Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis

Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis

<p>Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic myelogenous leukemia (CML). However, the molecular mechanism of the FOXM1/B...

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Main Author: Shilpa Kuttikrishnan (3520079) (author)
Other Authors: Tariq Masoodi (8117702) (author), Gulab Sher (12984698) (author), Ajaz A. Bhat (158004) (author), Kalyani Patil (2679424) (author), Tamam El-Elimat (694398) (author), Nicholas H. Oberlies (16036193) (author), Cedric J. Pearce (16036196) (author), Mohmmad Haris (12984704) (author), Aamir Ahmad (233201) (author), Feras Q. Alali (16036197) (author), Shahab Uddin (154400) (author)
Published: 2022
Subjects:
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Oncology and carcinogenesis
fungal metabolites
Neosetophomone B
FOXM1
BUB1B
apoptosis
leukemia
cell-cycle checkpoints
TCGA
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