Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis
<h3>Background</h3><p dir="ltr">Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims to ascertain PCT's accura...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2024
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إضافة وسم
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| _version_ | 1864513545560915968 |
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| author | Hany A. Zaki (17337673) |
| author2 | Soumaya Bensliman (21633077) Khalid Bashir (9300293) Haris Iftikhar (15954223) Mohamed H. Fayed (18974849) Waleed Salem (19794156) Amr Elmoheen (16404882) Yavuz Yigit (17788490) |
| author2_role | author author author author author author author |
| author_facet | Hany A. Zaki (17337673) Soumaya Bensliman (21633077) Khalid Bashir (9300293) Haris Iftikhar (15954223) Mohamed H. Fayed (18974849) Waleed Salem (19794156) Amr Elmoheen (16404882) Yavuz Yigit (17788490) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hany A. Zaki (17337673) Soumaya Bensliman (21633077) Khalid Bashir (9300293) Haris Iftikhar (15954223) Mohamed H. Fayed (18974849) Waleed Salem (19794156) Amr Elmoheen (16404882) Yavuz Yigit (17788490) |
| dc.date.none.fl_str_mv | 2024-01-22T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13643-023-02432-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Accuracy_of_procalcitonin_for_diagnosing_sepsis_in_adult_patients_admitted_to_the_emergency_department_a_systematic_review_and_meta-analysis/29445608 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Sepsis Systemic Inflammatory Response Syndrome (SIRS) Procalcitonin (PCT) Biomarkers Emergency department Diagnostic accuracy |
| dc.title.none.fl_str_mv | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims to ascertain PCT's accuracy as a sepsis biomarker among adult emergency department admissions.</p><h3>Method</h3><p dir="ltr">The PRISMA guidelines were followed to search for relevant articles in five electronic databases between April 14th and August 4th, 2023: PubMed, Cochrane Library, ProQuest, EMBASEs, and ScienceDirect. Studies had to be published in English to avoid directly translating scientific terms. Besides, the inclusion criteria were based on the diagnosis of sepsis in adult patients admitted to an emergency department. QUADAS-2 tool provided by the Review Manager version 5.4.1 was utilized to assess the risk of bias in included studies. STATA (v. 16) software was used to perform the meta-analysis.</p><h3>Results</h3><p dir="ltr">Ten of 2457 studies were included. We sampled 2980 adult sepsis patients for the under-investigated role of PCT in ED sepsis diagnosis. PCT emerged as the primary early diagnostic biomarker with high levels (29.3 ± 85.3 ng/mL) in sepsis patients. Heterogeneity in outcomes, possibly due to bias in cohort and observational studies, was observed.</p><h3>Conclusion</h3><p dir="ltr">PCT tests offer moderate accuracy in diagnosing sepsis and stand out for rapidly and precisely distinguishing between viral and bacterial inflammations.</p><h2>Other Information</h2><p dir="ltr">Published in: Systematic Reviews<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13643-023-02432-w" target="_blank">https://dx.doi.org/10.1186/s13643-023-02432-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_fe201dd0d8edb75336b63710984537b6 |
| identifier_str_mv | 10.1186/s13643-023-02432-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29445608 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysisHany A. Zaki (17337673)Soumaya Bensliman (21633077)Khalid Bashir (9300293)Haris Iftikhar (15954223)Mohamed H. Fayed (18974849)Waleed Salem (19794156)Amr Elmoheen (16404882)Yavuz Yigit (17788490)Biomedical and clinical sciencesClinical sciencesSepsis SystemicInflammatory Response Syndrome (SIRS)Procalcitonin (PCT)BiomarkersEmergency departmentDiagnostic accuracy<h3>Background</h3><p dir="ltr">Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims to ascertain PCT's accuracy as a sepsis biomarker among adult emergency department admissions.</p><h3>Method</h3><p dir="ltr">The PRISMA guidelines were followed to search for relevant articles in five electronic databases between April 14th and August 4th, 2023: PubMed, Cochrane Library, ProQuest, EMBASEs, and ScienceDirect. Studies had to be published in English to avoid directly translating scientific terms. Besides, the inclusion criteria were based on the diagnosis of sepsis in adult patients admitted to an emergency department. QUADAS-2 tool provided by the Review Manager version 5.4.1 was utilized to assess the risk of bias in included studies. STATA (v. 16) software was used to perform the meta-analysis.</p><h3>Results</h3><p dir="ltr">Ten of 2457 studies were included. We sampled 2980 adult sepsis patients for the under-investigated role of PCT in ED sepsis diagnosis. PCT emerged as the primary early diagnostic biomarker with high levels (29.3 ± 85.3 ng/mL) in sepsis patients. Heterogeneity in outcomes, possibly due to bias in cohort and observational studies, was observed.</p><h3>Conclusion</h3><p dir="ltr">PCT tests offer moderate accuracy in diagnosing sepsis and stand out for rapidly and precisely distinguishing between viral and bacterial inflammations.</p><h2>Other Information</h2><p dir="ltr">Published in: Systematic Reviews<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13643-023-02432-w" target="_blank">https://dx.doi.org/10.1186/s13643-023-02432-w</a></p>2024-01-22T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13643-023-02432-whttps://figshare.com/articles/journal_contribution/Accuracy_of_procalcitonin_for_diagnosing_sepsis_in_adult_patients_admitted_to_the_emergency_department_a_systematic_review_and_meta-analysis/29445608CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294456082024-01-22T09:00:00Z |
| spellingShingle | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis Hany A. Zaki (17337673) Biomedical and clinical sciences Clinical sciences Sepsis Systemic Inflammatory Response Syndrome (SIRS) Procalcitonin (PCT) Biomarkers Emergency department Diagnostic accuracy |
| status_str | publishedVersion |
| title | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| title_full | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| title_fullStr | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| title_full_unstemmed | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| title_short | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| title_sort | Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis |
| topic | Biomedical and clinical sciences Clinical sciences Sepsis Systemic Inflammatory Response Syndrome (SIRS) Procalcitonin (PCT) Biomarkers Emergency department Diagnostic accuracy |