Regioselective Domino C–C/C–O Arylation of 1,2,3-Triiodobenzenes and 1,3-Diketones: Synthesis and In Silico Evaluation of 7-Iodobenzo[<i>b</i>]furan as Potential ALK Inhibitors

Regioselective Domino C–C/C–O Arylation of 1,2,3-Triiodobenzenes and 1,3-Diketones: Synthesis and In Silico Evaluation of 7-Iodobenzo[<i>b</i>]furan as Potential ALK Inhibitors

<p dir="ltr">We report a simple, direct, and regioselective protocol for the synthesis of 2,3-disubstituted 7-iodobenzo[b]furans via domino double C-C/C-O arylations of 1,2,3-triiodobenzene and 1,3-dicarbonyl compounds. Remarkably, the C-arylation occurred exclusively at the terminal...

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Bibliographic Details
Main Author: Raed M. Al-Zoubi (2037490) (author)
Other Authors: Walid K. Al-Jammal (8345346) (author), Mohanad Shkoor (3768385) (author), Abdulilah D. Bani-Yaseen (17917721) (author), Abbas Khan (5141000) (author), Abdelali Agouni (181926) (author), Robert McDonald (1228902) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Pharmacology and pharmaceutical sciences
Chemical sciences
Organic chemistry
benzofuran
Iodination
Arylation
C-C coupling
C-O coupling
Substituent effect
Regioselectivity
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