Mechanisms underlying the effects of caloric restriction on hypertension
<p>Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional endothelium and vascular remodeling. Despite the wide use of pharm...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2022
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| _version_ | 1864513535845859328 |
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| author | Ahmad A. Al Attar (17563152) |
| author2 | Gracia I. Fahed (17563155) Malak M. Hoballah (17563158) Shona Pedersen (2792278) Ahmed F. El-Yazbi (10180589) Suzanne A. Nasser (17563161) Alessandra Bitto (4116094) Alexander N. Orekhov (9214259) Ali H. Eid (5461829) |
| author2_role | author author author author author author author author |
| author_facet | Ahmad A. Al Attar (17563152) Gracia I. Fahed (17563155) Malak M. Hoballah (17563158) Shona Pedersen (2792278) Ahmed F. El-Yazbi (10180589) Suzanne A. Nasser (17563161) Alessandra Bitto (4116094) Alexander N. Orekhov (9214259) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmad A. Al Attar (17563152) Gracia I. Fahed (17563155) Malak M. Hoballah (17563158) Shona Pedersen (2792278) Ahmed F. El-Yazbi (10180589) Suzanne A. Nasser (17563161) Alessandra Bitto (4116094) Alexander N. Orekhov (9214259) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2022-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.bcp.2022.115035 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Mechanisms_underlying_the_effects_of_caloric_restriction_on_hypertension/24745689 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Nutrition and dietetics Pharmacology and pharmaceutical sciences Caloric restrictione Hypertension Cardiovascular disease Phenotypic switch mTOR Nitric oxide |
| dc.title.none.fl_str_mv | Mechanisms underlying the effects of caloric restriction on hypertension |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional endothelium and vascular remodeling. Despite the wide use of pharmacological therapies that modulate these pathways, a large percentage of patients continue to have uncontrolled hypertension, and the use of non-pharmacological interventions is increasingly investigated. Among these, caloric restriction (CR) appears to be a promising nutritional intervention for the management of hypertension. However, the mechanisms behind this effect are not yet fully understood, although an evolving view supports a significant impact of CR on vascular structure and function, specifically at the level of vascular endothelial cells, vascular smooth muscle cells along with their extracellular matrix (ECM). Accumulating evidence suggests that CR promotes endothelium-dependent vasodilation through activating eNOS and increasing nitric oxide (NO) levels through multiple cascades involving modulation of oxidative stress, autophagy, and inflammation. Indeed, CR diminishes phenotypic shift, and suppresses proliferation and migration of VSMCs via pathways involving NO and mTOR. By regulating transforming growth factor-β and matrix metalloproteinases, CR appears to reduce ECM and collagen deposition in vascular walls. Here, we offer a detailed discussion of how these mechanisms contribute to CR’s influence on reducing blood pressure. Such mechanisms could then provide a valuable foundation on which to base new therapeutic interventions for hypertension.</p><h2>Other Information</h2> <p> Published in: Biochemical Pharmacology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bcp.2022.115035" target="_blank">https://dx.doi.org/10.1016/j.bcp.2022.115035</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ff13f083f6bce4425b9bae73aa7702a6 |
| identifier_str_mv | 10.1016/j.bcp.2022.115035 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745689 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Mechanisms underlying the effects of caloric restriction on hypertensionAhmad A. Al Attar (17563152)Gracia I. Fahed (17563155)Malak M. Hoballah (17563158)Shona Pedersen (2792278)Ahmed F. El-Yazbi (10180589)Suzanne A. Nasser (17563161)Alessandra Bitto (4116094)Alexander N. Orekhov (9214259)Ali H. Eid (5461829)Biomedical and clinical sciencesCardiovascular medicine and haematologyNutrition and dieteticsPharmacology and pharmaceutical sciencesCaloric restrictioneHypertensionCardiovascular diseasePhenotypic switchmTORNitric oxide<p>Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional endothelium and vascular remodeling. Despite the wide use of pharmacological therapies that modulate these pathways, a large percentage of patients continue to have uncontrolled hypertension, and the use of non-pharmacological interventions is increasingly investigated. Among these, caloric restriction (CR) appears to be a promising nutritional intervention for the management of hypertension. However, the mechanisms behind this effect are not yet fully understood, although an evolving view supports a significant impact of CR on vascular structure and function, specifically at the level of vascular endothelial cells, vascular smooth muscle cells along with their extracellular matrix (ECM). Accumulating evidence suggests that CR promotes endothelium-dependent vasodilation through activating eNOS and increasing nitric oxide (NO) levels through multiple cascades involving modulation of oxidative stress, autophagy, and inflammation. Indeed, CR diminishes phenotypic shift, and suppresses proliferation and migration of VSMCs via pathways involving NO and mTOR. By regulating transforming growth factor-β and matrix metalloproteinases, CR appears to reduce ECM and collagen deposition in vascular walls. Here, we offer a detailed discussion of how these mechanisms contribute to CR’s influence on reducing blood pressure. Such mechanisms could then provide a valuable foundation on which to base new therapeutic interventions for hypertension.</p><h2>Other Information</h2> <p> Published in: Biochemical Pharmacology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bcp.2022.115035" target="_blank">https://dx.doi.org/10.1016/j.bcp.2022.115035</a></p>2022-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.bcp.2022.115035https://figshare.com/articles/journal_contribution/Mechanisms_underlying_the_effects_of_caloric_restriction_on_hypertension/24745689CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247456892022-06-01T00:00:00Z |
| spellingShingle | Mechanisms underlying the effects of caloric restriction on hypertension Ahmad A. Al Attar (17563152) Biomedical and clinical sciences Cardiovascular medicine and haematology Nutrition and dietetics Pharmacology and pharmaceutical sciences Caloric restrictione Hypertension Cardiovascular disease Phenotypic switch mTOR Nitric oxide |
| status_str | publishedVersion |
| title | Mechanisms underlying the effects of caloric restriction on hypertension |
| title_full | Mechanisms underlying the effects of caloric restriction on hypertension |
| title_fullStr | Mechanisms underlying the effects of caloric restriction on hypertension |
| title_full_unstemmed | Mechanisms underlying the effects of caloric restriction on hypertension |
| title_short | Mechanisms underlying the effects of caloric restriction on hypertension |
| title_sort | Mechanisms underlying the effects of caloric restriction on hypertension |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Nutrition and dietetics Pharmacology and pharmaceutical sciences Caloric restrictione Hypertension Cardiovascular disease Phenotypic switch mTOR Nitric oxide |