Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium
<div><p>Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activ...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , , , , |
| منشور في: |
2019
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513525392605184 |
|---|---|
| author | Marek Samec (14727823) |
| author2 | Alena Liskova (11008851) Lenka Koklesova (18102994) Veronika Mestanova (18102997) Maria Franekova (18103000) Monika Kassayova (18103003) Bianka Bojkova (18103006) Sona Uramova (18103009) Pavol Zubor (18103012) Katarina Janikova (18103015) Jan Danko (18103018) Samson Samuel (6828956) Dietrich Büsselberg (11008857) Peter Kubatka (11008854) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Marek Samec (14727823) Alena Liskova (11008851) Lenka Koklesova (18102994) Veronika Mestanova (18102997) Maria Franekova (18103000) Monika Kassayova (18103003) Bianka Bojkova (18103006) Sona Uramova (18103009) Pavol Zubor (18103012) Katarina Janikova (18103015) Jan Danko (18103018) Samson Samuel (6828956) Dietrich Büsselberg (11008857) Peter Kubatka (11008854) |
| author_role | author |
| dc.creator.none.fl_str_mv | Marek Samec (14727823) Alena Liskova (11008851) Lenka Koklesova (18102994) Veronika Mestanova (18102997) Maria Franekova (18103000) Monika Kassayova (18103003) Bianka Bojkova (18103006) Sona Uramova (18103009) Pavol Zubor (18103012) Katarina Janikova (18103015) Jan Danko (18103018) Samson Samuel (6828956) Dietrich Büsselberg (11008857) Peter Kubatka (11008854) |
| dc.date.none.fl_str_mv | 2019-12-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/biom9120829 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Fluctuations_of_Histone_Chemical_Modifications_in_Breast_Prostate_and_Colorectal_Cancer_An_Implication_of_Phytochemicals_as_Defenders_of_Chromatin_Equilibrium/25340701 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology breast cancer prostate cancer colorectal cancer epigenetics posttranslational chemical modifications histone phytochemicals |
| dc.title.none.fl_str_mv | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Biomolecules<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/biom9120829" target="_blank">https://dx.doi.org/10.3390/biom9120829</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_faf9a68566454966f96b97e3687b8a7f |
| identifier_str_mv | 10.3390/biom9120829 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25340701 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin EquilibriumMarek Samec (14727823)Alena Liskova (11008851)Lenka Koklesova (18102994)Veronika Mestanova (18102997)Maria Franekova (18103000)Monika Kassayova (18103003)Bianka Bojkova (18103006)Sona Uramova (18103009)Pavol Zubor (18103012)Katarina Janikova (18103015)Jan Danko (18103018)Samson Samuel (6828956)Dietrich Büsselberg (11008857)Peter Kubatka (11008854)Biological sciencesBiochemistry and cell biologybreast cancerprostate cancercolorectal cancerepigeneticsposttranslational chemical modificationshistonephytochemicals<div><p>Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Biomolecules<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/biom9120829" target="_blank">https://dx.doi.org/10.3390/biom9120829</a></p>2019-12-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/biom9120829https://figshare.com/articles/journal_contribution/Fluctuations_of_Histone_Chemical_Modifications_in_Breast_Prostate_and_Colorectal_Cancer_An_Implication_of_Phytochemicals_as_Defenders_of_Chromatin_Equilibrium/25340701CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253407012019-12-05T03:00:00Z |
| spellingShingle | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium Marek Samec (14727823) Biological sciences Biochemistry and cell biology breast cancer prostate cancer colorectal cancer epigenetics posttranslational chemical modifications histone phytochemicals |
| status_str | publishedVersion |
| title | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| title_full | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| title_fullStr | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| title_full_unstemmed | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| title_short | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| title_sort | Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium |
| topic | Biological sciences Biochemistry and cell biology breast cancer prostate cancer colorectal cancer epigenetics posttranslational chemical modifications histone phytochemicals |