Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke
<h3>Objective</h3><p dir="ltr">To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).</p><h3&...
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2019
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| _version_ | 1864513552186867712 |
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| author | Hoda Gad (6470522) |
| author2 | Adnan Khan (696190) Naveed Akhtar (4919398) Saadat Kamran (4919416) Ahmed El-Sotouhy (6470525) Soha R. Dargham (3613250) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Ashfaq Shuaib (4919407) Leopold J. Streletz (6470528) Rayaz A. Malik (7372649) |
| author2_role | author author author author author author author author author author |
| author_facet | Hoda Gad (6470522) Adnan Khan (696190) Naveed Akhtar (4919398) Saadat Kamran (4919416) Ahmed El-Sotouhy (6470525) Soha R. Dargham (3613250) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Ashfaq Shuaib (4919407) Leopold J. Streletz (6470528) Rayaz A. Malik (7372649) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hoda Gad (6470522) Adnan Khan (696190) Naveed Akhtar (4919398) Saadat Kamran (4919416) Ahmed El-Sotouhy (6470525) Soha R. Dargham (3613250) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Ashfaq Shuaib (4919407) Leopold J. Streletz (6470528) Rayaz A. Malik (7372649) |
| dc.date.none.fl_str_mv | 2019-03-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0213319 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Corneal_nerve_and_endothelial_cell_damage_in_patients_with_transient_ischemic_attack_and_minor_ischemic_stroke/25340839 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Corneal nerve cell damage patients transient ischemic attack minor ischemic stroke |
| dc.title.none.fl_str_mv | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objective</h3><p dir="ltr">To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).</p><h3>Methods</h3><p dir="ltr">Thirty-six patients admitted with TIA (n = 14) or minor IS (n = 22) underwent transcranial Doppler evaluation and corneal confocal microscopy and were compared with 18 healthy controls.</p><h3>Results</h3><p dir="ltr">Corneal nerve fiber density (P = 0.002), branch density (P = 0.004) and fiber length (P = 0.004) were significantly lower in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. Endothelial cell density (P = 0.003) was lower and endothelial cell area (P = 0.003) and perimeter (P = 0.006) were significantly higher in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. There were no differences in corneal nerve or endothelial cell morphology between patients with and without abnormal cerebrovascular reactivity. HbA1c was independently associated with CNFL, and endothelial cell polymegathism and pleomorphism were associated with both HbA1c and total cholesterol.</p><h3>Conclusion</h3><p dir="ltr">Corneal confocal microscopy identifies corneal nerve fiber loss and endothelial cell abnormalities in patients with TIA and minor IS and independent associations with HbA1c and cholesterol.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0213319" target="_blank">https://dx.doi.org/10.1371/journal.pone.0213319</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_fc952113edafa917176b134994787aed |
| identifier_str_mv | 10.1371/journal.pone.0213319 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25340839 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic strokeHoda Gad (6470522)Adnan Khan (696190)Naveed Akhtar (4919398)Saadat Kamran (4919416)Ahmed El-Sotouhy (6470525)Soha R. Dargham (3613250)Ioannis N. Petropoulos (8748726)Georgios Ponirakis (803076)Ashfaq Shuaib (4919407)Leopold J. Streletz (6470528)Rayaz A. Malik (7372649)Biomedical and clinical sciencesClinical sciencesCorneal nervecell damagepatientstransient ischemic attackminor ischemic stroke<h3>Objective</h3><p dir="ltr">To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).</p><h3>Methods</h3><p dir="ltr">Thirty-six patients admitted with TIA (n = 14) or minor IS (n = 22) underwent transcranial Doppler evaluation and corneal confocal microscopy and were compared with 18 healthy controls.</p><h3>Results</h3><p dir="ltr">Corneal nerve fiber density (P = 0.002), branch density (P = 0.004) and fiber length (P = 0.004) were significantly lower in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. Endothelial cell density (P = 0.003) was lower and endothelial cell area (P = 0.003) and perimeter (P = 0.006) were significantly higher in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. There were no differences in corneal nerve or endothelial cell morphology between patients with and without abnormal cerebrovascular reactivity. HbA1c was independently associated with CNFL, and endothelial cell polymegathism and pleomorphism were associated with both HbA1c and total cholesterol.</p><h3>Conclusion</h3><p dir="ltr">Corneal confocal microscopy identifies corneal nerve fiber loss and endothelial cell abnormalities in patients with TIA and minor IS and independent associations with HbA1c and cholesterol.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0213319" target="_blank">https://dx.doi.org/10.1371/journal.pone.0213319</a></p>2019-03-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0213319https://figshare.com/articles/journal_contribution/Corneal_nerve_and_endothelial_cell_damage_in_patients_with_transient_ischemic_attack_and_minor_ischemic_stroke/25340839CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253408392019-03-15T03:00:00Z |
| spellingShingle | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke Hoda Gad (6470522) Biomedical and clinical sciences Clinical sciences Corneal nerve cell damage patients transient ischemic attack minor ischemic stroke |
| status_str | publishedVersion |
| title | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| title_full | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| title_fullStr | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| title_full_unstemmed | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| title_short | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| title_sort | Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke |
| topic | Biomedical and clinical sciences Clinical sciences Corneal nerve cell damage patients transient ischemic attack minor ischemic stroke |