Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine
<h3>Background</h3><p dir="ltr">Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease. Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of IBD nor will it improve its clinical management. Therefore, it is vital to dissec...
محفوظ في:
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| مؤلفون آخرون: | , |
| منشور في: |
2019
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| _version_ | 1864513511317569536 |
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| author | Manoj Kumar (205700) |
| author2 | Mathieu Garand (4861942) Souhaila Al Khodor (89983) |
| author2_role | author author |
| author_facet | Manoj Kumar (205700) Mathieu Garand (4861942) Souhaila Al Khodor (89983) |
| author_role | author |
| dc.creator.none.fl_str_mv | Manoj Kumar (205700) Mathieu Garand (4861942) Souhaila Al Khodor (89983) |
| dc.date.none.fl_str_mv | 2019-12-13T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12967-019-02174-1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Integrating_omics_for_a_better_understanding_of_Inflammatory_Bowel_Disease_a_step_towards_personalized_medicine/26015821 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Paediatrics Crohn’s disease Ulcerative colitis Multi-omics Systems biology |
| dc.title.none.fl_str_mv | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease. Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of IBD nor will it improve its clinical management. Therefore, it is vital to dissect the interactions between the different players in IBD pathogenesis in order to understand the biology of the disease and enhance its clinical outcomes.</p><h3>Aims</h3><p dir="ltr">To provide an overview of the available omics data used to assess the potential mechanisms through which various players are contributing to IBD pathogenesis and propose a precision medicine model to fill the current knowledge gap in IBD.</p><h3>Results</h3><p dir="ltr">Several studies have reported microbial dysbiosis, immune and metabolic dysregulation in IBD patients, however, this data is not sufficient to create signatures that can differentiate between the disease subtypes or between disease relapse and remission.</p><h3>Conclusions</h3><p dir="ltr">We summarized the current knowledge in the application of omics in IBD patients, and we showed that the current knowledge gap in IBD hinders the improvements of clinical decision for treatment as well as the prediction of disease relapse. We propose one way to fill this gap by implementing integrative analysis of various omics datasets generated from one patient at a single time point.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-019-02174-1" target="_blank">https://dx.doi.org/10.1186/s12967-019-02174-1</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_fe47fa286f0f0855c71d95ab897d717b |
| identifier_str_mv | 10.1186/s12967-019-02174-1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26015821 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicineManoj Kumar (205700)Mathieu Garand (4861942)Souhaila Al Khodor (89983)Biomedical and clinical sciencesClinical sciencesPaediatricsCrohn’s diseaseUlcerative colitisMulti-omicsSystems biology<h3>Background</h3><p dir="ltr">Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease. Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of IBD nor will it improve its clinical management. Therefore, it is vital to dissect the interactions between the different players in IBD pathogenesis in order to understand the biology of the disease and enhance its clinical outcomes.</p><h3>Aims</h3><p dir="ltr">To provide an overview of the available omics data used to assess the potential mechanisms through which various players are contributing to IBD pathogenesis and propose a precision medicine model to fill the current knowledge gap in IBD.</p><h3>Results</h3><p dir="ltr">Several studies have reported microbial dysbiosis, immune and metabolic dysregulation in IBD patients, however, this data is not sufficient to create signatures that can differentiate between the disease subtypes or between disease relapse and remission.</p><h3>Conclusions</h3><p dir="ltr">We summarized the current knowledge in the application of omics in IBD patients, and we showed that the current knowledge gap in IBD hinders the improvements of clinical decision for treatment as well as the prediction of disease relapse. We propose one way to fill this gap by implementing integrative analysis of various omics datasets generated from one patient at a single time point.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-019-02174-1" target="_blank">https://dx.doi.org/10.1186/s12967-019-02174-1</a></p>2019-12-13T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12967-019-02174-1https://figshare.com/articles/journal_contribution/Integrating_omics_for_a_better_understanding_of_Inflammatory_Bowel_Disease_a_step_towards_personalized_medicine/26015821CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260158212019-12-13T06:00:00Z |
| spellingShingle | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine Manoj Kumar (205700) Biomedical and clinical sciences Clinical sciences Paediatrics Crohn’s disease Ulcerative colitis Multi-omics Systems biology |
| status_str | publishedVersion |
| title | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| title_full | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| title_fullStr | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| title_full_unstemmed | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| title_short | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| title_sort | Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine |
| topic | Biomedical and clinical sciences Clinical sciences Paediatrics Crohn’s disease Ulcerative colitis Multi-omics Systems biology |