Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports
<p dir="ltr">The coronavirus disease 2019 (COVID-19) pandemic has been an enormous public health challenge. The pursuit for an effective therapy led to the use of the antiviral drug Remdesivir for hospitalized patients with severe COVID-19 pneumonia. We reported two cases of patients...
محفوظ في:
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513547831083008 |
|---|---|
| author | Alaaeldin Abdelmajid (12535542) |
| author2 | Wala Osman (17269054) Huda Musa (17269057) Hisham Elhiday (17269060) Waqar Munir (14506265) Muna A. Al.Maslamani (17269063) Eman Zeyad Elmekaty (17269066) |
| author2_role | author author author author author author |
| author_facet | Alaaeldin Abdelmajid (12535542) Wala Osman (17269054) Huda Musa (17269057) Hisham Elhiday (17269060) Waqar Munir (14506265) Muna A. Al.Maslamani (17269063) Eman Zeyad Elmekaty (17269066) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alaaeldin Abdelmajid (12535542) Wala Osman (17269054) Huda Musa (17269057) Hisham Elhiday (17269060) Waqar Munir (14506265) Muna A. Al.Maslamani (17269063) Eman Zeyad Elmekaty (17269066) |
| dc.date.none.fl_str_mv | 2021-08-12T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.idcr.2021.e01254 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Remdesivir_therapy_causing_bradycardia_in_COVID-19_patients_Two_case_reports/24420430 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Remdesivir COVID-19 Bradycardia Viral pneumonia SARS-CoV-2 |
| dc.title.none.fl_str_mv | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The coronavirus disease 2019 (COVID-19) pandemic has been an enormous public health challenge. The pursuit for an effective therapy led to the use of the antiviral drug Remdesivir for hospitalized patients with severe COVID-19 pneumonia. We reported two cases of patients with severe COVID-19 pneumonia and worsening oxygen requirements. Both patients developed sinus bradycardia following the initiation of Remdesivir therapy and reverted after stopping it. One of the patients developed QTc interval prolongation and required intensive care unit admission. The proposed mechanism for Remdesivir-induced bradycardia and cardiac toxicity could be due to the intrinsic electrophysiological properties and the effect on the AV node; yet, further large observational studies are warranted for better understanding and correlation of Remdesivir with cardiac adverse events. Till then, healthcare providers need to be alert of this potential adverse event and to monitor their COVID-19 patients closely while on Remdesivir therapy.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2021.e01254" target="_blank">https://dx.doi.org/10.1016/j.idcr.2021.e01254</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_fc9d38d2b4b7f9ad82be8af73a45aefc |
| identifier_str_mv | 10.1016/j.idcr.2021.e01254 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24420430 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reportsAlaaeldin Abdelmajid (12535542)Wala Osman (17269054)Huda Musa (17269057)Hisham Elhiday (17269060)Waqar Munir (14506265)Muna A. Al.Maslamani (17269063)Eman Zeyad Elmekaty (17269066)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesRemdesivirCOVID-19BradycardiaViral pneumoniaSARS-CoV-2<p dir="ltr">The coronavirus disease 2019 (COVID-19) pandemic has been an enormous public health challenge. The pursuit for an effective therapy led to the use of the antiviral drug Remdesivir for hospitalized patients with severe COVID-19 pneumonia. We reported two cases of patients with severe COVID-19 pneumonia and worsening oxygen requirements. Both patients developed sinus bradycardia following the initiation of Remdesivir therapy and reverted after stopping it. One of the patients developed QTc interval prolongation and required intensive care unit admission. The proposed mechanism for Remdesivir-induced bradycardia and cardiac toxicity could be due to the intrinsic electrophysiological properties and the effect on the AV node; yet, further large observational studies are warranted for better understanding and correlation of Remdesivir with cardiac adverse events. Till then, healthcare providers need to be alert of this potential adverse event and to monitor their COVID-19 patients closely while on Remdesivir therapy.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2021.e01254" target="_blank">https://dx.doi.org/10.1016/j.idcr.2021.e01254</a></p>2021-08-12T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.idcr.2021.e01254https://figshare.com/articles/journal_contribution/Remdesivir_therapy_causing_bradycardia_in_COVID-19_patients_Two_case_reports/24420430CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244204302021-08-12T00:00:00Z |
| spellingShingle | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports Alaaeldin Abdelmajid (12535542) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Remdesivir COVID-19 Bradycardia Viral pneumonia SARS-CoV-2 |
| status_str | publishedVersion |
| title | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| title_full | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| title_fullStr | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| title_full_unstemmed | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| title_short | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| title_sort | Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reports |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Remdesivir COVID-19 Bradycardia Viral pneumonia SARS-CoV-2 |