (8552574)Fathima Humaira Amanullah (17472986)Mohamad Saad (214545)Sara Taleb (11264352)Martina Bradic (4923361)Andre Megarbane (3485465)Ali Ait Hssain (9538617)Charbel Abi Khalil (781797)Nady El Hajj (686554)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesHealth sciencesPublic healthCOVID-19Epigenetic clocksEpigenetic age accelerationSARS-CoV-2<h3>Background</h3><p dir="ltr">Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic clocks have been shown to be valuable tools for measuring biological age in various tissues and samples. As such, these epigenetic clocks can determine accelerated biological aging and time-to-mortality across various tissues. Previous reports have shown accelerated biological aging and telomere attrition acceleration following SARS-CoV-2 infection. However, the effect of accelerated epigenetic aging on outcome (death/recovery) in COVID-19 patients with acute respiratory distress syndrome (ARDS) has not been well investigated.</p><h3>Results</h3><p dir="ltr">In this study, we measured DNA methylation age and telomere attrition in 87 severe COVID-19 cases with ARDS under mechanical ventilation. Furthermore, we compared dynamic changes in epigenetic aging across multiple time points until recovery or death. Epigenetic age was measured using the Horvath, Hannum, DNAm skin and blood, GrimAge, and PhenoAge clocks, whereas telomere length was calculated using the surrogate marker DNAmTL. Our analysis revealed significant accelerated epigenetic aging but no telomere attrition acceleration in severe COVID-19 cases. In addition, we observed epigenetic age deceleration at inclusion versus end of follow-up in recovered but not in deceased COVID-19 cases using certain clocks. When comparing dynamic changes in epigenetic age acceleration (EAA), we detected higher EAA using both the Horvath and PhenoAge clocks in deceased versus recovered patients. The DNAmTL measurements revealed telomere attrition acceleration in deceased COVID-19 patients between inclusion and end of follow-up and a significant change in dynamic telomere attrition acceleration when comparing patients who recovered versus those who died.</p><h3>Conclusions</h3><p dir="ltr">EAA and telomere attrition acceleration were associated with treatment outcomes in hospitalized COVID-19 patients with ARDS. A better understanding of the long-term effects of EAA in COVID-19 patients and how they might contribute to long COVID symptoms in recovered individuals is urgently needed.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Epigenetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13148-023-01597-4" target="_blank">https://dx.doi.org/10.1186/s13148-023-01597-4</a></p>2023-11-28T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13148-023-01597-4https://figshare.com/articles/journal_contribution/Epigenetic_age_acceleration_in_surviving_versus_deceased_COVID-19_patients_with_acute_respiratory_distress_syndrome_following_hospitalization/26827789CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/268277892023-11-28T09:00:00Z |
| spellingShingle | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization Yosra Bejaoui (8552574) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Health sciences Public health COVID-19 Epigenetic clocks Epigenetic age acceleration SARS-CoV-2 |
| status_str | publishedVersion |
| title | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| title_full | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| title_fullStr | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| title_full_unstemmed | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| title_short | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| title_sort | Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Health sciences Public health COVID-19 Epigenetic clocks Epigenetic age acceleration SARS-CoV-2 |