Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

<h2>Background</h2><p dir="ltr">Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phloretin remain elusive.</p>&l...

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Bibliographic Details
Main Author: Sarita Saraswati (7509626) (author)
Other Authors: Abdulqader Alhaider (7509629) (author), Abdelgalil Mohamed Abdelgadir (14153268) (author), Pooja Tanwer (7509635) (author), Hesham M. Korashy (1474849) (author)
Published: 2019
Subjects:
Biological sciences
Biochemistry and cell biology
Chemical sciences
Medicinal and biomolecular chemistry
Phloretin
Sorafenib
STAT3
SHP-1
hepatocellular carcinoma
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