Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> and CD4<sup>+</sup>CD25<sup>−</sup>Foxp3<sup>+</sup> T cells

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> and CD4<sup>+</sup>CD25<sup>−</sup>Foxp3<sup>+</sup> T cells

<h3>Background</h3><p dir="ltr">The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune...

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Bibliographic Details
Main Author: Magdalena J. Polanczyk (14153283) (author)
Other Authors: Edwin Walker (4705993) (author), Daniel Haley (14153286) (author), Bella S. Guerrouahen (14153289) (author), Emmanuel T. Akporiaye (8335038) (author)
Published: 2019
Subjects:
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Immunology
Medical biochemistry and metabolomics
Oncology and carcinogenesis
TGF-β
SM16
Mice
Treg subsets
Anti-tumor response
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