Including diverse and admixed populations in genetic epidemiology research
<div><p>The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (ELSI) committee of the International Geneti...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513518646067200 |
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| author | Amke Caliebe (512976) |
| author2 | Fasil Tekola‐Ayele (18421470) Burcu F. Darst (11210806) Xuexia Wang (3701098) Yeunjoo E. Song (3193155) Jiang Gui (110929) Ronnie A. Sebro (12854868) David J. Balding (18421473) Mohamad Saad (214545) Marie‐Pierre Dubé (18421476) IGES ELSI Committee (18421479) |
| author2_role | author author author author author author author author author author |
| author_facet | Amke Caliebe (512976) Fasil Tekola‐Ayele (18421470) Burcu F. Darst (11210806) Xuexia Wang (3701098) Yeunjoo E. Song (3193155) Jiang Gui (110929) Ronnie A. Sebro (12854868) David J. Balding (18421473) Mohamad Saad (214545) Marie‐Pierre Dubé (18421476) IGES ELSI Committee (18421479) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amke Caliebe (512976) Fasil Tekola‐Ayele (18421470) Burcu F. Darst (11210806) Xuexia Wang (3701098) Yeunjoo E. Song (3193155) Jiang Gui (110929) Ronnie A. Sebro (12854868) David J. Balding (18421473) Mohamad Saad (214545) Marie‐Pierre Dubé (18421476) IGES ELSI Committee (18421479) |
| dc.date.none.fl_str_mv | 2022-07-16T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/gepi.22492 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Including_diverse_and_admixed_populations_in_genetic_epidemiology_research/25663851 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Health sciences Epidemiology admixture diversity genetic association genome‐wide association study inclusion |
| dc.title.none.fl_str_mv | Including diverse and admixed populations in genetic epidemiology research |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (ELSI) committee of the International Genetic Epidemiology Society (IGES) offer perspectives on methods and analysis tools for the conduct of inclusive genetic epidemiology research, with a focus on admixed and ancestrally diverse populations in support of reproducible research practices. We emphasize the importance of distinguishing socially defined population categorizations from genetic ancestry in the design, analysis, reporting, and interpretation of genetic epidemiology research findings. Finally, we discuss the current state of genomic resources used in genetic association studies, functional interpretation, and clinical and public health translation of genomic findings with respect to diverse populations.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Genetic Epidemiology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/gepi.22492" target="_blank">https://dx.doi.org/10.1002/gepi.22492</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_fcacfd08e01409220963bc52c8def8b7 |
| identifier_str_mv | 10.1002/gepi.22492 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25663851 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Including diverse and admixed populations in genetic epidemiology researchAmke Caliebe (512976)Fasil Tekola‐Ayele (18421470)Burcu F. Darst (11210806)Xuexia Wang (3701098)Yeunjoo E. Song (3193155)Jiang Gui (110929)Ronnie A. Sebro (12854868)David J. Balding (18421473)Mohamad Saad (214545)Marie‐Pierre Dubé (18421476)IGES ELSI Committee (18421479)Biological sciencesGeneticsHealth sciencesEpidemiologyadmixturediversitygenetic associationgenome‐wide association studyinclusion<div><p>The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (ELSI) committee of the International Genetic Epidemiology Society (IGES) offer perspectives on methods and analysis tools for the conduct of inclusive genetic epidemiology research, with a focus on admixed and ancestrally diverse populations in support of reproducible research practices. We emphasize the importance of distinguishing socially defined population categorizations from genetic ancestry in the design, analysis, reporting, and interpretation of genetic epidemiology research findings. Finally, we discuss the current state of genomic resources used in genetic association studies, functional interpretation, and clinical and public health translation of genomic findings with respect to diverse populations.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Genetic Epidemiology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/gepi.22492" target="_blank">https://dx.doi.org/10.1002/gepi.22492</a></p>2022-07-16T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/gepi.22492https://figshare.com/articles/journal_contribution/Including_diverse_and_admixed_populations_in_genetic_epidemiology_research/25663851CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256638512022-07-16T03:00:00Z |
| spellingShingle | Including diverse and admixed populations in genetic epidemiology research Amke Caliebe (512976) Biological sciences Genetics Health sciences Epidemiology admixture diversity genetic association genome‐wide association study inclusion |
| status_str | publishedVersion |
| title | Including diverse and admixed populations in genetic epidemiology research |
| title_full | Including diverse and admixed populations in genetic epidemiology research |
| title_fullStr | Including diverse and admixed populations in genetic epidemiology research |
| title_full_unstemmed | Including diverse and admixed populations in genetic epidemiology research |
| title_short | Including diverse and admixed populations in genetic epidemiology research |
| title_sort | Including diverse and admixed populations in genetic epidemiology research |
| topic | Biological sciences Genetics Health sciences Epidemiology admixture diversity genetic association genome‐wide association study inclusion |