Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study
<h3>Background</h3><p dir="ltr">The impact of the chronological sequence of events, including cardiac arrest (CA), initial cardiopulmonary resuscitation (CPR), return of spontaneous circulation (ROSC), and extracorporeal cardiopulmonary resuscitation (ECPR) implementation...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2024
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إضافة وسم
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| _version_ | 1864513543228882944 |
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| author | Amir Vahedian-Azimi (11177056) |
| author2 | Ibrahim Fawzy Hassan (19325908) Farshid Rahimi-Bashar (11787500) Hussam Elmelliti (17347060) Mahmood Salesi (4535878) Hazim Alqahwachi (17542479) Fatima Albazoon (17563242) Anzila Akbar (21792935) Ahmed Labib Shehata (21792938) Abdulsalam Saif Ibrahim (19325905) Ali Ait Hssain (9538617) |
| author2_role | author author author author author author author author author author |
| author_facet | Amir Vahedian-Azimi (11177056) Ibrahim Fawzy Hassan (19325908) Farshid Rahimi-Bashar (11787500) Hussam Elmelliti (17347060) Mahmood Salesi (4535878) Hazim Alqahwachi (17542479) Fatima Albazoon (17563242) Anzila Akbar (21792935) Ahmed Labib Shehata (21792938) Abdulsalam Saif Ibrahim (19325905) Ali Ait Hssain (9538617) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amir Vahedian-Azimi (11177056) Ibrahim Fawzy Hassan (19325908) Farshid Rahimi-Bashar (11787500) Hussam Elmelliti (17347060) Mahmood Salesi (4535878) Hazim Alqahwachi (17542479) Fatima Albazoon (17563242) Anzila Akbar (21792935) Ahmed Labib Shehata (21792938) Abdulsalam Saif Ibrahim (19325905) Ali Ait Hssain (9538617) |
| dc.date.none.fl_str_mv | 2024-03-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12873-023-00905-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Prognostic_effects_of_cardiopulmonary_resuscitation_CPR_start_time_and_the_interval_between_CPR_to_extracorporeal_cardiopulmonary_resuscitation_ECPR_on_patient_outcomes_under_extracorporeal_membrane_oxygenation_ECMO_a_single-center_retrospe/29651057 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Cardiac arrest Cardiopulmonary resuscitation Extracorporeal circulation Extracorporeal membrane oxygenation out-of-hospital cardiac arrest In-hospital cardiac arrest Prognosis |
| dc.title.none.fl_str_mv | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">The impact of the chronological sequence of events, including cardiac arrest (CA), initial cardiopulmonary resuscitation (CPR), return of spontaneous circulation (ROSC), and extracorporeal cardiopulmonary resuscitation (ECPR) implementation, on clinical outcomes in patients with both out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA), is still not clear. The aim of this study was to investigate the prognostic effects of the time interval from collapse to start of CPR (no-flow time, NFT) and the time interval from start of CPR to implementation of ECPR (low-flow time, LFT) on patient outcomes under Extracorporeal Membrane Oxygenation (ECMO).</p><h3>Methods</h3><p dir="ltr">This single-center, retrospective observational study was conducted on 48 patients with OHCA or IHCA who underwent ECMO at Hamad General Hospital (HGH), the tertiary governmental hospital of Qatar, between February 2016 and March 2020. We investigated the impact of prognostic factors such as NFT and LFT on various clinical outcomes following cardiac arrest, including 24-hour survival, 28-day survival, CPR duration, ECMO length of stay (LOS), ICU LOS, hospital LOS, disability (assessed using the modified Rankin Scale, mRS), and neurological status (evaluated based on the Cerebral Performance Category, CPC) at 28 days after the CA.</p><h3>Results</h3><p dir="ltr">The results of the adjusted logistic regression analysis showed that a longer NFT was associated with unfavorable clinical outcomes. These outcomes included longer CPR duration (OR: 1.779, 95%CI: 1.218–2.605, <i> P</i> = 0.034) and decreased survival rates for ECMO at 24 h (OR: 0.561, 95%CI: 0.183–0.903,<i> P</i> = 0.009) and 28 days (OR: 0.498, 95%CI: 0.106–0.802, <i> P</i> = 0.011). Additionally, a longer LFT was found to be associated only with a higher probability of prolonged CPR (OR: 1.818, 95%CI: 1.332–3.312, <i> P</i>= 0.006). However, there was no statistically significant connection between either the NFT or the LFT and the improvement of disability or neurologically favorable survival after 28 days of cardiac arrest.</p><h3>Conclusions</h3><p dir="ltr">Based on our findings, it has been determined that the NFT is a more effective predictor than the LFT in assessing clinical outcomes for patients with OHCA or IHCA who underwent ECMO. This understanding of their distinct predictive abilities enables medical professionals to identify high-risk patients more accurately and customize their interventions accordingly.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Emergency Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12873-023-00905-8" target="_blank">https://dx.doi.org/10.1186/s12873-023-00905-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_fefd5f40c274ce4c12bf9caaaa3311da |
| identifier_str_mv | 10.1186/s12873-023-00905-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29651057 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational studyAmir Vahedian-Azimi (11177056)Ibrahim Fawzy Hassan (19325908)Farshid Rahimi-Bashar (11787500)Hussam Elmelliti (17347060)Mahmood Salesi (4535878)Hazim Alqahwachi (17542479)Fatima Albazoon (17563242)Anzila Akbar (21792935)Ahmed Labib Shehata (21792938)Abdulsalam Saif Ibrahim (19325905)Ali Ait Hssain (9538617)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesCardiac arrestCardiopulmonary resuscitationExtracorporeal circulationExtracorporeal membrane oxygenation out-of-hospital cardiac arrestIn-hospital cardiacarrest Prognosis<h3>Background</h3><p dir="ltr">The impact of the chronological sequence of events, including cardiac arrest (CA), initial cardiopulmonary resuscitation (CPR), return of spontaneous circulation (ROSC), and extracorporeal cardiopulmonary resuscitation (ECPR) implementation, on clinical outcomes in patients with both out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA), is still not clear. The aim of this study was to investigate the prognostic effects of the time interval from collapse to start of CPR (no-flow time, NFT) and the time interval from start of CPR to implementation of ECPR (low-flow time, LFT) on patient outcomes under Extracorporeal Membrane Oxygenation (ECMO).</p><h3>Methods</h3><p dir="ltr">This single-center, retrospective observational study was conducted on 48 patients with OHCA or IHCA who underwent ECMO at Hamad General Hospital (HGH), the tertiary governmental hospital of Qatar, between February 2016 and March 2020. We investigated the impact of prognostic factors such as NFT and LFT on various clinical outcomes following cardiac arrest, including 24-hour survival, 28-day survival, CPR duration, ECMO length of stay (LOS), ICU LOS, hospital LOS, disability (assessed using the modified Rankin Scale, mRS), and neurological status (evaluated based on the Cerebral Performance Category, CPC) at 28 days after the CA.</p><h3>Results</h3><p dir="ltr">The results of the adjusted logistic regression analysis showed that a longer NFT was associated with unfavorable clinical outcomes. These outcomes included longer CPR duration (OR: 1.779, 95%CI: 1.218–2.605, <i> P</i> = 0.034) and decreased survival rates for ECMO at 24 h (OR: 0.561, 95%CI: 0.183–0.903,<i> P</i> = 0.009) and 28 days (OR: 0.498, 95%CI: 0.106–0.802, <i> P</i> = 0.011). Additionally, a longer LFT was found to be associated only with a higher probability of prolonged CPR (OR: 1.818, 95%CI: 1.332–3.312, <i> P</i>= 0.006). However, there was no statistically significant connection between either the NFT or the LFT and the improvement of disability or neurologically favorable survival after 28 days of cardiac arrest.</p><h3>Conclusions</h3><p dir="ltr">Based on our findings, it has been determined that the NFT is a more effective predictor than the LFT in assessing clinical outcomes for patients with OHCA or IHCA who underwent ECMO. This understanding of their distinct predictive abilities enables medical professionals to identify high-risk patients more accurately and customize their interventions accordingly.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Emergency Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12873-023-00905-8" target="_blank">https://dx.doi.org/10.1186/s12873-023-00905-8</a></p>2024-03-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12873-023-00905-8https://figshare.com/articles/journal_contribution/Prognostic_effects_of_cardiopulmonary_resuscitation_CPR_start_time_and_the_interval_between_CPR_to_extracorporeal_cardiopulmonary_resuscitation_ECPR_on_patient_outcomes_under_extracorporeal_membrane_oxygenation_ECMO_a_single-center_retrospe/29651057CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/296510572024-03-05T03:00:00Z |
| spellingShingle | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study Amir Vahedian-Azimi (11177056) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Cardiac arrest Cardiopulmonary resuscitation Extracorporeal circulation Extracorporeal membrane oxygenation out-of-hospital cardiac arrest In-hospital cardiac arrest Prognosis |
| status_str | publishedVersion |
| title | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| title_full | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| title_fullStr | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| title_full_unstemmed | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| title_short | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| title_sort | Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Cardiac arrest Cardiopulmonary resuscitation Extracorporeal circulation Extracorporeal membrane oxygenation out-of-hospital cardiac arrest In-hospital cardiac arrest Prognosis |